Mean Platelet Volume Is Related to Cumulative Disease Damage in Patients with Systemic Lupus Erythematosus
Mean platelet volume (MPV), which represents the average platelet size in femtoliters, has emerged as a reliable biomarker in several systemic and chronic disorders. However, its relationship with disease characteristics in large series of patients with systemic lupus erythematosus (SLE) has not bee...
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MDPI AG
2024-03-01
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| Online Access: | https://www.mdpi.com/2075-1729/14/4/428 |
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| author | Yolanda Fernández-Cladera Marta Hernández-Díaz María García-González Juan C. Quevedo-Abeledo Adrián Quevedo-Rodríguez Fuensanta Gómez-Bernal Cristina Gómez-Moreno Candelaria Martín-González Miguel Á. González-Gay Iván Ferraz-Amaro |
| author_facet | Yolanda Fernández-Cladera Marta Hernández-Díaz María García-González Juan C. Quevedo-Abeledo Adrián Quevedo-Rodríguez Fuensanta Gómez-Bernal Cristina Gómez-Moreno Candelaria Martín-González Miguel Á. González-Gay Iván Ferraz-Amaro |
| author_sort | Yolanda Fernández-Cladera |
| collection | DOAJ |
| description | Mean platelet volume (MPV), which represents the average platelet size in femtoliters, has emerged as a reliable biomarker in several systemic and chronic disorders. However, its relationship with disease characteristics in large series of patients with systemic lupus erythematosus (SLE) has not been exhaustively studied to date. In the present work, we aimed to analyze how disease characteristics, including disease activity and cumulative damage, relate to MPV in a well-characterized series of SLE patients. In total, 179 patients with SLE and 181 age- and sex-matched healthy controls were recruited. Complete blood counts including MPV were assessed. Linear multivariable analysis was performed to evaluate the relationship between MPV and SLE disease characteristics, including composite scores of disease activity and damage. MPV was significantly lower in patients with SLE compared to controls after multivariable analysis (beta coefficient, −0.7 [95% confidence interval, −1.1 to −0.3)] fL, <i>p</i> < 0.001). Although the SLEDAI disease activity index was not related to MPV, the SLICC score measuring cumulative disease damage was significantly associated with lower MPV values after adjustment for covariates. Elements of the SLICC score that were associated with lower MPV levels were those pertaining to the kidney, peripheral vascular, and musculoskeletal manifestations of the disease. In conclusion, MPV is lower in patients with SLE compared to matched controls. This MPV downregulation is primarily due to the renal, peripheral vascular and musculoskeletal manifestations of the disease. MPV may represent a biomarker of accrual disease damage in SLE. |
| first_indexed | 2025-03-22T05:58:00Z |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2025-03-22T05:58:00Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
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| series | Life |
| spelling | doaj.art-b83c1e470f6f4bf3838fbfa9b698f4eb2024-04-26T13:33:09ZengMDPI AGLife2075-17292024-03-0114442810.3390/life14040428Mean Platelet Volume Is Related to Cumulative Disease Damage in Patients with Systemic Lupus ErythematosusYolanda Fernández-Cladera0Marta Hernández-Díaz1María García-González2Juan C. Quevedo-Abeledo3Adrián Quevedo-Rodríguez4Fuensanta Gómez-Bernal5Cristina Gómez-Moreno6Candelaria Martín-González7Miguel Á. González-Gay8Iván Ferraz-Amaro9Division of Central Laboratory, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Rheumatology, Hospital Doctor Negrín, 35010 Las Palmas de Gran Canarias, SpainDivision of Rheumatology, Hospital Doctor Negrín, 35010 Las Palmas de Gran Canarias, SpainDivision of Central Laboratory, Hospital Universitario de Canarias, 38320 Tenerife, SpainFundación Jiménez Díaz, School of Nursing of Madrid, Autonomous University of Madrid, 28040 Madrid, SpainDepartment of Internal Medicine, Universidad de La Laguna (ULL), 38200 Tenerife, SpainDivision of Rheumatology, Instituto de Investigación Sanitaria, Fundación Jiménez Díaz, 28040 Madrid, SpainDivision of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, SpainMean platelet volume (MPV), which represents the average platelet size in femtoliters, has emerged as a reliable biomarker in several systemic and chronic disorders. However, its relationship with disease characteristics in large series of patients with systemic lupus erythematosus (SLE) has not been exhaustively studied to date. In the present work, we aimed to analyze how disease characteristics, including disease activity and cumulative damage, relate to MPV in a well-characterized series of SLE patients. In total, 179 patients with SLE and 181 age- and sex-matched healthy controls were recruited. Complete blood counts including MPV were assessed. Linear multivariable analysis was performed to evaluate the relationship between MPV and SLE disease characteristics, including composite scores of disease activity and damage. MPV was significantly lower in patients with SLE compared to controls after multivariable analysis (beta coefficient, −0.7 [95% confidence interval, −1.1 to −0.3)] fL, <i>p</i> < 0.001). Although the SLEDAI disease activity index was not related to MPV, the SLICC score measuring cumulative disease damage was significantly associated with lower MPV values after adjustment for covariates. Elements of the SLICC score that were associated with lower MPV levels were those pertaining to the kidney, peripheral vascular, and musculoskeletal manifestations of the disease. In conclusion, MPV is lower in patients with SLE compared to matched controls. This MPV downregulation is primarily due to the renal, peripheral vascular and musculoskeletal manifestations of the disease. MPV may represent a biomarker of accrual disease damage in SLE.https://www.mdpi.com/2075-1729/14/4/428mean platelet volumesystemic lupus erythematosus |
| spellingShingle | Yolanda Fernández-Cladera Marta Hernández-Díaz María García-González Juan C. Quevedo-Abeledo Adrián Quevedo-Rodríguez Fuensanta Gómez-Bernal Cristina Gómez-Moreno Candelaria Martín-González Miguel Á. González-Gay Iván Ferraz-Amaro Mean Platelet Volume Is Related to Cumulative Disease Damage in Patients with Systemic Lupus Erythematosus Life mean platelet volume systemic lupus erythematosus |
| title | Mean Platelet Volume Is Related to Cumulative Disease Damage in Patients with Systemic Lupus Erythematosus |
| title_full | Mean Platelet Volume Is Related to Cumulative Disease Damage in Patients with Systemic Lupus Erythematosus |
| title_fullStr | Mean Platelet Volume Is Related to Cumulative Disease Damage in Patients with Systemic Lupus Erythematosus |
| title_full_unstemmed | Mean Platelet Volume Is Related to Cumulative Disease Damage in Patients with Systemic Lupus Erythematosus |
| title_short | Mean Platelet Volume Is Related to Cumulative Disease Damage in Patients with Systemic Lupus Erythematosus |
| title_sort | mean platelet volume is related to cumulative disease damage in patients with systemic lupus erythematosus |
| topic | mean platelet volume systemic lupus erythematosus |
| url | https://www.mdpi.com/2075-1729/14/4/428 |
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