Nuclear overexpression of metastasis-associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinoma
<p>Abstract</p> <p>Background</p> <p>Metastasis-associated protein 1 (MTA1) has been associated with poor prognosis in several malignant carcinomas. The purpose of this study was to investigate the expression and prognostic value of MTA1 in nasopharyngeal carcinoma (NPC...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-04-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | http://www.translational-medicine.com/content/10/1/78 |
| _version_ | 1818936304967090176 |
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| author | Li Wen-Fei Liu Na Cui Rui-Xue He Qing-Mei Chen Mo Jiang Ning Sun Ying Zeng Jing Liu Li-Zhi Ma Jun |
| author_facet | Li Wen-Fei Liu Na Cui Rui-Xue He Qing-Mei Chen Mo Jiang Ning Sun Ying Zeng Jing Liu Li-Zhi Ma Jun |
| author_sort | Li Wen-Fei |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Metastasis-associated protein 1 (MTA1) has been associated with poor prognosis in several malignant carcinomas. The purpose of this study was to investigate the expression and prognostic value of MTA1 in nasopharyngeal carcinoma (NPC).</p> <p>Methods</p> <p>MTA1 expression was assessed using immunohistochemistry in paraffin-embedded tumor specimens from 208 untreated NPC patients. Cox regression analysis was used to calculate the hazard ratio (HR), 95% confidence interval (CI) and identify independent prognostic factors, and recursive partitioning analysis was used to create a decision tree.</p> <p>Results</p> <p>Nuclear overexpression of MTA1 was observed in 48.6% (101/208) of the NPC tissues. Nuclear overexpression of MTA1 correlated positively with N classification (<it>P</it> = 0.02), clinical stage (<it>P</it> = 0.04), distant metastasis (<it>P</it> < 0.01) and death (<it>P</it> = 0.01). Additionally, nuclear overexpression of MTA1 correlated significantly with poorer distant metastasis-free survival (DMFS; <it>P</it> <0.01) and poorer overall survival (OS; <it>P</it> < 0.01). MTA1 had prognostic significance in NPC patients with stage II disease, but not stage III or IV disease. Multivariate analysis demonstrated that nuclear overexpression of MTA1 was independently associated with poorer DMFS (HR, 2.05; 95% CI, 1.13–3.72; <it>P</it> = 0.02) and poorer OS (HR, 1.98; 95% CI, 1.09–3.59; <it>P</it> = 0.03). Using recursive partitioning analysis, the NPC patients could be classified with a low, intermediate or high risk of distant metastasis and death, on the basis of clinical stage, age and MTA1 expression.</p> <p>Conclusion</p> <p>The results of this study suggest that nuclear overexpression of MTA1 correlates significantly with poorer DMFS and poorer OS in NPC. MTA1 has potential as a novel prognostic biomarker in NPC.</p> |
| first_indexed | 2024-12-20T05:33:57Z |
| format | Article |
| id | doaj.art-b83e75169c394994b709ad60a1f59103 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-20T05:33:57Z |
| publishDate | 2012-04-01 |
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| series | Journal of Translational Medicine |
| spelling | doaj.art-b83e75169c394994b709ad60a1f591032022-12-21T19:51:41ZengBMCJournal of Translational Medicine1479-58762012-04-011017810.1186/1479-5876-10-78Nuclear overexpression of metastasis-associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinomaLi Wen-FeiLiu NaCui Rui-XueHe Qing-MeiChen MoJiang NingSun YingZeng JingLiu Li-ZhiMa Jun<p>Abstract</p> <p>Background</p> <p>Metastasis-associated protein 1 (MTA1) has been associated with poor prognosis in several malignant carcinomas. The purpose of this study was to investigate the expression and prognostic value of MTA1 in nasopharyngeal carcinoma (NPC).</p> <p>Methods</p> <p>MTA1 expression was assessed using immunohistochemistry in paraffin-embedded tumor specimens from 208 untreated NPC patients. Cox regression analysis was used to calculate the hazard ratio (HR), 95% confidence interval (CI) and identify independent prognostic factors, and recursive partitioning analysis was used to create a decision tree.</p> <p>Results</p> <p>Nuclear overexpression of MTA1 was observed in 48.6% (101/208) of the NPC tissues. Nuclear overexpression of MTA1 correlated positively with N classification (<it>P</it> = 0.02), clinical stage (<it>P</it> = 0.04), distant metastasis (<it>P</it> < 0.01) and death (<it>P</it> = 0.01). Additionally, nuclear overexpression of MTA1 correlated significantly with poorer distant metastasis-free survival (DMFS; <it>P</it> <0.01) and poorer overall survival (OS; <it>P</it> < 0.01). MTA1 had prognostic significance in NPC patients with stage II disease, but not stage III or IV disease. Multivariate analysis demonstrated that nuclear overexpression of MTA1 was independently associated with poorer DMFS (HR, 2.05; 95% CI, 1.13–3.72; <it>P</it> = 0.02) and poorer OS (HR, 1.98; 95% CI, 1.09–3.59; <it>P</it> = 0.03). Using recursive partitioning analysis, the NPC patients could be classified with a low, intermediate or high risk of distant metastasis and death, on the basis of clinical stage, age and MTA1 expression.</p> <p>Conclusion</p> <p>The results of this study suggest that nuclear overexpression of MTA1 correlates significantly with poorer DMFS and poorer OS in NPC. MTA1 has potential as a novel prognostic biomarker in NPC.</p>http://www.translational-medicine.com/content/10/1/78Nasopharyngeal carcinomaBiomarkerMTA1Prognosis |
| spellingShingle | Li Wen-Fei Liu Na Cui Rui-Xue He Qing-Mei Chen Mo Jiang Ning Sun Ying Zeng Jing Liu Li-Zhi Ma Jun Nuclear overexpression of metastasis-associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinoma Journal of Translational Medicine Nasopharyngeal carcinoma Biomarker MTA1 Prognosis |
| title | Nuclear overexpression of metastasis-associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinoma |
| title_full | Nuclear overexpression of metastasis-associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinoma |
| title_fullStr | Nuclear overexpression of metastasis-associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinoma |
| title_full_unstemmed | Nuclear overexpression of metastasis-associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinoma |
| title_short | Nuclear overexpression of metastasis-associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinoma |
| title_sort | nuclear overexpression of metastasis associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinoma |
| topic | Nasopharyngeal carcinoma Biomarker MTA1 Prognosis |
| url | http://www.translational-medicine.com/content/10/1/78 |
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