Joint analysis of PK and immunogenicity outcomes using factorization model − a powerful approach for PK similarity study

Joint analysis of PK and immunogenicity outcomes using factorization model − a powerful approach for PK similarity study

Abstract Biological products, whether they are innovator products or biosimilars, can incite an immunogenic response ensuing in the development of anti-drug antibodies (ADA). The presence of ADA’s often affects the drug clearance, resulting in an increase in the variability of pharmacokinetic (PK) a...

সম্পূর্ণ বিবরণ

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Halimu N. Haliduola, Fausto Berti, Heimo Stroissnig, Eric Guenzi, Hendrik Otto, Abid Sattar, Ulrich Mansmann
বিন্যাস: প্রবন্ধ
ভাষা:English
প্রকাশিত: BMC 2022-10-01
মালা:BMC Medical Research Methodology
বিষয়গুলি:
Biosimilars
PK similarity
Immunogenicity
Factorization model
Bioequivalence
অনলাইন ব্যবহার করুন:https://doi.org/10.1186/s12874-022-01742-2

আন্তর্জাল

https://doi.org/10.1186/s12874-022-01742-2

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