Association of physical activity and sitting with metabolic syndrome and hyperglycemic clamp parameters in adolescents – BRAMS pediatric study
IntroductionObesity and metabolic syndrome (MetS) have immediate and long-term consequences on adolescent health and well-being. Among the available treatments for MetS in adolescents, behavioral interventions such as increasing physical activity (PA) are preferred. This study aimed to investigate t...
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| Format: | Article |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1191935/full |
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| author | Talita Oliveira Silva Marina Maintinguer Norde Ana Carolina Vasques Mariana Porto Zambom Maria Angela Reis de Góes Monteiro Antonio Ana Maria De Bernardi Rodrigues BRAMS group Bruno Geloneze Brazilian Metabolic Syndrome Study investigators |
| author_facet | Talita Oliveira Silva Marina Maintinguer Norde Ana Carolina Vasques Mariana Porto Zambom Maria Angela Reis de Góes Monteiro Antonio Ana Maria De Bernardi Rodrigues BRAMS group Bruno Geloneze Brazilian Metabolic Syndrome Study investigators |
| author_sort | Talita Oliveira Silva |
| collection | DOAJ |
| description | IntroductionObesity and metabolic syndrome (MetS) have immediate and long-term consequences on adolescent health and well-being. Among the available treatments for MetS in adolescents, behavioral interventions such as increasing physical activity (PA) are preferred. This study aimed to investigate the association of PA and sitting time with MetS and a complete set of metabolic health parameters.MethodsData from the Pediatric Brazilian Metabolic Syndrome Study (BRAMS-P), a cross-sectional multicenter study conducted using a convenience sample of 448 Brazilian adolescents (10y–19y), were used. Sociodemographic and lifestyle information were collected using a standardized questionnaire. Daily PA and sitting time were estimated from the International PA Questionnaire. Anthropometric parameters, body composition, and blood pressure were measured by trained researchers. Blood lipids, uric acid, hepatic enzymes, creatinine, glycated hemoglobin, glucose, and insulin were measured in fasting blood samples, and the Homeostasis Model Assessment for Insulin Resistance was calculated. A subsample of 57 adolescents underwent the hyperglycemic clamp protocol.ResultsThe odds for metabolic syndrome were higher among adolescents who spent >8h sitting (OR (95%CI)=2.11 (1.02 – 4.38)), but not in those classified as active (OR (95%CI)=0.98 (0.42 – 2.26)). Adolescents who spent more time sitting had higher BMI, waist circumference, sagittal abdominal diameter, neck circumference, percentage of body fat, and worse blood lipid profile. The insulin sensitivity index was moderately and positively correlated with moderate-to-high PA in minutes per day (rho=0.29; p=0.047).ConclusionTime spent sitting was associated with worse metabolic parameters and must be restricted in favor of adolescent health. Regular PA is associated with improved insulin sensitivity and may be encouraged not only in adolescents with obesity or metabolic disorders but also to prevent adverse metabolic outcomes in normal-weight adolescents. |
| first_indexed | 2024-03-13T05:26:45Z |
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| id | doaj.art-b82ae7581fd74cbea45390eb4ad16ea8 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T05:26:45Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-b82ae7581fd74cbea45390eb4ad16ea82023-06-15T05:47:39ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-06-011410.3389/fendo.2023.11919351191935Association of physical activity and sitting with metabolic syndrome and hyperglycemic clamp parameters in adolescents – BRAMS pediatric studyTalita Oliveira Silva0Marina Maintinguer Norde1Ana Carolina Vasques2Mariana Porto Zambom3Maria Angela Reis de Góes Monteiro Antonio4Ana Maria De Bernardi Rodrigues5BRAMS groupBruno Geloneze6Brazilian Metabolic Syndrome Study investigatorsLaboratory of Diabetes and Metabolism Investigation (LIMED), School of Medical Sciences of the State University of Campinas (FCM-UNICAMP), Campinas, SP, BrazilLaboratory of Diabetes and Metabolism Investigation (LIMED), School of Medical Sciences of the State University of Campinas (FCM-UNICAMP), Campinas, SP, BrazilLaboratory of Diabetes and Metabolism Investigation (LIMED), School of Medical