Comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothers
Background: Gestational diabetes is associated with increased risk of congenital heart disease in neonates. The study was performed to evaluate the cardiac parameters in neonates of mothers with abnormal glucose tolerance test (GTT) and compare them with data of normal newborn. Methods: In a cross-s...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Tehran University of Medical Sciences
2014-11-01
|
| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5266&slc_lang=en&sid=1 |
| _version_ | 1819140276132773888 |
|---|---|
| author | Semira Mehralizadeh Majid Mirmohammadkhani Maryam Naderi Eram Shamsollah Noripour |
| author_facet | Semira Mehralizadeh Majid Mirmohammadkhani Maryam Naderi Eram Shamsollah Noripour |
| author_sort | Semira Mehralizadeh |
| collection | DOAJ |
| description | Background: Gestational diabetes is associated with increased risk of congenital heart disease in neonates. The study was performed to evaluate the cardiac parameters in neonates of mothers with abnormal glucose tolerance test (GTT) and compare them with data of normal newborn.
Methods: In a cross-sectional study in Amiralmomenin Hospital, Semnan City, Iran from April to October 2013, two groups of infants were eligible for the study. Sampling was performed in succession for the infants who were eligible. Echocardiography was performed for the babies on the second day, and cardiac parameters including interventricular septal diameter, left ventricular shortening fraction and mass, left ventricular posterior wall thickness, aortic and left atrial diameter were measured. Maternal glycemic control and HbA1c were measured indicators. Analysis with the SPSS software version 16, the Student’s t-test, Mann-Whitney and Chi-square test were performed.
Results: Thirty five newborn infants of mothers with impaired GTT and newborn of 33 healthy women were studied. Birth weight, maternal age and HbA1c among infants of mothers with impaired GTT were greater than the control group (P=0.003 and P=0.000 and P=0.000 respectively). Diastolic and systolic ventricular septal thickness, ratio of diastolic ventricular septal thickness to diastolic diameter of the left ventricular posterior wall, the aortic diameter and left ventricular outflow tract diameter in infants of mothers with impaired GTT were significantly increased in comparison to data of the normal group (P=0.008, P=0.034, P=0.016, P=0.017 and P=0.020 respectively). No significant difference was reported in other diameters.
Conclusion: Gestational diabetes mellitus results in changes of echocardiographic findings particularly relevant in diastolic ventricular septal thickness. The increase in wall thickness especially during diastole, is associated with pathological cardiac hypertrophy. Based on the results of the present study, cardiac hypertrophy can be related to gestational diabetes. Poor control of disease may cause or aggravate the process. |
| first_indexed | 2024-12-22T11:35:59Z |
| format | Article |
| id | doaj.art-b84232ee4eb24eaabe78210cad18cbda |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-22T11:35:59Z |
| publishDate | 2014-11-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-b84232ee4eb24eaabe78210cad18cbda2022-12-21T18:27:26ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222014-11-01728555563Comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothersSemira Mehralizadeh 0Majid Mirmohammadkhani 1Maryam Naderi Eram 2Shamsollah Noripour 3 Department of Cardiology, Semnan University of Medical Sciences, Amir Hospital, Semnan, Iran. Research Center of Social Determinants of Health, Epidemiologist, Medical School, Semnan University of Medical Sciences, Semnan, Iran. Department of Pediatrics, Semnan University of Medical Sciences, Amir Hospital, Semnan, Iran. Department of Neonatology, Semnan University of Medical Sciences, Amir Hospital, Semnan, Iran. Background: Gestational diabetes is associated with increased risk of congenital heart disease in neonates. The study was performed to evaluate the cardiac parameters in neonates of mothers with abnormal glucose tolerance test (GTT) and compare them with data of normal newborn. Methods: In a cross-sectional study in Amiralmomenin Hospital, Semnan City, Iran from April to October 2013, two groups of infants were eligible for the study. Sampling was performed in succession for the infants who were eligible. Echocardiography was performed for the babies on the second day, and cardiac parameters including interventricular septal diameter, left ventricular shortening fraction and mass, left ventricular posterior wall thickness, aortic and left atrial diameter were measured. Maternal glycemic control and HbA1c were measured indicators. Analysis with the SPSS software version 16, the Student’s t-test, Mann-Whitney and Chi-square test were performed. Results: Thirty five newborn infants of mothers with impaired GTT and newborn of 33 healthy women were studied. Birth weight, maternal age and HbA1c among infants of mothers with impaired GTT were greater than the control group (P=0.003 and P=0.000 and P=0.000 respectively). Diastolic and systolic ventricular septal thickness, ratio of diastolic ventricular septal thickness to diastolic diameter of the left ventricular posterior wall, the aortic diameter and left ventricular outflow tract diameter in infants of mothers with impaired GTT were significantly increased in comparison to data of the normal group (P=0.008, P=0.034, P=0.016, P=0.017 and P=0.020 respectively). No significant difference was reported in other diameters. Conclusion: Gestational diabetes mellitus results in changes of echocardiographic findings particularly relevant in diastolic ventricular septal thickness. The increase in wall thickness especially during diastole, is associated with pathological cardiac hypertrophy. Based on the results of the present study, cardiac hypertrophy can be related to gestational diabetes. Poor control of disease may cause or aggravate the process.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5266&slc_lang=en&sid=1echocardiography gestational diabetes hemoglobin A |
| spellingShingle | Semira Mehralizadeh Majid Mirmohammadkhani Maryam Naderi Eram Shamsollah Noripour Comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothers Tehran University Medical Journal echocardiography gestational diabetes hemoglobin A |
| title | Comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothers |
| title_full | Comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothers |
| title_fullStr | Comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothers |
| title_full_unstemmed | Comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothers |
| title_short | Comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothers |
| title_sort | comparison of echocardiographic findings in infants of mothers with gestational diabetes and healthy mothers |
| topic | echocardiography gestational diabetes hemoglobin A |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5266&slc_lang=en&sid=1 |
| work_keys_str_mv | AT semiramehralizadeh comparisonofechocardiographicfindingsininfantsofmotherswithgestationaldiabetesandhealthymothers AT majidmirmohammadkhani comparisonofechocardiographicfindingsininfantsofmotherswithgestationaldiabetesandhealthymothers AT maryamnaderieram comparisonofechocardiographicfindingsininfantsofmotherswithgestationaldiabetesandhealthymothers AT shamsollahnoripour comparisonofechocardiographicfindingsininfantsofmotherswithgestationaldiabetesandhealthymothers |