Relationship among number of close friends, subclinical geriatric depression, and subjective cognitive decline based on regional homogeneity of functional magnetic resonance imaging data
The relationship between geriatric depression and dementia has been widely debated, and the neurological mechanisms underlying subjective cognitive decline (SCD) associated with social relationships remain elusive. Subclinical geriatric depression (SGD) is common in patients with SCD, and close frie...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.978611/full |
| _version_ | 1811289365310078976 |
|---|---|
| author | Zhao Zhang Guangfei Li Guangfei Li Zeyu Song Ying Han Xiaoying Tang |
| author_facet | Zhao Zhang Guangfei Li Guangfei Li Zeyu Song Ying Han Xiaoying Tang |
| author_sort | Zhao Zhang |
| collection | DOAJ |
| description | The relationship between geriatric depression and dementia has been widely debated, and the neurological mechanisms underlying subjective cognitive decline (SCD) associated with social relationships remain elusive. Subclinical geriatric depression (SGD) is common in patients with SCD, and close friends (CFs) have a great influence on a person’s social life. Studies have proven that communication or leisure activities with CFs can improve the cognitive performance of elderly. However, it remains unclear whether the engagement of specific brain regions mediates having CFs, SGD, and SCD. In this study, we aimed to assess the association between social relationships (that is, CFs), SGD, and SCD from the perspective of brain function. We examined the data of 66 patients with SCD and 63 normal controls (NC). Compared with NC, SGD was significantly inversely correlated with the number of CFs in the SCD group. We calculated regional homogeneity (ReHo) of functional magnetic resonance imaging (MRI) data of each subject. At a corrected threshold, the right occipital gyrus (SOG.R) and right fusiform gyrus (FFG.R) exhibited positive correlation with SGD in patients with SCD. Mediation analyses to query the inter-relationships between the neural markers and clinical variables exhibited a best fit of the model with CFs → FFG.R → SGD → SOG.R → SCD. These findings suggested a pathway whereby social relationships alter the function of specific brain regions, and SGD may be an early symptom of SCD. We observed that the FFG.R mediate social relationships and SGD, and the abnormality of the SOG.R may be a key factor in the SCD caused by depression. Moreover, a greater number of CFs may reduce the risk of developing SGD. |
| first_indexed | 2024-04-13T03:53:36Z |
| format | Article |
| id | doaj.art-b83891d0e38a41a9b7e9cfcc1373feb3 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T03:53:36Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-b83891d0e38a41a9b7e9cfcc1373feb32022-12-22T03:03:42ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-09-011410.3389/fnagi.2022.978611978611Relationship among number of close friends, subclinical geriatric depression, and subjective cognitive decline based on regional homogeneity of functional magnetic resonance imaging dataZhao Zhang0Guangfei Li1Guangfei Li2Zeyu Song3Ying Han4Xiaoying Tang5Department of Biomedical Engineering, School of Life Sciences, Beijing Institute of Technology, Beijing, ChinaDepartment of Biomedical Engineering, School of Life Sciences, Beijing Institute of Technology, Beijing, ChinaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Biomedical Engineering, School of Life Sciences, Beijing Institute of Technology, Beijing, ChinaDepartment of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, ChinaDepartment of Biomedical Engineering, School of Life Sciences, Beijing Institute of Technology, Beijing, ChinaThe relationship between geriatric depression and dementia has been widely debated, and the neurological mechanisms underlying subjective cognitive decline (SCD) associated with social relationships remain elusive. Subclinical geriatric depression (SGD) is common in patients with SCD, and close friends (CFs) have a great influence on a person’s social life. Studies have proven that communication or leisure activities with CFs can improve the cognitive performance of elderly. However, it remains unclear whether the engagement of specific brain regions mediates having CFs, SGD, and SCD. In this study, we aimed to assess the association between social relationships (that is, CFs), SGD, and SCD from the perspective of brain function. We examined the data of 66 patients with SCD and 63 normal controls (NC). Compared with NC, SGD was significantly inversely correlated with the number of CFs in the SCD group. We calculated regional homogeneity (ReHo) of functional magnetic resonance imaging (MRI) data of each subject. At a corrected threshold, the right occipital gyrus (SOG.R) and right fusiform gyrus (FFG.R) exhibited positive correlation with SGD in patients with SCD. Mediation analyses to query the inter-relationships between the neural markers and clinical variables exhibited a best fit of the model with CFs → FFG.R → SGD → SOG.R → SCD. These findings suggested a pathway whereby social relationships alter the function of specific brain regions, and SGD may be an early symptom of SCD. We observed that the FFG.R mediate social relationships and SGD, and the abnormality of the SOG.R may be a key factor in the SCD caused by depression. Moreover, a greater number of CFs may reduce the risk of developing SGD.https://www.frontiersin.org/articles/10.3389/fnagi.2022.978611/fullnumber of close friendssubjective cognitive declineregional homogeneitymediation effectsubclinical geriatric depression |
| spellingShingle | Zhao Zhang Guangfei Li Guangfei Li Zeyu Song Ying Han Xiaoying Tang Relationship among number of close friends, subclinical geriatric depression, and subjective cognitive decline based on regional homogeneity of functional magnetic resonance imaging data Frontiers in Aging Neuroscience number of close friends subjective cognitive decline regional homogeneity mediation effect subclinical geriatric depression |
| title | Relationship among number of close friends, subclinical geriatric depression, and subjective cognitive decline based on regional homogeneity of functional magnetic resonance imaging data |
| title_full | Relationship among number of close friends, subclinical geriatric depression, and subjective cognitive decline based on regional homogeneity of functional magnetic resonance imaging data |
| title_fullStr | Relationship among number of close friends, subclinical geriatric depression, and subjective cognitive decline based on regional homogeneity of functional magnetic resonance imaging data |
| title_full_unstemmed | Relationship among number of close friends, subclinical geriatric depression, and subjective cognitive decline based on regional homogeneity of functional magnetic resonance imaging data |
| title_short | Relationship among number of close friends, subclinical geriatric depression, and subjective cognitive decline based on regional homogeneity of functional magnetic resonance imaging data |
| title_sort | relationship among number of close friends subclinical geriatric depression and subjective cognitive decline based on regional homogeneity of functional magnetic resonance imaging data |
| topic | number of close friends subjective cognitive decline regional homogeneity mediation effect subclinical geriatric depression |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.978611/full |
| work_keys_str_mv | AT zhaozhang relationshipamongnumberofclosefriendssubclinicalgeriatricdepressionandsubjectivecognitivedeclinebasedonregionalhomogeneityoffunctionalmagneticresonanceimagingdata AT guangfeili relationshipamongnumberofclosefriendssubclinicalgeriatricdepressionandsubjectivecognitivedeclinebasedonregionalhomogeneityoffunctionalmagneticresonanceimagingdata AT guangfeili relationshipamongnumberofclosefriendssubclinicalgeriatricdepressionandsubjectivecognitivedeclinebasedonregionalhomogeneityoffunctionalmagneticresonanceimagingdata AT zeyusong relationshipamongnumberofclosefriendssubclinicalgeriatricdepressionandsubjectivecognitivedeclinebasedonregionalhomogeneityoffunctionalmagneticresonanceimagingdata AT yinghan relationshipamongnumberofclosefriendssubclinicalgeriatricdepressionandsubjectivecognitivedeclinebasedonregionalhomogeneityoffunctionalmagneticresonanceimagingdata AT xiaoyingtang relationshipamongnumberofclosefriendssubclinicalgeriatricdepressionandsubjectivecognitivedeclinebasedonregionalhomogeneityoffunctionalmagneticresonanceimagingdata |