Sciences of the State University of Campinas (FCM-UNICAMP), Campinas, SP, BrazilDepartment of Pediatrics, FCM-UNICAMP, Campinas, SP, BrazilDepartment of Pediatrics, FCM-UNICAMP, Campinas, SP, BrazilSchool of Health and Life Sciences, Nossa Senhora do Patrocinio University, Itu, SP, BrazilLaboratory of Diabetes and Metabolism Investigation (LIMED), School of Medical Sciences of the State University of Campinas (FCM-UNICAMP), Campinas, SP, BrazilIntroductionObesity and metabolic syndrome (MetS) have immediate and long-term consequences on adolescent health and well-being. Among the available treatments for MetS in adolescents, behavioral interventions such as increasing physical activity (PA) are preferred. This study aimed to investigate the association of PA and sitting time with MetS and a complete set of metabolic health parameters.MethodsData from the Pediatric Brazilian Metabolic Syndrome Study (BRAMS-P), a cross-sectional multicenter study conducted using a convenience sample of 448 Brazilian adolescents (10y–19y), were used. Sociodemographic and lifestyle information were collected using a standardized questionnaire. Daily PA and sitting time were estimated from the International PA Questionnaire. Anthropometric parameters, body composition, and blood pressure were measured by trained researchers. Blood lipids, uric acid, hepatic enzymes, creatinine, glycated hemoglobin, glucose, and insulin were measured in fasting blood samples, and the Homeostasis Model Assessment for Insulin Resistance was calculated. A subsample of 57 adolescents underwent the hyperglycemic clamp protocol.ResultsThe odds for metabolic syndrome were higher among adolescents who spent >8h sitting (OR (95%CI)=2.11 (1.02 – 4.38)), but not in those classified as active (OR (95%CI)=0.98 (0.42 – 2.26)). Adolescents who spent more time sitting had higher BMI, waist circumference, sagittal abdominal diameter, neck circumference, percentage of body fat, and worse blood lipid profile. The insulin sensitivity index was moderately and positively correlated with moderate-to-high PA in minutes per day (rho=0.29; p=0.047).ConclusionTime spent sitting was associated with worse metabolic parameters and must be restricted in favor of adolescent health. Regular PA is associated with improved insulin sensitivity and may be encouraged not only in adolescents with obesity or metabolic disorders but also to prevent adverse metabolic outcomes in normal-weight adolescents.https://www.frontiersin.org/articles/10.3389/fendo.2023.1191935/fullphysical activityinternational physical activity questionnairesittingmetabolic syndromeadolescentshyperglycemic clamp |
| spellingShingle | Talita Oliveira Silva Marina Maintinguer Norde Ana Carolina Vasques Mariana Porto Zambom Maria Angela Reis de Góes Monteiro Antonio Ana Maria De Bernardi Rodrigues BRAMS group Bruno Geloneze Brazilian Metabolic Syndrome Study investigators Association of physical activity and sitting with metabolic syndrome and hyperglycemic clamp parameters in adolescents – BRAMS pediatric study Frontiers in Endocrinology physical activity international physical activity questionnaire sitting metabolic syndrome adolescents hyperglycemic clamp |
| title | Association of physical activity and sitting with metabolic syndrome and hyperglycemic clamp parameters in adolescents – BRAMS pediatric study |
| title_full | Association of physical activity and sitting with metabolic syndrome and hyperglycemic clamp parameters in adolescents – BRAMS pediatric study |
| title_fullStr | Association of physical activity and sitting with metabolic syndrome and hyperglycemic clamp parameters in adolescents – BRAMS pediatric study |
| title_full_unstemmed | Association of physical activity and sitting with metabolic syndrome and hyperglycemic clamp parameters in adolescents – BRAMS pediatric study |
| title_short | Association of physical activity and sitting with metabolic syndrome and hyperglycemic clamp parameters in adolescents – BRAMS pediatric study |
| title_sort | association of physical activity and sitting with metabolic syndrome and hyperglycemic clamp parameters in adolescents brams pediatric study |
| topic | physical activity international physical activity questionnaire sitting metabolic syndrome adolescents hyperglycemic clamp |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1191935/full |
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