Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities
Naringin and naringenin are the main bioactive polyphenols in citrus fruits, the consumption of which is beneficial for human health and has been practiced since ancient times. Numerous studies have reported these substances’ antioxidant and antiandrogenic properties, as well as their ability to pro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/7/1686 |
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| author | Jolita Stabrauskiene Dalia M. Kopustinskiene Robertas Lazauskas Jurga Bernatoniene |
| author_facet | Jolita Stabrauskiene Dalia M. Kopustinskiene Robertas Lazauskas Jurga Bernatoniene |
| author_sort | Jolita Stabrauskiene |
| collection | DOAJ |
| description | Naringin and naringenin are the main bioactive polyphenols in citrus fruits, the consumption of which is beneficial for human health and has been practiced since ancient times. Numerous studies have reported these substances’ antioxidant and antiandrogenic properties, as well as their ability to protect from inflammation and cancer, in various in vitro and in vivo experimental models in animals and humans. Naringin and naringenin can suppress cancer development in various body parts, alleviating the conditions of cancer patients by acting as effective alternative supplementary remedies. Their anticancer activities are pleiotropic, and they can modulate different cellular signaling pathways, suppress cytokine and growth factor production and arrest the cell cycle. In this narrative review, we discuss the effects of naringin and naringenin on inflammation, apoptosis, proliferation, angiogenesis, metastasis and invasion processes and their potential to become innovative and safe anticancer drugs. |
| first_indexed | 2024-03-09T10:22:32Z |
| format | Article |
| id | doaj.art-b832097fbef04029aadc48a9a3e4f9be |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:22:32Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b832097fbef04029aadc48a9a3e4f9be2023-12-01T21:56:17ZengMDPI AGBiomedicines2227-90592022-07-01107168610.3390/biomedicines10071686Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer ActivitiesJolita Stabrauskiene0Dalia M. Kopustinskiene1Robertas Lazauskas2Jurga Bernatoniene3Department of Drug Technology and Social Pharmacy, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, LithuaniaInstitute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, LithuaniaInstitute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, LT-50161 Kaunas, LithuaniaDepartment of Drug Technology and Social Pharmacy, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, LithuaniaNaringin and naringenin are the main bioactive polyphenols in citrus fruits, the consumption of which is beneficial for human health and has been practiced since ancient times. Numerous studies have reported these substances’ antioxidant and antiandrogenic properties, as well as their ability to protect from inflammation and cancer, in various in vitro and in vivo experimental models in animals and humans. Naringin and naringenin can suppress cancer development in various body parts, alleviating the conditions of cancer patients by acting as effective alternative supplementary remedies. Their anticancer activities are pleiotropic, and they can modulate different cellular signaling pathways, suppress cytokine and growth factor production and arrest the cell cycle. In this narrative review, we discuss the effects of naringin and naringenin on inflammation, apoptosis, proliferation, angiogenesis, metastasis and invasion processes and their potential to become innovative and safe anticancer drugs.https://www.mdpi.com/2227-9059/10/7/1686naringinnaringeninflavonoidscancercellular signaling pathways |
| spellingShingle | Jolita Stabrauskiene Dalia M. Kopustinskiene Robertas Lazauskas Jurga Bernatoniene Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities Biomedicines naringin naringenin flavonoids cancer cellular signaling pathways |
| title | Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities |
| title_full | Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities |
| title_fullStr | Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities |
| title_full_unstemmed | Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities |
| title_short | Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities |
| title_sort | naringin and naringenin their mechanisms of action and the potential anticancer activities |
| topic | naringin naringenin flavonoids cancer cellular signaling pathways |
| url | https://www.mdpi.com/2227-9059/10/7/1686 |
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