ISL1 controls pancreatic alpha cell fate and beta cell maturation

ISL1 controls pancreatic alpha cell fate and beta cell maturation

Abstract Background Glucose homeostasis is dependent on functional pancreatic α and ß cells. The mechanisms underlying the generation and maturation of these endocrine cells remain unclear. Results We unravel the molecular mode of action of ISL1 in controlling α cell fate and the formation of functi...

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Bibliographic Details
Main Authors: Romana Bohuslavova, Valeria Fabriciova, Laura Lebrón-Mora, Jessica Malfatti, Ondrej Smolik, Lukas Valihrach, Sarka Benesova, Daniel Zucha, Zuzana Berkova, Frantisek Saudek, Sylvia M Evans, Gabriela Pavlinkova
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell & Bioscience
Subjects:
Pancreatic endocrine cells
Epigenetic histone modification
Transcriptome
Pancreas development
Online Access:https://doi.org/10.1186/s13578-023-01003-9

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