Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics
Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/10/5/875 |
| _version_ | 1797569068320948224 |
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| author | Giulia Chindamo Simona Sapino Elena Peira Daniela Chirio Mónica Cristina Gonzalez Marina Gallarate |
| author_facet | Giulia Chindamo Simona Sapino Elena Peira Daniela Chirio Mónica Cristina Gonzalez Marina Gallarate |
| author_sort | Giulia Chindamo |
| collection | DOAJ |
| description | Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration. |
| first_indexed | 2024-03-10T20:06:48Z |
| format | Article |
| id | doaj.art-b84246e05d7243a69257876e72321b59 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T20:06:48Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-b84246e05d7243a69257876e72321b592023-11-19T23:15:59ZengMDPI AGNanomaterials2079-49912020-05-0110587510.3390/nano10050875Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted TherapeuticsGiulia Chindamo0Simona Sapino1Elena Peira2Daniela Chirio3Mónica Cristina Gonzalez4Marina Gallarate5Department of Drug Science and Technology, University of Turin, 10125 Turin, ItalyDepartment of Drug Science and Technology, University of Turin, 10125 Turin, ItalyDepartment of Drug Science and Technology, University of Turin, 10125 Turin, ItalyDepartment of Drug Science and Technology, University of Turin, 10125 Turin, ItalyInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata 1900, ArgentinaDepartment of Drug Science and Technology, University of Turin, 10125 Turin, ItalyBone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration.https://www.mdpi.com/2079-4991/10/5/875bone diseasesbone regenerationnanotechnologytargeted delivery systemscalcium phosphate |
| spellingShingle | Giulia Chindamo Simona Sapino Elena Peira Daniela Chirio Mónica Cristina Gonzalez Marina Gallarate Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics Nanomaterials bone diseases bone regeneration nanotechnology targeted delivery systems calcium phosphate |
| title | Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics |
| title_full | Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics |
| title_fullStr | Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics |
| title_full_unstemmed | Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics |
| title_short | Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics |
| title_sort | bone diseases current approach and future perspectives in drug delivery systems for bone targeted therapeutics |
| topic | bone diseases bone regeneration nanotechnology targeted delivery systems calcium phosphate |
| url | https://www.mdpi.com/2079-4991/10/5/875 |
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