Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice
Abstract Ortho-eugenol is a synthetic derivative from eugenol, the major compound of clove essential oil, which has demonstrated antidepressant and antinociceptive effects in pioneering studies. Additionally, its effects appear to be dependent on the noradrenergic and dopaminergic systems. Depressio...
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| Format: | Article |
| Language: | English |
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Instituto Internacional de Ecologia
2023-08-01
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| Series: | Brazilian Journal of Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100831&tlng=en |
| _version_ | 1797739636999585792 |
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| author | R. Godoy A. B. Macedo K. Y. Gervazio L. R. Ribeiro J. L. F. Lima M. G. S. S. Salvadori |
| author_facet | R. Godoy A. B. Macedo K. Y. Gervazio L. R. Ribeiro J. L. F. Lima M. G. S. S. Salvadori |
| author_sort | R. Godoy |
| collection | DOAJ |
| description | Abstract Ortho-eugenol is a synthetic derivative from eugenol, the major compound of clove essential oil, which has demonstrated antidepressant and antinociceptive effects in pioneering studies. Additionally, its effects appear to be dependent on the noradrenergic and dopaminergic systems. Depression and anxiety disorders are known to share a great overlap in their pathophysiology, and many drugs are effective in the treatment of both diseases. Furthermore, high levels of anxiety are related to working memory deficits and increased oxidative stress. Thus, in this study we investigated the effects of acute treatment of ortho-eugenol, at 50, 75 and 100 mg/kg, on anxiety, working memory and oxidative stress in male Swiss mice. Our results show that the 100 mg/kg dose increased the number of head-dips and reduced the latency in the hole-board test. The 50 mg/kg dose reduced malondialdehyde levels in the prefrontal cortex and the number of Y-maze entries compared to the MK-801-induced hyperlocomotion group. All doses reduced nitrite levels in the hippocampus. It was also possible to assess a statistical correlation between the reduction of oxidative stress and hyperlocomotion after the administration of ortho-eugenol. However, acute treatment was not able to prevent working memory deficits. Therefore, the present study shows that ortho-eugenol has an anxiolytic and antioxidant effect, and was able to prevent substance-induced hyperlocomotion. Our results contribute to the elucidation of the pharmacological profile of ortho-eugenol, as well as to direct further studies that seek to investigate its possible clinical applications. |
| first_indexed | 2024-03-12T14:01:05Z |
| format | Article |
| id | doaj.art-b845de382a3644fcaba54d5d327f60c6 |
| institution | Directory Open Access Journal |
| issn | 1678-4375 |
| language | English |
| last_indexed | 2024-03-12T14:01:05Z |
| publishDate | 2023-08-01 |
| publisher | Instituto Internacional de Ecologia |
| record_format | Article |
| series | Brazilian Journal of Biology |
| spelling | doaj.art-b845de382a3644fcaba54d5d327f60c62023-08-22T07:40:15ZengInstituto Internacional de EcologiaBrazilian Journal of Biology1678-43752023-08-018310.1590/1519-6984.271785Effects of ortho-eugenol on anxiety, working memory and oxidative stress in miceR. Godoyhttps://orcid.org/0000-0001-9569-3898A. B. Macedohttps://orcid.org/0000-0003-0065-5974K. Y. Gervaziohttps://orcid.org/0000-0002-4050-2246L. R. Ribeirohttps://orcid.org/0000-0002-8442-4075J. L. F. Limahttps://orcid.org/0000-0002-3631-8788M. G. S. S. Salvadorihttps://orcid.org/0000-0002-4674-7922Abstract Ortho-eugenol is a synthetic derivative from eugenol, the major compound of clove essential oil, which has demonstrated antidepressant and antinociceptive effects in pioneering studies. Additionally, its effects appear to be dependent on the noradrenergic and dopaminergic systems. Depression and anxiety disorders are known to share a great overlap in their pathophysiology, and many drugs are effective in the treatment of both diseases. Furthermore, high levels of anxiety are related to working memory deficits and increased oxidative stress. Thus, in this study we investigated the effects of acute treatment of ortho-eugenol, at 50, 75 and 100 mg/kg, on anxiety, working memory and oxidative stress in male Swiss mice. Our results show that the 100 mg/kg dose increased the number of head-dips and reduced the latency in the hole-board test. The 50 mg/kg dose reduced malondialdehyde levels in the prefrontal cortex and the number of Y-maze entries compared to the MK-801-induced hyperlocomotion group. All doses reduced nitrite levels in the hippocampus. It was also possible to assess a statistical correlation between the reduction of oxidative stress and hyperlocomotion after the administration of ortho-eugenol. However, acute treatment was not able to prevent working memory deficits. Therefore, the present study shows that ortho-eugenol has an anxiolytic and antioxidant effect, and was able to prevent substance-induced hyperlocomotion. Our results contribute to the elucidation of the pharmacological profile of ortho-eugenol, as well as to direct further studies that seek to investigate its possible clinical applications.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100831&tlng=enessential oilsanxiolyticlipid peroxidationhyperlocomotionpsychopharmacology |
| spellingShingle | R. Godoy A. B. Macedo K. Y. Gervazio L. R. Ribeiro J. L. F. Lima M. G. S. S. Salvadori Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice Brazilian Journal of Biology essential oils anxiolytic lipid peroxidation hyperlocomotion psychopharmacology |
| title | Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice |
| title_full | Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice |
| title_fullStr | Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice |
| title_full_unstemmed | Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice |
| title_short | Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice |
| title_sort | effects of ortho eugenol on anxiety working memory and oxidative stress in mice |
| topic | essential oils anxiolytic lipid peroxidation hyperlocomotion psychopharmacology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100831&tlng=en |
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