GENOMIC BACKGROUND OF ENTROPION IN FLECKVIEH CATTLE
Runs of homozygosity (ROH) and genome wide association study (GWAS) were used to identify genomic regions of entropion in Austrian Fleckvieh cattle. Entropion is an eye disorder where the eye lids turn inward, causing inflammations, cornea damage or even blindness if left untreated. A total of 196 b...
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Faculty of Agrobitechnical Sciences Osijek
2015-09-01
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| Series: | Poljoprivreda |
| Subjects: | |
| Online Access: | http://poljoprivreda.pfos.hr/upload/publications/poljoprivreda-21-1-sup10.pdf |
| _version_ | 1818331298861678592 |
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| author | Gábor Mészáros Martin Peter Stückler Maja Ferenčaković Johann Sölkner |
| author_facet | Gábor Mészáros Martin Peter Stückler Maja Ferenčaković Johann Sölkner |
| author_sort | Gábor Mészáros |
| collection | DOAJ |
| description | Runs of homozygosity (ROH) and genome wide association study (GWAS) were used to identify genomic regions of entropion in Austrian Fleckvieh cattle. Entropion is an eye disorder where the eye lids turn inward, causing inflammations, cornea damage or even blindness if left untreated. A total of 196 bulls genotyped by BovineSNP50 BeadChip were analysed, nine of which had the disorder confirmed by a veterinarian, ten were unconfirmed and 177 were healthy control animals. Runs of homozygosity analysis highlighted regions on seven chromosomes where the proportion of animals in ROH significantly (p<0.001) differed between cases and controls. None of the 19 genes identified in these regions showed any connection to entropion or eye development. The GWAS study using only cases and controls had a mild peak directly on top of the ITGA9 gene. This gene was previously identified in mice affecting cornea and eye lid development, therefore we consider it being a candidate to influence entropion also in cattle. |
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| id | doaj.art-b83c05a93bac4ec791b89f78a2fca5b0 |
| institution | Directory Open Access Journal |
| issn | 1330-7142 1848-8080 |
| language | English |
| last_indexed | 2024-12-13T13:17:38Z |
| publishDate | 2015-09-01 |
| publisher | Faculty of Agrobitechnical Sciences Osijek |
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| series | Poljoprivreda |
| spelling | doaj.art-b83c05a93bac4ec791b89f78a2fca5b02022-12-21T23:44:29ZengFaculty of Agrobitechnical Sciences OsijekPoljoprivreda1330-71421848-80802015-09-01211 sup485110.18047/poljo.21.1.sup.10GENOMIC BACKGROUND OF ENTROPION IN FLECKVIEH CATTLEGábor Mészáros0Martin Peter Stückler 1Maja Ferenčaković2Johann Sölkner3University Of Natural Resources and Life Sciences, Vienna, Division of Livestock Sciences, Augasse 2-6, 1090, Vienna, AustriaUniversity Of Natural Resources and Life Sciences, Vienna, Division of Livestock Sciences, Augasse 2-6, 1090, Vienna, AustriaUniversity of Zagreb, Department of Animal Science, Svetošimunska 25, HR-10000 Zagreb, Croatia University Of Natural Resources and Life Sciences, Vienna, Division of Livestock Sciences, Augasse 2-6, 1090, Vienna, Austria Runs of homozygosity (ROH) and genome wide association study (GWAS) were used to identify genomic regions of entropion in Austrian Fleckvieh cattle. Entropion is an eye disorder where the eye lids turn inward, causing inflammations, cornea damage or even blindness if left untreated. A total of 196 bulls genotyped by BovineSNP50 BeadChip were analysed, nine of which had the disorder confirmed by a veterinarian, ten were unconfirmed and 177 were healthy control animals. Runs of homozygosity analysis highlighted regions on seven chromosomes where the proportion of animals in ROH significantly (p<0.001) differed between cases and controls. None of the 19 genes identified in these regions showed any connection to entropion or eye development. The GWAS study using only cases and controls had a mild peak directly on top of the ITGA9 gene. This gene was previously identified in mice affecting cornea and eye lid development, therefore we consider it being a candidate to influence entropion also in cattle.http://poljoprivreda.pfos.hr/upload/publications/poljoprivreda-21-1-sup10.pdfcattleSNPGWASruns of homozygosityeye disorder |
| spellingShingle | Gábor Mészáros Martin Peter Stückler Maja Ferenčaković Johann Sölkner GENOMIC BACKGROUND OF ENTROPION IN FLECKVIEH CATTLE Poljoprivreda cattle SNP GWAS runs of homozygosity eye disorder |
| title | GENOMIC BACKGROUND OF ENTROPION IN FLECKVIEH CATTLE |
| title_full | GENOMIC BACKGROUND OF ENTROPION IN FLECKVIEH CATTLE |
| title_fullStr | GENOMIC BACKGROUND OF ENTROPION IN FLECKVIEH CATTLE |
| title_full_unstemmed | GENOMIC BACKGROUND OF ENTROPION IN FLECKVIEH CATTLE |
| title_short | GENOMIC BACKGROUND OF ENTROPION IN FLECKVIEH CATTLE |
| title_sort | genomic background of entropion in fleckvieh cattle |
| topic | cattle SNP GWAS runs of homozygosity eye disorder |
| url | http://poljoprivreda.pfos.hr/upload/publications/poljoprivreda-21-1-sup10.pdf |
| work_keys_str_mv | AT gabormeszaros genomicbackgroundofentropioninfleckviehcattle AT martinpeterstuckler genomicbackgroundofentropioninfleckviehcattle AT majaferencakovic genomicbackgroundofentropioninfleckviehcattle AT johannsolkner genomicbackgroundofentropioninfleckviehcattle |