The predictive value of CD4, CD8, and C—reactive protein in the prognosis of schistosomal and non-schistosomal colorectal cancer
Abstract Background Although schistosomiasis has been basically eliminated, it has not been completely extinction in China and occasional outbreaks occur in Europe in recent years. The relationship between inflammation caused by Schistosoma japonicum and colorectal cancer (CRC) is still obscure, and...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-023-02834-z |
| _version_ | 1797806732984975360 |
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| author | Meihong Cheng Hongyan Jing Dacheng Bu Jing Liu Kui Lu Jican Liu Yanchao Xu Ting Zhu Yingyong Hou Junxia Yao Qilin Zhai Weixia Wang |
| author_facet | Meihong Cheng Hongyan Jing Dacheng Bu Jing Liu Kui Lu Jican Liu Yanchao Xu Ting Zhu Yingyong Hou Junxia Yao Qilin Zhai Weixia Wang |
| author_sort | Meihong Cheng |
| collection | DOAJ |
| description | Abstract Background Although schistosomiasis has been basically eliminated, it has not been completely extinction in China and occasional outbreaks occur in Europe in recent years. The relationship between inflammation caused by Schistosoma japonicum and colorectal cancer (CRC) is still obscure, and the inflammation based prognostic systems of schistosomal colorectal (SCRC) has rarely been reported. Aim To explore the different roles of tumor infiltrating lymphocytes (TILs) and C-reactive protein (CRP) in SCRC and in Non-schistosomal CRC (NSCRC), providing a possible predictive system to evaluate outcomes and to improve the risk stratification for CRC patients, especially for CRC patients with schistosomiasis. Methods Three hundred fifty-one CRC tumors were evaluated for density of CD4 + , CD8 + T cells and CRP in intratumoral and stromal compartments by immunohistochemical using tissue microarray. Results There were no association between TILs and CRP and schistosomiasis. Multivariate analysis identified stromal CD4 (sCD4) (p = 0.038), intratumoral CD8 (iCD8) (p = 0.003), schistosomiasis (p = 0.045) as independent prognostic factors for overall survival (OS) in the whole cohort; and sCD4 (p = 0.006) and iCD8 (p = 0.020) were independent prognostic factors for OS in the NSCRC and SCRC set, respectively. Besides, we found that there were no differences of TILs and CRP, which were distributed in different areas of tumor tissue, between CRC patients with and without schistosomiasis. Conclusion The results remind us that different subtypes of TILs have distinguished biological behavior and prognosis value in the immune microenvironment of NSCRC and SCRC patients. Meanwhile, the findings require us to stratify patients with schistosomiasis and this might facilitate patient counseling and management. |
| first_indexed | 2024-03-13T06:11:46Z |
| format | Article |
| id | doaj.art-b840cede0c454bb6858ee50f7a0d8b7c |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-13T06:11:46Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-b840cede0c454bb6858ee50f7a0d8b7c2023-06-11T11:15:49ZengBMCBMC Gastroenterology1471-230X2023-06-0123111210.1186/s12876-023-02834-zThe predictive value of CD4, CD8, and C—reactive protein in the prognosis of schistosomal and non-schistosomal colorectal cancerMeihong Cheng0Hongyan Jing1Dacheng Bu2Jing Liu3Kui Lu4Jican Liu5Yanchao Xu6Ting Zhu7Yingyong Hou8Junxia Yao9Qilin Zhai10Weixia Wang11Qingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityQingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityQingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityQingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityQingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityQingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityQingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityQingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityDepartment of Pathology, Zhongshan Hospital, Fudan UniversityQingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityQingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityQingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityAbstract Background Although schistosomiasis has been basically eliminated, it has not been completely extinction in China and occasional outbreaks occur in Europe in recent years. The relationship between inflammation caused by Schistosoma japonicum and colorectal cancer (CRC) is still obscure, and the inflammation based prognostic systems of schistosomal colorectal (SCRC) has rarely been reported. Aim To explore the different roles of tumor infiltrating lymphocytes (TILs) and C-reactive protein (CRP) in SCRC and in Non-schistosomal CRC (NSCRC), providing a possible predictive system to evaluate outcomes and to improve the risk stratification for CRC patients, especially for CRC patients with schistosomiasis. Methods Three hundred fifty-one CRC tumors were evaluated for density of CD4 + , CD8 + T cells and CRP in intratumoral and stromal compartments by immunohistochemical using tissue microarray. Results There were no association between TILs and CRP and schistosomiasis. Multivariate analysis identified stromal CD4 (sCD4) (p = 0.038), intratumoral CD8 (iCD8) (p = 0.003), schistosomiasis (p = 0.045) as independent prognostic factors for overall survival (OS) in the whole cohort; and sCD4 (p = 0.006) and iCD8 (p = 0.020) were independent prognostic factors for OS in the NSCRC and SCRC set, respectively. Besides, we found that there were no differences of TILs and CRP, which were distributed in different areas of tumor tissue, between CRC patients with and without schistosomiasis. Conclusion The results remind us that different subtypes of TILs have distinguished biological behavior and prognosis value in the immune microenvironment of NSCRC and SCRC patients. Meanwhile, the findings require us to stratify patients with schistosomiasis and this might facilitate patient counseling and management.https://doi.org/10.1186/s12876-023-02834-zCD4 + T cellCD8 + T cellC-reactive proteinSchistosomiasisColorectal cancerPrognosis |
| spellingShingle | Meihong Cheng Hongyan Jing Dacheng Bu Jing Liu Kui Lu Jican Liu Yanchao Xu Ting Zhu Yingyong Hou Junxia Yao Qilin Zhai Weixia Wang The predictive value of CD4, CD8, and C—reactive protein in the prognosis of schistosomal and non-schistosomal colorectal cancer BMC Gastroenterology CD4 + T cell CD8 + T cell C-reactive protein Schistosomiasis Colorectal cancer Prognosis |
| title | The predictive value of CD4, CD8, and C—reactive protein in the prognosis of schistosomal and non-schistosomal colorectal cancer |
| title_full | The predictive value of CD4, CD8, and C—reactive protein in the prognosis of schistosomal and non-schistosomal colorectal cancer |
| title_fullStr | The predictive value of CD4, CD8, and C—reactive protein in the prognosis of schistosomal and non-schistosomal colorectal cancer |
| title_full_unstemmed | The predictive value of CD4, CD8, and C—reactive protein in the prognosis of schistosomal and non-schistosomal colorectal cancer |
| title_short | The predictive value of CD4, CD8, and C—reactive protein in the prognosis of schistosomal and non-schistosomal colorectal cancer |
| title_sort | predictive value of cd4 cd8 and c reactive protein in the prognosis of schistosomal and non schistosomal colorectal cancer |
| topic | CD4 + T cell CD8 + T cell C-reactive protein Schistosomiasis Colorectal cancer Prognosis |
| url | https://doi.org/10.1186/s12876-023-02834-z |
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