Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent
Liang-Jun Yan Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USA Abstract: 5-Methoxyindole-2-carboxylic acid (MICA) is a potent hypoglycemic agent that inhibits gluconeogenesis in the liver. It is also a well-kn...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-05-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/reexploring-5-methoxyindole-2-carboxylic-acid-mica-as-a-potential-anti-peer-reviewed-article-DMSO |
| _version_ | 1797935638135177216 |
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| author | Yan LJ |
| author_facet | Yan LJ |
| author_sort | Yan LJ |
| collection | DOAJ |
| description | Liang-Jun Yan Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USA Abstract: 5-Methoxyindole-2-carboxylic acid (MICA) is a potent hypoglycemic agent that inhibits gluconeogenesis in the liver. It is also a well-known inhibitor of mitochondrial dihydrolipoamide dehydrogenase. MICA was extensively studied in the 1960s and 1970s and was once tested for its antidiabetic effect in diabetic Chinese hamsters, whereby MICA was shown to exhibit pronounced glucose-lowering ability while also leading to increased rate of death of the diabetic animals. Since then, MICA’s potential ability in lowering blood glucose in diabetes has never been revisited. In my opinion, MICA should be comprehensively reexplored for its antidiabetic properties in a variety of rodent diabetes models. For a given animal model, its dose-dependent effect and the effects of different routes of administrations as well as its synergistic effects with other glucose-lowering drugs should also be investigated. More studies in the future on this chemical may provide novel insights into its role as an antidiabetic agent. Keywords: 5-methoxyindole-2-carboxylic acid, antidiabetic, diabetes, dihydrolipoamide dehydrogenase, gluconeogenesis, mitochondria |
| first_indexed | 2024-04-10T18:17:15Z |
| format | Article |
| id | doaj.art-b833a3af5e924b689350ea6d68a25d01 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:17:15Z |
| publishDate | 2018-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-b833a3af5e924b689350ea6d68a25d012023-02-02T08:30:06ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072018-05-01Volume 1118318638139Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agentYan LJLiang-Jun Yan Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, USA Abstract: 5-Methoxyindole-2-carboxylic acid (MICA) is a potent hypoglycemic agent that inhibits gluconeogenesis in the liver. It is also a well-known inhibitor of mitochondrial dihydrolipoamide dehydrogenase. MICA was extensively studied in the 1960s and 1970s and was once tested for its antidiabetic effect in diabetic Chinese hamsters, whereby MICA was shown to exhibit pronounced glucose-lowering ability while also leading to increased rate of death of the diabetic animals. Since then, MICA’s potential ability in lowering blood glucose in diabetes has never been revisited. In my opinion, MICA should be comprehensively reexplored for its antidiabetic properties in a variety of rodent diabetes models. For a given animal model, its dose-dependent effect and the effects of different routes of administrations as well as its synergistic effects with other glucose-lowering drugs should also be investigated. More studies in the future on this chemical may provide novel insights into its role as an antidiabetic agent. Keywords: 5-methoxyindole-2-carboxylic acid, antidiabetic, diabetes, dihydrolipoamide dehydrogenase, gluconeogenesis, mitochondriahttps://www.dovepress.com/reexploring-5-methoxyindole-2-carboxylic-acid-mica-as-a-potential-anti-peer-reviewed-article-DMSO5-methoxyindole-2-carboxylic acidanti-diabeticdiabetesdihydrolipoamide dehydrogenasegluconeogenesismitochondria |
| spellingShingle | Yan LJ Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent Diabetes, Metabolic Syndrome and Obesity 5-methoxyindole-2-carboxylic acid anti-diabetic diabetes dihydrolipoamide dehydrogenase gluconeogenesis mitochondria |
| title | Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent |
| title_full | Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent |
| title_fullStr | Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent |
| title_full_unstemmed | Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent |
| title_short | Reexploring 5-methoxyindole-2-carboxylic acid (MICA) as a potential antidiabetic agent |
| title_sort | reexploring 5 methoxyindole 2 carboxylic acid mica as a potential antidiabetic agent |
| topic | 5-methoxyindole-2-carboxylic acid anti-diabetic diabetes dihydrolipoamide dehydrogenase gluconeogenesis mitochondria |
| url | https://www.dovepress.com/reexploring-5-methoxyindole-2-carboxylic-acid-mica-as-a-potential-anti-peer-reviewed-article-DMSO |
| work_keys_str_mv | AT yanlj reexploring5methoxyindole2carboxylicacidmicaasapotentialantidiabeticagent |