Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection
Mast cells (MCs) are strategically located at the host-environment interface and their non-allergic roles in the immune-surveillance of pathogens have recently gained more attention. However, MC-caused detrimental regulation of immune inflammations can promote viral invasion. Currently, the role of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.798660/full |
| _version_ | 1798024226226044928 |
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| author | Shu-Ting Song Shu-Ting Song Meng-Li Wu Meng-Li Wu Hai-Jiao Zhang Xiao Su Jian-Hua Wang Jian-Hua Wang |
| author_facet | Shu-Ting Song Shu-Ting Song Meng-Li Wu Meng-Li Wu Hai-Jiao Zhang Xiao Su Jian-Hua Wang Jian-Hua Wang |
| author_sort | Shu-Ting Song |
| collection | DOAJ |
| description | Mast cells (MCs) are strategically located at the host-environment interface and their non-allergic roles in the immune-surveillance of pathogens have recently gained more attention. However, MC-caused detrimental regulation of immune inflammations can promote viral invasion. Currently, the role of MCs in retroviral infection remains elusive. We have recently proved that human gut MCs could capture and transfer HIV-1 to CD4+ T cells for promoting viral spread; MC-released histamine augments HIV-1-induced functional polarization of dendritic cells to cause immunosuppression via stimulating the differentiation of regulatory T cells. In this study, we used a murine model of MuLV/Friend virus infection to address MC role in acute retroviral infection in vivo. The acute infection of MuLV/Friend virus could be established in C57BL/6 wild type mice, but viral acquisition showed low efficiency in C57BL/6-KitW–sh/W–sh (Sash) mice which lack MCs. In mechanism, we found that MuLV/Friend virus triggered MC activation for degranulation; MC degranulation subsequently activated the granulocyte-like myeloid derived suppressive cells (G-MDSCs) to inhibit CD8+ T cells- and NK cells-mediated antiviral immune responses. The reconstruction of MCs in Sash mice promoted acute retroviral infection by regulating G-MDSCs functions and antiviral immune responses. Importantly, the administration of MC stabilizers to block cell degranulation elevated antiviral immune response and consequently suppressed retrovirus infection. This study uncovers a specific role of MCs in acute retroviral infection and elucidates the underlying immune-mechanisms. Targeting MCs may provide a novel approach for controlling acute infection by retroviruses. |
| first_indexed | 2024-04-11T17:58:58Z |
| format | Article |
| id | doaj.art-b82b12b8b6644b9d97b0dc875fe438a9 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-11T17:58:58Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-b82b12b8b6644b9d97b0dc875fe438a92022-12-22T04:10:35ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-02-011310.3389/fmicb.2022.798660798660Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral InfectionShu-Ting Song0Shu-Ting Song1Meng-Li Wu2Meng-Li Wu3Hai-Jiao Zhang4Xiao Su5Jian-Hua Wang6Jian-Hua Wang7Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, ChinaCollege of Life Science, Henan Normal University, Xinxiang, ChinaState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, ChinaInstitut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, ChinaGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaMast cells (MCs) are strategically located at the host-environment interface and their non-allergic roles in the immune-surveillance of pathogens have recently gained more attention. However, MC-caused detrimental regulation of immune inflammations can promote viral invasion. Currently, the role of MCs in retroviral infection remains elusive. We have recently proved that human gut MCs could capture and transfer HIV-1 to CD4+ T cells for promoting viral spread; MC-released histamine augments HIV-1-induced functional polarization of dendritic cells to cause immunosuppression via stimulating the differentiation of regulatory T cells. In this study, we used a murine model of MuLV/Friend virus infection to address MC role in acute retroviral infection in vivo. The acute infection of MuLV/Friend virus could be established in C57BL/6 wild type mice, but viral acquisition showed low efficiency in C57BL/6-KitW–sh/W–sh (Sash) mice which lack MCs. In mechanism, we found that MuLV/Friend virus triggered MC activation for degranulation; MC degranulation subsequently activated the granulocyte-like myeloid derived suppressive cells (G-MDSCs) to inhibit CD8+ T cells- and NK cells-mediated antiviral immune responses. The reconstruction of MCs in Sash mice promoted acute retroviral infection by regulating G-MDSCs functions and antiviral immune responses. Importantly, the administration of MC stabilizers to block cell degranulation elevated antiviral immune response and consequently suppressed retrovirus infection. This study uncovers a specific role of MCs in acute retroviral infection and elucidates the underlying immune-mechanisms. Targeting MCs may provide a novel approach for controlling acute infection by retroviruses.https://www.frontiersin.org/articles/10.3389/fmicb.2022.798660/fullmast celldegranulationretrovirusacute infectionMDSC (myeloid-derived suppressor cell) |
| spellingShingle | Shu-Ting Song Shu-Ting Song Meng-Li Wu Meng-Li Wu Hai-Jiao Zhang Xiao Su Jian-Hua Wang Jian-Hua Wang Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection Frontiers in Microbiology mast cell degranulation retrovirus acute infection MDSC (myeloid-derived suppressor cell) |
| title | Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection |
| title_full | Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection |
| title_fullStr | Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection |
| title_full_unstemmed | Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection |
| title_short | Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection |
| title_sort | mast cell activation triggered by retrovirus promotes acute viral infection |
| topic | mast cell degranulation retrovirus acute infection MDSC (myeloid-derived suppressor cell) |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.798660/full |
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