Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal study
<p>Abstract</p> <p>Background</p> <p>Human papillomaviruses are the most common sexually transmitted infections, and genital warts, caused by HPV-6 and 11, entail considerable morbidity and cost. The natural history of genital warts in relation to HIV-1 infection has no...
| Главные авторы: | , , , , , , , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
BMC
2011-01-01
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| Серии: | BMC Infectious Diseases |
| Online-ссылка: | http://www.biomedcentral.com/1471-2334/11/20 |
| _version_ | 1828772448873480192 |
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| author | Van de Perre Philippe Segondy Michel Ouedraogo Abdoulaye Huet Charlotte Didelot-Rousseau Marie-Noelle Nagot Nicolas Konate Issouf Clayton Tim Low Andrea J Mayaud Philippe |
| author_facet | Van de Perre Philippe Segondy Michel Ouedraogo Abdoulaye Huet Charlotte Didelot-Rousseau Marie-Noelle Nagot Nicolas Konate Issouf Clayton Tim Low Andrea J Mayaud Philippe |
| author_sort | Van de Perre Philippe |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Human papillomaviruses are the most common sexually transmitted infections, and genital warts, caused by HPV-6 and 11, entail considerable morbidity and cost. The natural history of genital warts in relation to HIV-1 infection has not been described in African women. We examined risk factors for genital warts in a cohort of high-risk women in Burkina Faso, in order to further describe their epidemiology.</p> <p>Methods</p> <p>A prospective study of 765 high-risk women who were followed at 4-monthly intervals for 27 months in Burkina Faso. Logistic and Cox regression were used to identify factors associated with prevalent, incident and persistent genital warts, including HIV-1 serostatus, CD4+ count, and concurrent sexually transmitted infections. In a subset of 306 women, cervical HPV DNA was tested at enrolment.</p> <p>Results</p> <p>Genital wart prevalence at baseline was 1.6% (8/492) among HIV-uninfected and 7.0% (19/273) among HIV-1 seropositive women. Forty women (5.2%) experienced at least one incident GW episode. Incidence was 1.1 per 100 person-years among HIV-uninfected women, 7.4 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count >200 cells/μL and 14.6 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count ≤200 cells/μL. Incident genital warts were also associated with concurrent bacterial vaginosis, and genital ulceration. Antiretroviral therapy was not protective against incident or persistent genital warts. Detection of HPV-6 DNA and abnormal cervical cytology were strongly associated with incident genital warts.</p> <p>Conclusions</p> <p>Genital warts occur much more frequently among HIV-1 infected women in Africa, particularly among those with low CD4+ counts. Antiretroviral therapy did not reduce the incidence or persistence of genital warts in this population.</p> |
| first_indexed | 2024-12-11T14:44:03Z |
| format | Article |
| id | doaj.art-b83fa9d4b7af4c5a85eab34cd84f5de1 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-11T14:44:03Z |
| publishDate | 2011-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-b83fa9d4b7af4c5a85eab34cd84f5de12022-12-22T01:01:46ZengBMCBMC Infectious Diseases1471-23342011-01-011112010.1186/1471-2334-11-20Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal studyVan de Perre PhilippeSegondy MichelOuedraogo AbdoulayeHuet CharlotteDidelot-Rousseau Marie-NoelleNagot NicolasKonate IssoufClayton TimLow Andrea JMayaud Philippe<p>Abstract</p> <p>Background</p> <p>Human papillomaviruses are the most common sexually transmitted infections, and genital warts, caused by HPV-6 and 11, entail considerable morbidity and cost. The natural history of genital warts in relation to HIV-1 infection has not been described in African women. We examined risk factors for genital warts in a cohort of high-risk women in Burkina Faso, in order to further describe their epidemiology.</p> <p>Methods</p> <p>A prospective study of 765 high-risk women who were followed at 4-monthly intervals for 27 months in Burkina Faso. Logistic and Cox regression were used to identify factors associated with prevalent, incident and persistent genital warts, including HIV-1 serostatus, CD4+ count, and concurrent sexually transmitted infections. In a subset of 306 women, cervical HPV DNA was tested at enrolment.</p> <p>Results</p> <p>Genital wart prevalence at baseline was 1.6% (8/492) among HIV-uninfected and 7.0% (19/273) among HIV-1 seropositive women. Forty women (5.2%) experienced at least one incident GW episode. Incidence was 1.1 per 100 person-years among HIV-uninfected women, 7.4 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count >200 cells/μL and 14.6 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count ≤200 cells/μL. Incident genital warts were also associated with concurrent bacterial vaginosis, and genital ulceration. Antiretroviral therapy was not protective against incident or persistent genital warts. Detection of HPV-6 DNA and abnormal cervical cytology were strongly associated with incident genital warts.</p> <p>Conclusions</p> <p>Genital warts occur much more frequently among HIV-1 infected women in Africa, particularly among those with low CD4+ counts. Antiretroviral therapy did not reduce the incidence or persistence of genital warts in this population.</p>http://www.biomedcentral.com/1471-2334/11/20 |
| spellingShingle | Van de Perre Philippe Segondy Michel Ouedraogo Abdoulaye Huet Charlotte Didelot-Rousseau Marie-Noelle Nagot Nicolas Konate Issouf Clayton Tim Low Andrea J Mayaud Philippe Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal study BMC Infectious Diseases |
| title | Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal study |
| title_full | Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal study |
| title_fullStr | Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal study |
| title_full_unstemmed | Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal study |
| title_short | Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso: a longitudinal study |
| title_sort | genital warts and infection with human immunodeficiency virus in high risk women in burkina faso a longitudinal study |
| url | http://www.biomedcentral.com/1471-2334/11/20 |
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