Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial
Abstract Background This study aimed to compare the effects of melatonin, dexmedetomidine, and gabapentin on postoperative pain and anxiety following laminectomy. Methods In this randomized clinical trial, 99 patients aged 40–60 years old with American Society of Anesthesiologists physical status I-...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
|
| Series: | BMC Anesthesiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12871-022-01851-x |
| _version_ | 1798029866296147968 |
|---|---|
| author | Reza Jouybar Somayeh Kazemifar Naeimehossadat Asmarian Ali Karami Saeed Khademi |
| author_facet | Reza Jouybar Somayeh Kazemifar Naeimehossadat Asmarian Ali Karami Saeed Khademi |
| author_sort | Reza Jouybar |
| collection | DOAJ |
| description | Abstract Background This study aimed to compare the effects of melatonin, dexmedetomidine, and gabapentin on postoperative pain and anxiety following laminectomy. Methods In this randomized clinical trial, 99 patients aged 40–60 years old with American Society of Anesthesiologists physical status I-II undergoing laminectomy were divided into three groups receiving 600mg gabapentin (group G), 10mg melatonin (group M), or starch tablets (group D). The Hospital Anxiety and Depression Scale (HADS) was used to measure postoperative anxiety while a Visual Analogue Scale (VAS) was employed to measure pain severity. Patients’ satisfaction with pain treatment was also measured together with the frequency of nausea and vomiting. Results The postoperative HADS decreased in all groups over time. Time and group had no significant interaction effect on the HADS score. Patients in the melatonin group had lower HADS at 2 and 6h after surgery. According to the VAS, the groups significantly differed in pain scores 6 and 24h after surgery. Lower VAS scores were observed 6h after surgery in the dexmedetomidine group compared with the gabapentin group and 24h after surgery in the dexmedetomidine group compared with the gabapentin and melatonin groups. Narcotic requirements, patients’ satisfaction, and vital sign changes did not significantly vary among the groups. Notably, patients in the melatonin group had less nausea and vomiting. Trial registration: This study was registered in the Iranian Registry of Clinical Trials (No. IRCT20141009019470N82, 29.06.2019) where the trial protocol could be accessed. Conclusion Melatonin is effective as a postoperative anti-anxiety drug. Dexmedetomidine is useful in reducing postoperative pain. |
| first_indexed | 2024-04-11T19:32:09Z |
| format | Article |
| id | doaj.art-b834aace63a6426e90f527386b51a6ae |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-04-11T19:32:09Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-b834aace63a6426e90f527386b51a6ae2022-12-22T04:06:58ZengBMCBMC Anesthesiology1471-22532022-10-012211910.1186/s12871-022-01851-xComparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trialReza Jouybar0Somayeh Kazemifar1Naeimehossadat Asmarian2Ali Karami3Saeed Khademi4Anesthesiology and Critical Care Research Center, Shiraz University of Medical SciencesAnesthesiology and Critical Care Research Center, Shiraz University of Medical SciencesAnesthesiology and Critical Care Research Center, Shiraz University of Medical SciencesAnesthesiology and Critical Care Research Center, Shiraz University of Medical SciencesAnesthesiology and Critical Care Research Center, Shiraz University of Medical SciencesAbstract Background This study aimed to compare the effects of melatonin, dexmedetomidine, and gabapentin on postoperative pain and anxiety following laminectomy. Methods In this randomized clinical trial, 99 patients aged 40–60 years old with American Society of Anesthesiologists physical status I-II undergoing laminectomy were divided into three groups receiving 600mg gabapentin (group G), 10mg melatonin (group M), or starch tablets (group D). The Hospital Anxiety and Depression Scale (HADS) was used to measure postoperative anxiety while a Visual Analogue Scale (VAS) was employed to measure pain severity. Patients’ satisfaction with pain treatment was also measured together with the frequency of nausea and vomiting. Results The postoperative HADS decreased in all groups over time. Time and group had no significant interaction effect on the HADS score. Patients in the melatonin group had lower HADS at 2 and 6h after surgery. According to the VAS, the groups significantly differed in pain scores 6 and 24h after surgery. Lower VAS scores were observed 6h after surgery in the dexmedetomidine group compared with the gabapentin group and 24h after surgery in the dexmedetomidine group compared with the gabapentin and melatonin groups. Narcotic requirements, patients’ satisfaction, and vital sign changes did not significantly vary among the groups. Notably, patients in the melatonin group had less nausea and vomiting. Trial registration: This study was registered in the Iranian Registry of Clinical Trials (No. IRCT20141009019470N82, 29.06.2019) where the trial protocol could be accessed. Conclusion Melatonin is effective as a postoperative anti-anxiety drug. Dexmedetomidine is useful in reducing postoperative pain.https://doi.org/10.1186/s12871-022-01851-xMelatoninDexmedetomidineGabapentinPainAnxietyLaminectomy |
| spellingShingle | Reza Jouybar Somayeh Kazemifar Naeimehossadat Asmarian Ali Karami Saeed Khademi Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial BMC Anesthesiology Melatonin Dexmedetomidine Gabapentin Pain Anxiety Laminectomy |
| title | Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial |
| title_full | Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial |
| title_fullStr | Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial |
| title_full_unstemmed | Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial |
| title_short | Comparison of the effect of melatonin, dexmedetomidine, and gabapentin on reduction of postoperative pain and anxiety following laminectomy: a randomized clinical trial |
| title_sort | comparison of the effect of melatonin dexmedetomidine and gabapentin on reduction of postoperative pain and anxiety following laminectomy a randomized clinical trial |
| topic | Melatonin Dexmedetomidine Gabapentin Pain Anxiety Laminectomy |
| url | https://doi.org/10.1186/s12871-022-01851-x |
| work_keys_str_mv | AT rezajouybar comparisonoftheeffectofmelatonindexmedetomidineandgabapentinonreductionofpostoperativepainandanxietyfollowinglaminectomyarandomizedclinicaltrial AT somayehkazemifar comparisonoftheeffectofmelatonindexmedetomidineandgabapentinonreductionofpostoperativepainandanxietyfollowinglaminectomyarandomizedclinicaltrial AT naeimehossadatasmarian comparisonoftheeffectofmelatonindexmedetomidineandgabapentinonreductionofpostoperativepainandanxietyfollowinglaminectomyarandomizedclinicaltrial AT alikarami comparisonoftheeffectofmelatonindexmedetomidineandgabapentinonreductionofpostoperativepainandanxietyfollowinglaminectomyarandomizedclinicaltrial AT saeedkhademi comparisonoftheeffectofmelatonindexmedetomidineandgabapentinonreductionofpostoperativepainandanxietyfollowinglaminectomyarandomizedclinicaltrial |