Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective
Apoptotic death and apoptotic mimicry are defined respectively as a non-accidental death and as the mimicking of an apoptotic-cell phenotype, usually by phosphatidylserine exposure. In the case of the murine infection by Leishmania spp, apoptotic death has been described in promastigotes and apoptot...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00096/full |
| _version_ | 1818258433606942720 |
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| author | Charbel eEl-Hani Valeria Matos Borges Valeria Matos Borges Valeria Matos Borges João Luiz Mendes Wanderley Marcello André Barcinski |
| author_facet | Charbel eEl-Hani Valeria Matos Borges Valeria Matos Borges Valeria Matos Borges João Luiz Mendes Wanderley Marcello André Barcinski |
| author_sort | Charbel eEl-Hani |
| collection | DOAJ |
| description | Apoptotic death and apoptotic mimicry are defined respectively as a non-accidental death and as the mimicking of an apoptotic-cell phenotype, usually by phosphatidylserine exposure. In the case of the murine infection by Leishmania spp, apoptotic death has been described in promastigotes and apoptotic mimicry in amastigotes. In both situations they are important events of the experimental murine infection by this parasite. In the present review we discuss what features we need to consider if we want to establish if a behavior shown by Leishmania is altruistic or not: does the behavior increases the fitness of organisms other than the one showing it? Does this behavior have a cost for the actor? If we manage to show that a given behavior is costly for the actor and beneficial for the recipient of the action, we will be able to establish it as altruistic. From this perspective, we can argue that apoptotic-like death and apoptotic mimicry are both altruistic with the latter representing a weaker altruistic behavior than the former. |
| first_indexed | 2024-12-12T17:59:28Z |
| format | Article |
| id | doaj.art-b8374aa9c2eb49978777406a68432d4f |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-12T17:59:28Z |
| publishDate | 2012-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-b8374aa9c2eb49978777406a68432d4f2022-12-22T00:16:38ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882012-07-01210.3389/fcimb.2012.0009623757Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspectiveCharbel eEl-Hani0Valeria Matos Borges1Valeria Matos Borges2Valeria Matos Borges3João Luiz Mendes Wanderley4Marcello André Barcinski5Universidade Federal da BahiaInstituto de Pesquisas Gonçalo MunizUniversidade Federal da BahiaInstituto Nacional de Ciência e Tecnologia em ImunologiaUniversidade Federal do Rio de JaneiroInstituto Oswaldo CruzApoptotic death and apoptotic mimicry are defined respectively as a non-accidental death and as the mimicking of an apoptotic-cell phenotype, usually by phosphatidylserine exposure. In the case of the murine infection by Leishmania spp, apoptotic death has been described in promastigotes and apoptotic mimicry in amastigotes. In both situations they are important events of the experimental murine infection by this parasite. In the present review we discuss what features we need to consider if we want to establish if a behavior shown by Leishmania is altruistic or not: does the behavior increases the fitness of organisms other than the one showing it? Does this behavior have a cost for the actor? If we manage to show that a given behavior is costly for the actor and beneficial for the recipient of the action, we will be able to establish it as altruistic. From this perspective, we can argue that apoptotic-like death and apoptotic mimicry are both altruistic with the latter representing a weaker altruistic behavior than the former.http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00096/fullApoptosisevolutionAltruismApoptotic mimicryLeishmania sppUnicellular parasites |
| spellingShingle | Charbel eEl-Hani Valeria Matos Borges Valeria Matos Borges Valeria Matos Borges João Luiz Mendes Wanderley Marcello André Barcinski Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective Frontiers in Cellular and Infection Microbiology Apoptosis evolution Altruism Apoptotic mimicry Leishmania spp Unicellular parasites |
| title | Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective |
| title_full | Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective |
| title_fullStr | Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective |
| title_full_unstemmed | Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective |
| title_short | Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective |
| title_sort | apoptosis and apoptotic mimicry in leishmania an evolutionary perspective |
| topic | Apoptosis evolution Altruism Apoptotic mimicry Leishmania spp Unicellular parasites |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00096/full |
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