Radial Organization in the Mammalian Nucleus
In eukaryotic cells, most of the genetic material is contained within a highly specialized organelle—the nucleus. A large body of evidence indicates that, within the nucleus, chromatinized DNA is spatially organized at multiple length scales. The higher-order organization of chromatin is crucial for...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2020.00033/full |
| _version_ | 1818352049882923008 |
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| author | Nicola Crosetto Magda Bienko |
| author_facet | Nicola Crosetto Magda Bienko |
| author_sort | Nicola Crosetto |
| collection | DOAJ |
| description | In eukaryotic cells, most of the genetic material is contained within a highly specialized organelle—the nucleus. A large body of evidence indicates that, within the nucleus, chromatinized DNA is spatially organized at multiple length scales. The higher-order organization of chromatin is crucial for proper execution of multiple genome functions, including DNA replication and transcription. Here, we review our current knowledge on the spatial organization of chromatin in the nucleus of mammalian cells, focusing in particular on how chromatin is radially arranged with respect to the nuclear lamina. We then discuss the possible mechanisms by which the radial organization of chromatin in the cell nucleus is established. Lastly, we propose a unifying model of nuclear spatial organization, and suggest novel approaches to test it. |
| first_indexed | 2024-12-13T18:47:28Z |
| format | Article |
| id | doaj.art-b83c20a064cd45128039487ce5509371 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-13T18:47:28Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-b83c20a064cd45128039487ce55093712022-12-21T23:35:02ZengFrontiers Media S.A.Frontiers in Genetics1664-80212020-02-011110.3389/fgene.2020.00033504194Radial Organization in the Mammalian NucleusNicola CrosettoMagda BienkoIn eukaryotic cells, most of the genetic material is contained within a highly specialized organelle—the nucleus. A large body of evidence indicates that, within the nucleus, chromatinized DNA is spatially organized at multiple length scales. The higher-order organization of chromatin is crucial for proper execution of multiple genome functions, including DNA replication and transcription. Here, we review our current knowledge on the spatial organization of chromatin in the nucleus of mammalian cells, focusing in particular on how chromatin is radially arranged with respect to the nuclear lamina. We then discuss the possible mechanisms by which the radial organization of chromatin in the cell nucleus is established. Lastly, we propose a unifying model of nuclear spatial organization, and suggest novel approaches to test it.https://www.frontiersin.org/article/10.3389/fgene.2020.00033/full3D chromatin architecturegene expression regulationnucleusgenome organizationchromosoma |
| spellingShingle | Nicola Crosetto Magda Bienko Radial Organization in the Mammalian Nucleus Frontiers in Genetics 3D chromatin architecture gene expression regulation nucleus genome organization chromosoma |
| title | Radial Organization in the Mammalian Nucleus |
| title_full | Radial Organization in the Mammalian Nucleus |
| title_fullStr | Radial Organization in the Mammalian Nucleus |
| title_full_unstemmed | Radial Organization in the Mammalian Nucleus |
| title_short | Radial Organization in the Mammalian Nucleus |
| title_sort | radial organization in the mammalian nucleus |
| topic | 3D chromatin architecture gene expression regulation nucleus genome organization chromosoma |
| url | https://www.frontiersin.org/article/10.3389/fgene.2020.00033/full |
| work_keys_str_mv | AT nicolacrosetto radialorganizationinthemammaliannucleus AT magdabienko radialorganizationinthemammaliannucleus |