Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles
Ring-opening reaction via selective cleavage of C–C bond is a powerful strategy to increase molecular complexity. Here the authors present the facile synthesis of chiral 1,5- and 1,6-dinitriles via the radical-mediated ring-opening and enantioselective cyanation of cycloketone oxime esters.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13369-x |
| _version_ | 1818977746156519424 |
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| author | Tao Wang Yi-Ning Wang Rui Wang Bo-Chao Zhang Chi Yang Yan-Lin Li Xi-Sheng Wang |
| author_facet | Tao Wang Yi-Ning Wang Rui Wang Bo-Chao Zhang Chi Yang Yan-Lin Li Xi-Sheng Wang |
| author_sort | Tao Wang |
| collection | DOAJ |
| description | Ring-opening reaction via selective cleavage of C–C bond is a powerful strategy to increase molecular complexity. Here the authors present the facile synthesis of chiral 1,5- and 1,6-dinitriles via the radical-mediated ring-opening and enantioselective cyanation of cycloketone oxime esters. |
| first_indexed | 2024-12-20T16:32:38Z |
| format | Article |
| id | doaj.art-b82b8cd2c3604c3785954d336db962f0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:32:38Z |
| publishDate | 2019-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b82b8cd2c3604c3785954d336db962f02022-12-21T19:33:14ZengNature PortfolioNature Communications2041-17232019-11-011011910.1038/s41467-019-13369-xEnantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitrilesTao Wang0Yi-Ning Wang1Rui Wang2Bo-Chao Zhang3Chi Yang4Yan-Lin Li5Xi-Sheng Wang6Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of ChinaRing-opening reaction via selective cleavage of C–C bond is a powerful strategy to increase molecular complexity. Here the authors present the facile synthesis of chiral 1,5- and 1,6-dinitriles via the radical-mediated ring-opening and enantioselective cyanation of cycloketone oxime esters.https://doi.org/10.1038/s41467-019-13369-x |
| spellingShingle | Tao Wang Yi-Ning Wang Rui Wang Bo-Chao Zhang Chi Yang Yan-Lin Li Xi-Sheng Wang Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles Nature Communications |
| title | Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles |
| title_full | Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles |
| title_fullStr | Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles |
| title_full_unstemmed | Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles |
| title_short | Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles |
| title_sort | enantioselective cyanation via radical mediated c c single bond cleavage for synthesis of chiral dinitriles |
| url | https://doi.org/10.1038/s41467-019-13369-x |
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