Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy
Background: Psoriasis Vulgaris is an autoimmune disease characterized by chronic skin inflammation and epidermal hyperplasia. Psoriasis Area Severity Index (PASI) score is one of the assessments to measure the psoriasis severity. Oral methotrexate is one of the effective therapies for psoriasis pati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Indonesian |
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Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga
2022-11-01
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| Series: | Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/BIKK/article/view/32410 |
| _version_ | 1797506050354577408 |
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| author | Ervina Rosmarwati Nurrachmat Mulianto Bobby Febrianto Dita Eka Novriana Siti Efrida Fiqnasyani |
| author_facet | Ervina Rosmarwati Nurrachmat Mulianto Bobby Febrianto Dita Eka Novriana Siti Efrida Fiqnasyani |
| author_sort | Ervina Rosmarwati |
| collection | DOAJ |
| description | Background: Psoriasis Vulgaris is an autoimmune disease characterized by chronic skin inflammation and epidermal hyperplasia. Psoriasis Area Severity Index (PASI) score is one of the assessments to measure the psoriasis severity. Oral methotrexate is one of the effective therapies for psoriasis patients. Narrow Band-Ultraviolet B (NB-UVB) phototherapy is an adjunctive psoriasis therapy given concurrently with oral methotrexate. Purpose: Determine the difference in Psoriasis Area Severity Index (PASI) scores between Psoriasis Vulgaris patients treated with oral methotrexate and a combination of oral methotrexate and NB-UVB phototherapy. Methods: This observational analytic study was conducted at the Dermatology and Venereology Clinic, Dr. Moewardi General Hospital Surakarta. The patients received oral methotrexate and a combination of oral methotrexate and and Narrow Band-Ultraviolet B (NB-UVB) phototherapy. A retrospective study of medical records was conducted to determine the patient's PASI score before the therapies and 3 months after. All data were analyzed with the Shapiro Wilk normality test and the independent T-test. A p-value was <0.05, and it was considered significant. Result: The mean of decreased PASI scores in the oral methotrexate group was (6.00 +2.47) and (6.08 +2.17) in the combination therapy group. Based on the statistical test results from the 24 subjects, it was found that the PASI score decreased (p=0.931). Conclusion: There was no significant difference in the decrease in PASI between the oral methotrexate group and the combination therapy group. The mean reduction of PASI scores was more significant in the combination therapy than in the methotrexate group |
| first_indexed | 2024-03-10T04:27:04Z |
| format | Article |
| id | doaj.art-b83486305db842e3ac163dcecd257dc9 |
| institution | Directory Open Access Journal |
| issn | 1978-4279 2549-4082 |
| language | Indonesian |
| last_indexed | 2024-03-10T04:27:04Z |
| publishDate | 2022-11-01 |
| publisher | Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga |
| record_format | Article |
| series | Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) |
| spelling | doaj.art-b83486305db842e3ac163dcecd257dc92023-11-23T06:35:52ZindDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas AirlanggaBerkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology)1978-42792549-40822022-11-0134316917310.20473/bikk.V34.3.2022.169-17326579Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) PhototherapyErvina Rosmarwati0Nurrachmat Mulianto1Bobby Febrianto2Dita Eka Novriana3Siti Efrida Fiqnasyani4https://orcid.org/0000-0002-0687-1603Recidency Program in Dermatovenereology Departement, Dr. Moewardi General Hospital/Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia2Dermatovenereology Departement, Dr. Moewardi General Hospital/Faculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaResidency Program in Dermatovenereology Departement, Dr. Moewardi General Hospital/Faculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaResidency Program in Dermatovenereology Departement, Dr. Moewardi General Hospital/Faculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaResidency Program in Dermatovenereology Departement, Dr. Moewardi General Hospital/Faculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaBackground: Psoriasis Vulgaris is an autoimmune disease characterized by chronic skin inflammation and epidermal hyperplasia. Psoriasis Area Severity Index (PASI) score is one of the assessments to measure the psoriasis severity. Oral methotrexate is one of the effective therapies for psoriasis patients. Narrow Band-Ultraviolet B (NB-UVB) phototherapy is an adjunctive psoriasis therapy given concurrently with oral methotrexate. Purpose: Determine the difference in Psoriasis Area Severity Index (PASI) scores between Psoriasis Vulgaris patients treated with oral methotrexate and a combination of oral methotrexate and NB-UVB phototherapy. Methods: This observational analytic study was conducted at the Dermatology and Venereology Clinic, Dr. Moewardi General Hospital Surakarta. The patients received oral methotrexate and a combination of oral methotrexate and and Narrow Band-Ultraviolet B (NB-UVB) phototherapy. A retrospective study of medical records was conducted to determine the patient's PASI score before the therapies and 3 months after. All data were analyzed with the Shapiro Wilk normality test and the independent T-test. A p-value was <0.05, and it was considered significant. Result: The mean of decreased PASI scores in the oral methotrexate group was (6.00 +2.47) and (6.08 +2.17) in the combination therapy group. Based on the statistical test results from the 24 subjects, it was found that the PASI score decreased (p=0.931). Conclusion: There was no significant difference in the decrease in PASI between the oral methotrexate group and the combination therapy group. The mean reduction of PASI scores was more significant in the combination therapy than in the methotrexate grouphttps://e-journal.unair.ac.id/BIKK/article/view/32410phototherapymethotrexatepsoriasis vulgarispasi scorenb-uvb |
| spellingShingle | Ervina Rosmarwati Nurrachmat Mulianto Bobby Febrianto Dita Eka Novriana Siti Efrida Fiqnasyani Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) phototherapy methotrexate psoriasis vulgaris pasi score nb-uvb |
| title | Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy |
| title_full | Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy |
| title_fullStr | Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy |
| title_full_unstemmed | Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy |
| title_short | Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy |
| title_sort | comparison of psoriasis area and severity index pasi scores in patients treated with oral methotrexate and a combination of oral methotrexate and narrow band ultraviolet b nb uvb phototherapy |
| topic | phototherapy methotrexate psoriasis vulgaris pasi score nb-uvb |
| url | https://e-journal.unair.ac.id/BIKK/article/view/32410 |
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