Adipose derived stem cells in radiotherapy injury: a new frontier
Radiotherapy is increasingly used to treat numerous human malignancies. In addition to the beneficial anti-cancer effects, there are a series of undesirable effects on normal host tissues surrounding the target tumour. Whilst the early effects of radiotherapy (desquamation, erythema and hair loss) t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-01-01
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| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fsurg.2015.00001/full |
| _version_ | 1828870016130351104 |
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| author | Lipi eShukla Lipi eShukla Lipi eShukla Wayne eMorrison Wayne eMorrison Wayne eMorrison Ramin eShayan Ramin eShayan Ramin eShayan |
| author_facet | Lipi eShukla Lipi eShukla Lipi eShukla Wayne eMorrison Wayne eMorrison Wayne eMorrison Ramin eShayan Ramin eShayan Ramin eShayan |
| author_sort | Lipi eShukla |
| collection | DOAJ |
| description | Radiotherapy is increasingly used to treat numerous human malignancies. In addition to the beneficial anti-cancer effects, there are a series of undesirable effects on normal host tissues surrounding the target tumour. Whilst the early effects of radiotherapy (desquamation, erythema and hair loss) typically resolve, the chronic effects persist as unpredictable and often troublesome sequelae of cancer treatment, long after oncological treatment has been completed. Plastic surgeons are often called upon to treat the problems subsequently arising in irradiated tissues, such as recurrent infection, impaired healing, fibrosis, contracture and/or lymphoedema. Recently, it was anecdotally noted - then validated in more robust animal and human studies - that fat grafting can ameliorate some of these chronic tissue effects. Despite the widespread usage of fat grafting, the mechanism of its action remains poorly understood. This review provides an overview of the current understanding of (i) mechanisms of chronic radiation injury and its clinical manifestations; (ii) biological properties of fat grafts and their key constituent, Adipose-Derived Stem Cells (ADSCs); (iii) the role of ADSCs in radiotherapy-induced soft-tissue injury. |
| first_indexed | 2024-12-13T06:02:36Z |
| format | Article |
| id | doaj.art-b8406fd73dae445e9c38e0aa32317374 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-12-13T06:02:36Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-b8406fd73dae445e9c38e0aa323173742022-12-21T23:57:18ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2015-01-01210.3389/fsurg.2015.00001123490Adipose derived stem cells in radiotherapy injury: a new frontierLipi eShukla0Lipi eShukla1Lipi eShukla2Wayne eMorrison3Wayne eMorrison4Wayne eMorrison5Ramin eShayan6Ramin eShayan7Ramin eShayan8O'Brien InstituteSt Vincent's HospitalAustralian Catholic UniversityO'Brien InstituteSt Vincent's HospitalAustralian Catholic UniversityO'Brien InstituteSt Vincent's HospitalAustralian Catholic UniversityRadiotherapy is increasingly used to treat numerous human malignancies. In addition to the beneficial anti-cancer effects, there are a series of undesirable effects on normal host tissues surrounding the target tumour. Whilst the early effects of radiotherapy (desquamation, erythema and hair loss) typically resolve, the chronic effects persist as unpredictable and often troublesome sequelae of cancer treatment, long after oncological treatment has been completed. Plastic surgeons are often called upon to treat the problems subsequently arising in irradiated tissues, such as recurrent infection, impaired healing, fibrosis, contracture and/or lymphoedema. Recently, it was anecdotally noted - then validated in more robust animal and human studies - that fat grafting can ameliorate some of these chronic tissue effects. Despite the widespread usage of fat grafting, the mechanism of its action remains poorly understood. This review provides an overview of the current understanding of (i) mechanisms of chronic radiation injury and its clinical manifestations; (ii) biological properties of fat grafts and their key constituent, Adipose-Derived Stem Cells (ADSCs); (iii) the role of ADSCs in radiotherapy-induced soft-tissue injury.http://journal.frontiersin.org/Journal/10.3389/fsurg.2015.00001/fullRadiationRadiotherapyCancerAdipose derived Stem Cellsfat injectionAutologous fat grafting |
| spellingShingle | Lipi eShukla Lipi eShukla Lipi eShukla Wayne eMorrison Wayne eMorrison Wayne eMorrison Ramin eShayan Ramin eShayan Ramin eShayan Adipose derived stem cells in radiotherapy injury: a new frontier Frontiers in Surgery Radiation Radiotherapy Cancer Adipose derived Stem Cells fat injection Autologous fat grafting |
| title | Adipose derived stem cells in radiotherapy injury: a new frontier |
| title_full | Adipose derived stem cells in radiotherapy injury: a new frontier |
| title_fullStr | Adipose derived stem cells in radiotherapy injury: a new frontier |
| title_full_unstemmed | Adipose derived stem cells in radiotherapy injury: a new frontier |
| title_short | Adipose derived stem cells in radiotherapy injury: a new frontier |
| title_sort | adipose derived stem cells in radiotherapy injury a new frontier |
| topic | Radiation Radiotherapy Cancer Adipose derived Stem Cells fat injection Autologous fat grafting |
| url | http://journal.frontiersin.org/Journal/10.3389/fsurg.2015.00001/full |
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