The Role of Galectin-3 in The Diagnosis and Evaluation of Disease Activity in Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic autoimmune disease that primarily affects small joints, leading to joint inflammation, pain, and limited mobility. New biomarkers specific to RA could facilitate early diagnosis and treatment, while also enabling better monitoring of disease activity and treatm...
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| Format: | Article |
| Language: | Indonesian |
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Universitas Islam Negeri Raden Fatah Palembang
2023-08-01
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| Series: | Jurnal Biota |
| Subjects: | |
| Online Access: | http://jurnal.radenfatah.ac.id/index.php/biota/article/view/18343 |
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| author | Shihab Mahmood Almurshedi Raad Abdulameer Alasady Alasady Hashim Ali Alsherees Ali M. Almohana Kareem Gali Aljayashi Dhifaf Hameed Almudhaffer |
| author_facet | Shihab Mahmood Almurshedi Raad Abdulameer Alasady Alasady Hashim Ali Alsherees Ali M. Almohana Kareem Gali Aljayashi Dhifaf Hameed Almudhaffer |
| author_sort | Shihab Mahmood Almurshedi |
| collection | DOAJ |
| description | Rheumatoid Arthritis (RA) is a chronic autoimmune disease that primarily affects small joints, leading to joint inflammation, pain, and limited mobility. New biomarkers specific to RA could facilitate early diagnosis and treatment, while also enabling better monitoring of disease activity and treatment response. By ELISA, galectin-3 (gal-3) level was measured in 133 patients with inflammatory arthritis to determine the diagnostic value of gal-3 in the diagnosis of RA and evaluate the disease activity. Serum gal-3 levels were significantly higher in RA patients compared to patients with other types of inflammatory arthritis. According to CDAI, DAS-28 ESR, and DAS-28 CRP, gal-3 showed positive correlations with disease activity scores. Galectin-3 at a cut-off value of ≥ 2.4 ng/ml, revealed 89% sensitivity, 91% specificity, and an AUC of 0.893. There was a significant correlation between gal-3 and the age of RA patients, while no significant correlations were observed with gender, BMI, and smoking index. Notably, gal-3 levels correlated significantly with CRP, RF titer, and ACPA levels. Therefore, gal-3 can be considered a valuable biomarker for the diagnosis of RA and evaluating the disease activity. |
| first_indexed | 2024-03-08T11:57:49Z |
| format | Article |
| id | doaj.art-b82ae69ab51847fc9d1f2b8e62c74ac8 |
| institution | Directory Open Access Journal |
| issn | 2528-262X 2460-7746 |
| language | Indonesian |
| last_indexed | 2024-03-08T11:57:49Z |
| publishDate | 2023-08-01 |
| publisher | Universitas Islam Negeri Raden Fatah Palembang |
| record_format | Article |
| series | Jurnal Biota |
| spelling | doaj.art-b82ae69ab51847fc9d1f2b8e62c74ac82024-01-23T23:06:27ZindUniversitas Islam Negeri Raden Fatah PalembangJurnal Biota2528-262X2460-77462023-08-019211812610.19109/Biota.v9i2.1834318343The Role of Galectin-3 in The Diagnosis and Evaluation of Disease Activity in Rheumatoid ArthritisShihab Mahmood Almurshedi0Raad Abdulameer Alasady Alasady1Hashim Ali Alsherees2Ali M. Almohana3Kareem Gali Aljayashi4Dhifaf Hameed Almudhaffer5Department of Medical Microbiology/ Faculty of Medicine/ University of Kufa.Department of Medical Microbiology/ Faculty of Medicine/ University of Kufa.University of Kufa, Faculty of medicineDepartment of Medical Microbiology/ Faculty of Medicine/ University of Kufa.Department of Medical Microbiology/ Faculty of Medicine/ University of Kufa.Department of Medical Microbiology/ Faculty of Medicine/ University of Kufa.Rheumatoid Arthritis (RA) is a chronic autoimmune disease that primarily affects small joints, leading to joint inflammation, pain, and limited mobility. New biomarkers specific to RA could facilitate early diagnosis and treatment, while also enabling better monitoring of disease activity and treatment response. By ELISA, galectin-3 (gal-3) level was measured in 133 patients with inflammatory arthritis to determine the diagnostic value of gal-3 in the diagnosis of RA and evaluate the disease activity. Serum gal-3 levels were significantly higher in RA patients compared to patients with other types of inflammatory arthritis. According to CDAI, DAS-28 ESR, and DAS-28 CRP, gal-3 showed positive correlations with disease activity scores. Galectin-3 at a cut-off value of ≥ 2.4 ng/ml, revealed 89% sensitivity, 91% specificity, and an AUC of 0.893. There was a significant correlation between gal-3 and the age of RA patients, while no significant correlations were observed with gender, BMI, and smoking index. Notably, gal-3 levels correlated significantly with CRP, RF titer, and ACPA levels. Therefore, gal-3 can be considered a valuable biomarker for the diagnosis of RA and evaluating the disease activity.http://jurnal.radenfatah.ac.id/index.php/biota/article/view/18343rheumatoid arthritis, galectin-3, cdai, das-28 esr, and das-28 crp |
| spellingShingle | Shihab Mahmood Almurshedi Raad Abdulameer Alasady Alasady Hashim Ali Alsherees Ali M. Almohana Kareem Gali Aljayashi Dhifaf Hameed Almudhaffer The Role of Galectin-3 in The Diagnosis and Evaluation of Disease Activity in Rheumatoid Arthritis Jurnal Biota rheumatoid arthritis, galectin-3, cdai, das-28 esr, and das-28 crp |
| title | The Role of Galectin-3 in The Diagnosis and Evaluation of Disease Activity in Rheumatoid Arthritis |
| title_full | The Role of Galectin-3 in The Diagnosis and Evaluation of Disease Activity in Rheumatoid Arthritis |
| title_fullStr | The Role of Galectin-3 in The Diagnosis and Evaluation of Disease Activity in Rheumatoid Arthritis |
| title_full_unstemmed | The Role of Galectin-3 in The Diagnosis and Evaluation of Disease Activity in Rheumatoid Arthritis |
| title_short | The Role of Galectin-3 in The Diagnosis and Evaluation of Disease Activity in Rheumatoid Arthritis |
| title_sort | role of galectin 3 in the diagnosis and evaluation of disease activity in rheumatoid arthritis |
| topic | rheumatoid arthritis, galectin-3, cdai, das-28 esr, and das-28 crp |
| url | http://jurnal.radenfatah.ac.id/index.php/biota/article/view/18343 |
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