Effect of CRISPR Knockout of AXIN1 or ARID1A on Proliferation and Migration of Porcine Hepatocellular Carcinoma

Effect of CRISPR Knockout of AXIN1 or ARID1A on Proliferation and Migration of Porcine Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is an aggressive disease lacking effective treatment. Animal models of HCC are necessary for preclinical evaluation of the safety and efficacy of novel therapeutics. Large animal models of HCC allow testing image-guided locoregional therapies, which are widely used in...

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Bibliographic Details
Main Authors: Lobna Elkhadragy, Kimia Dasteh Goli, William M. Totura, Maximillian J. Carlino, Maureen R. Regan, Grace Guzman, Lawrence B. Schook, Ron C. Gaba, Kyle M. Schachtschneider
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
liver cancer
hepatocellular carcinoma
porcine models
ARID1A
AXIN1
CRISPR
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.904031/full

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