Cutaneous manifestations in disorders of hepatobiliary system
Background: Hepatobiliary diseases are associated with various mucocutaneous changes that are directly and indirectly associated with these diseases. There is a dearth of studies from India dealing with cutaneous manifestations in liver disorders. Aim: This study was conducted to know the spectrum o...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Indian Dermatology Online Journal |
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| Online Access: | http://www.idoj.in/article.asp?issn=2229-5178;year=2017;volume=8;issue=1;spage=9;epage=15;aulast=Godara |
| _version_ | 1819209864658812928 |
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| author | Shashi K Godara Devinder M Thappa Biju Pottakkatt Abdoul Hamide Jagadisan Barath Malathi Munisamy Minu J Chiramel |
| author_facet | Shashi K Godara Devinder M Thappa Biju Pottakkatt Abdoul Hamide Jagadisan Barath Malathi Munisamy Minu J Chiramel |
| author_sort | Shashi K Godara |
| collection | DOAJ |
| description | Background: Hepatobiliary diseases are associated with various mucocutaneous changes that are directly and indirectly associated with these diseases. There is a dearth of studies from India dealing with cutaneous manifestations in liver disorders. Aim: This study was conducted to know the spectrum of cutaneous changes and their correlation with liver function tests in patients with disorders of hepatobiliary system. Methods: This was a descriptive study conducted among in patients and outpatients with primary hepatobiliary disorders at a tertiary care center in South India. Detailed history taking and examination was done. Visual analog score (VAS) and 5D itch score was employed to quantify pruritus. Correlation of liver function tests with pruritus and comparison of skin changes in the major disease groups was attempted. Results: A total of 303 patients were recruited. Hepatic mass/malignancy followed by nonalcoholic liver disease were the most common diagnoses. Icterus followed by pruritus were the most common cutaneous complaints. The mean VAS and 5D itch scores among the patients with pruritus were 4.7 ± 1.9 and 13.6 ± 4.9. The most common mucocutaneous findings observed were icterus (241 patients; 79.5%), ichthyosis/xerosis (172 patients; 56.7%), pallor (131 patients; 43.2%), excoriations (118 patients; 38.9%), hyperpigmented palmar creases (118 patients; 38.9%), clubbing (113 patients; 37.2%), and pedal edema (85 patients; 28%).There was statistically significant correlation between serum bilirubin levels and pruritus. Conclusion: The common mucocutaneous manifestations associated with primary hepatobiliary disorders were icterus, ichthyosis/xerosis, pallor, excoriations, hyperpigmented palmar creases, clubbing, and pedal edema. |
| first_indexed | 2024-12-23T06:02:04Z |
| format | Article |
| id | doaj.art-b8385731de4d4ddfb59f308960d972bc |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-12-23T06:02:04Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-b8385731de4d4ddfb59f308960d972bc2022-12-21T17:57:40ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782017-01-018191510.4103/2229-5178.198760Cutaneous manifestations in disorders of hepatobiliary systemShashi K GodaraDevinder M ThappaBiju PottakkattAbdoul HamideJagadisan BarathMalathi MunisamyMinu J ChiramelBackground: Hepatobiliary diseases are associated with various mucocutaneous changes that are directly and indirectly associated with these diseases. There is a dearth of studies from India dealing with cutaneous manifestations in liver disorders. Aim: This study was conducted to know the spectrum of cutaneous changes and their correlation with liver function tests in patients with disorders of hepatobiliary system. Methods: This was a descriptive study conducted among in patients and outpatients with primary hepatobiliary disorders at a tertiary care center in South India. Detailed history taking and examination was done. Visual analog score (VAS) and 5D itch score was employed to quantify pruritus. Correlation of liver function tests with pruritus and comparison of skin changes in the major disease groups was attempted. Results: A total of 303 patients were recruited. Hepatic mass/malignancy followed by nonalcoholic liver disease were the most common diagnoses. Icterus followed by pruritus were the most common cutaneous complaints. The mean VAS and 5D itch scores among the patients with pruritus were 4.7 ± 1.9 and 13.6 ± 4.9. The most common mucocutaneous findings observed were icterus (241 patients; 79.5%), ichthyosis/xerosis (172 patients; 56.7%), pallor (131 patients; 43.2%), excoriations (118 patients; 38.9%), hyperpigmented palmar creases (118 patients; 38.9%), clubbing (113 patients; 37.2%), and pedal edema (85 patients; 28%).There was statistically significant correlation between serum bilirubin levels and pruritus. Conclusion: The common mucocutaneous manifestations associated with primary hepatobiliary disorders were icterus, ichthyosis/xerosis, pallor, excoriations, hyperpigmented palmar creases, clubbing, and pedal edema.http://www.idoj.in/article.asp?issn=2229-5178;year=2017;volume=8;issue=1;spage=9;epage=15;aulast=GodaraHepatitisliver disordersskin changes |
| spellingShingle | Shashi K Godara Devinder M Thappa Biju Pottakkatt Abdoul Hamide Jagadisan Barath Malathi Munisamy Minu J Chiramel Cutaneous manifestations in disorders of hepatobiliary system Indian Dermatology Online Journal Hepatitis liver disorders skin changes |
| title | Cutaneous manifestations in disorders of hepatobiliary system |
| title_full | Cutaneous manifestations in disorders of hepatobiliary system |
| title_fullStr | Cutaneous manifestations in disorders of hepatobiliary system |
| title_full_unstemmed | Cutaneous manifestations in disorders of hepatobiliary system |
| title_short | Cutaneous manifestations in disorders of hepatobiliary system |
| title_sort | cutaneous manifestations in disorders of hepatobiliary system |
| topic | Hepatitis liver disorders skin changes |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2017;volume=8;issue=1;spage=9;epage=15;aulast=Godara |
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