Somatic intronic TP53 c.375+5G mutations are a recurrent but under‐recognized mode of TP53 inactivation

Somatic intronic TP53 c.375+5G mutations are a recurrent but under‐recognized mode of TP53 inactivation

Abstract TP53 is one of the most ubiquitously altered genes in human cancer. The biological impact of rare variants, particularly those located within noncoding regions, remains poorly understood. From interrogation of clinical massively parallel sequencing data from over 55,000 tumors, which includ...

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Bibliographic Details
Main Authors: M Herman Chui, Ciyu Yang, Nikita Mehta, Vikas Rai, Ahmet Zehir, Amir Momeni Boroujeni, Marc Ladanyi, Diana Mandelker
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:The Journal of Pathology: Clinical Research
Subjects:
p53
TP53
intronic mutation
pathogenic variant
cancer
Online Access:https://doi.org/10.1002/cjp2.242

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