Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated Syndrome
Background and purpose: Whether some gray matter (GM) regions are differentially vulnerable at the early stages of MS is still unknown. The objective of this study is to investigate whether deep and cortical GM are differentially vulnerable after a clinically isolated syndrome (CIS) suggestive of mu...
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| Format: | Article |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00824/full |
| _version_ | 1819208137932013568 |
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| author | Ismail Koubiyr Ismail Koubiyr Mathilde Deloire Pierrick Coupé Cécile Dulau Pierre Besson Amandine Moroso Amandine Moroso Vincent Planche Vincent Planche Vincent Planche Thomas Tourdias Thomas Tourdias Thomas Tourdias Bruno Brochet Bruno Brochet Bruno Brochet Aurélie Ruet Aurélie Ruet Aurélie Ruet |
| author_facet | Ismail Koubiyr Ismail Koubiyr Mathilde Deloire Pierrick Coupé Cécile Dulau Pierre Besson Amandine Moroso Amandine Moroso Vincent Planche Vincent Planche Vincent Planche Thomas Tourdias Thomas Tourdias Thomas Tourdias Bruno Brochet Bruno Brochet Bruno Brochet Aurélie Ruet Aurélie Ruet Aurélie Ruet |
| author_sort | Ismail Koubiyr |
| collection | DOAJ |
| description | Background and purpose: Whether some gray matter (GM) regions are differentially vulnerable at the early stages of MS is still unknown. The objective of this study is to investigate whether deep and cortical GM are differentially vulnerable after a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS).Methods: Fifty-six patients with CIS (PwCIS) and 38 healthy controls (HC) had conventional and diffusion tensor imaging (DTI) at baseline and 46 PwCIS and 20 HC were rescanned after 1 year. Deep GM (DGM) volumes, cortical thickness (CTh), and DTI metrics (FA: fractional anisotropy; MD: mean diffusivity) within these structures were calculated for each participant at each time-point and compared between PwCIS and HC. Linear regression models were used to investigate whether baseline DTI parameters could predict GM volume loss over time.Results: At baseline, GM volumes did not differ between PwCIS and HC, but hippocampal MD was higher in PwCIS than HC (p < 0.01). Over 1 year, GM alterations became more widespread with putamen and hippocampus volumes decreasing in PwCIS (p < 0.01), and cortical thinning in different parts of the cortex along with a significant increase of MD. Hippocampus MD at baseline could predict its volume loss (R2 = 0.159; p < 0.05) and cortical thinning was associated to microstructural damage (Spearman's rho ranging from −0.424 to −0.603 with p < 0.003).Conclusion: Along with MS being a diffuse inflammatory disease, GM showed a differential vulnerability at the early stage spreading from hippocampus to the cortex. Hippocampus volume loss could be predicted by its MD at baseline. |
| first_indexed | 2024-12-23T05:34:37Z |
| format | Article |
| id | doaj.art-b842cae0957c428e947be288ae2c7610 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-23T05:34:37Z |
| publishDate | 2018-10-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-b842cae0957c428e947be288ae2c76102022-12-21T17:58:23ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-10-01910.3389/fneur.2018.00824415429Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated SyndromeIsmail Koubiyr0Ismail Koubiyr1Mathilde Deloire2Pierrick Coupé3Cécile Dulau4Pierre Besson5Amandine Moroso6Amandine Moroso7Vincent Planche8Vincent Planche9Vincent Planche10Thomas Tourdias11Thomas Tourdias12Thomas Tourdias13Bruno Brochet14Bruno Brochet15Bruno Brochet16Aurélie Ruet17Aurélie Ruet18Aurélie Ruet19Univ. Bordeaux, Bordeaux, FranceInserm U1215 - Neurocentre Magendie, Bordeaux, FranceCHU de Bordeaux, Bordeaux, FranceLaboratoire Bordelais de Recherche en Informatique, UMR CNRS 5800, PICTURA, Talence, FranceCHU de Bordeaux, Bordeaux, FranceAixMarseille Univ, CNRS, CRMBM UMR 7339, Marseille, FranceUniv. Bordeaux, Bordeaux, FranceCHU de Bordeaux, Bordeaux, FranceUniv. Bordeaux, Bordeaux, FranceInserm U1215 - Neurocentre Magendie, Bordeaux, FranceCHU de Bordeaux, Bordeaux, FranceUniv. Bordeaux, Bordeaux, FranceInserm U1215 - Neurocentre Magendie, Bordeaux, FranceCHU de Bordeaux, Bordeaux, FranceUniv. Bordeaux, Bordeaux, FranceInserm U1215 - Neurocentre Magendie, Bordeaux, FranceCHU de Bordeaux, Bordeaux, FranceUniv. Bordeaux, Bordeaux, FranceInserm U1215 - Neurocentre Magendie, Bordeaux, FranceCHU de Bordeaux, Bordeaux, FranceBackground and purpose: Whether some gray matter (GM) regions are differentially vulnerable at the early stages of MS is still unknown. The objective of this study is to investigate whether deep and cortical GM are differentially vulnerable after a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS).Methods: Fifty-six patients with CIS (PwCIS) and 38 healthy controls (HC) had conventional and diffusion tensor imaging (DTI) at baseline and 46 PwCIS and 20 HC were rescanned after 1 year. Deep GM (DGM) volumes, cortical thickness (CTh), and DTI metrics (FA: fractional anisotropy; MD: mean diffusivity) within these structures were calculated for each participant at each time-point and compared between PwCIS and HC. Linear regression models were used to investigate whether baseline DTI parameters could predict GM volume loss over time.Results: At baseline, GM volumes did not differ between PwCIS and HC, but hippocampal MD was higher in PwCIS than HC (p < 0.01). Over 1 year, GM alterations became more widespread with putamen and hippocampus volumes decreasing in PwCIS (p < 0.01), and cortical thinning in different parts of the cortex along with a significant increase of MD. Hippocampus MD at baseline could predict its volume loss (R2 = 0.159; p < 0.05) and cortical thinning was associated to microstructural damage (Spearman's rho ranging from −0.424 to −0.603 with p < 0.003).Conclusion: Along with MS being a diffuse inflammatory disease, GM showed a differential vulnerability at the early stage spreading from hippocampus to the cortex. Hippocampus volume loss could be predicted by its MD at baseline.https://www.frontiersin.org/article/10.3389/fneur.2018.00824/fullmultiple sclerosisMRIdiffusion tensor imaginggray matteratrophyclinically isolated syndrome |
| spellingShingle | Ismail Koubiyr Ismail Koubiyr Mathilde Deloire Pierrick Coupé Cécile Dulau Pierre Besson Amandine Moroso Amandine Moroso Vincent Planche Vincent Planche Vincent Planche Thomas Tourdias Thomas Tourdias Thomas Tourdias Bruno Brochet Bruno Brochet Bruno Brochet Aurélie Ruet Aurélie Ruet Aurélie Ruet Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated Syndrome Frontiers in Neurology multiple sclerosis MRI diffusion tensor imaging gray matter atrophy clinically isolated syndrome |
| title | Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated Syndrome |
| title_full | Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated Syndrome |
| title_fullStr | Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated Syndrome |
| title_full_unstemmed | Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated Syndrome |
| title_short | Differential Gray Matter Vulnerability in the 1 Year Following a Clinically Isolated Syndrome |
| title_sort | differential gray matter vulnerability in the 1 year following a clinically isolated syndrome |
| topic | multiple sclerosis MRI diffusion tensor imaging gray matter atrophy clinically isolated syndrome |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00824/full |
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