Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations
Abstract Habituation of wild great apes for tourism and research has had a significant positive effect on the conservation of these species. However, risks associated with such activities have been identified, specifically the transmission of human respiratory viruses to wild great apes, causing hig...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-11-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-14769-z |
| _version_ | 1819040057704579072 |
|---|---|
| author | Sophie Köndgen Sebastien Calvignac-Spencer Kim Grützmacher Verena Keil Kerstin Mätz-Rensing Kathrin Nowak Sonja Metzger John Kiyang Antina Lübke-Becker Tobias Deschner Roman M. Wittig Felix Lankester Fabian H. Leendertz |
| author_facet | Sophie Köndgen Sebastien Calvignac-Spencer Kim Grützmacher Verena Keil Kerstin Mätz-Rensing Kathrin Nowak Sonja Metzger John Kiyang Antina Lübke-Becker Tobias Deschner Roman M. Wittig Felix Lankester Fabian H. Leendertz |
| author_sort | Sophie Köndgen |
| collection | DOAJ |
| description | Abstract Habituation of wild great apes for tourism and research has had a significant positive effect on the conservation of these species. However, risks associated with such activities have been identified, specifically the transmission of human respiratory viruses to wild great apes, causing high morbidity and, occasionally, mortality. Here, we investigate the source of bacterial-viral co-infections in wild and captive chimpanzee communities in the course of several respiratory disease outbreaks. Molecular analyses showed that human respiratory syncytial viruses (HRSV) and human metapneumoviruses (HMPV) were involved in the etiology of the disease. In addition our analysis provide evidence for coinfection with Streptococcus (S.) pneumoniae. Characterisation of isolates from wild chimpanzees point towards a human origin of these bacteria. Transmission of these bacteria is of concern because – in contrast to HRSV and HMPV - S. pneumoniae can become part of the nasopharyngeal flora, contributing to the severity of respiratory disease progression. Furthermore these bacteria have the potential to spread to other individuals in the community and ultimately into the population. Targeted vaccination programs could be used to vaccinate habituated great apes but also human populations around great ape habitats, bringing health benefits to both humans and wild great apes. |
| first_indexed | 2024-12-21T09:03:03Z |
| format | Article |
| id | doaj.art-b84705b079a0487baf1e4833b465abfd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T09:03:03Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b84705b079a0487baf1e4833b465abfd2022-12-21T19:09:25ZengNature PortfolioScientific Reports2045-23222017-11-01711810.1038/s41598-017-14769-zEvidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populationsSophie Köndgen0Sebastien Calvignac-Spencer1Kim Grützmacher2Verena Keil3Kerstin Mätz-Rensing4Kathrin Nowak5Sonja Metzger6John Kiyang7Antina Lübke-Becker8Tobias Deschner9Roman M. Wittig10Felix Lankester11Fabian H. Leendertz12Epidemiology of highly pathogenic microorganisms, Robert Koch-InstituteEpidemiology of highly pathogenic microorganisms, Robert Koch-InstituteEpidemiology of highly pathogenic microorganisms, Robert Koch-InstituteEpidemiology of highly pathogenic microorganisms, Robert Koch-InstituteDepartment of Pathology, German Primate CenterEpidemiology of highly pathogenic microorganisms, Robert Koch-InstituteMax Planck Institute for Evolutionary Anthropology, Department of PrimatologyLimbe Wildlife CentreBerlin Institute of Microbiology and Epizootics, Freie Universität BerlinMax Planck Institute for Evolutionary Anthropology, Department of PrimatologyMax Planck Institute for Evolutionary Anthropology, Department of PrimatologyLimbe Wildlife CentreEpidemiology of highly pathogenic microorganisms, Robert Koch-InstituteAbstract Habituation of wild great apes for tourism and research has had a significant positive effect on the conservation of these species. However, risks associated with such activities have been identified, specifically the transmission of human respiratory viruses to wild great apes, causing high morbidity and, occasionally, mortality. Here, we investigate the source of bacterial-viral co-infections in wild and captive chimpanzee communities in the course of several respiratory disease outbreaks. Molecular analyses showed that human respiratory syncytial viruses (HRSV) and human metapneumoviruses (HMPV) were involved in the etiology of the disease. In addition our analysis provide evidence for coinfection with Streptococcus (S.) pneumoniae. Characterisation of isolates from wild chimpanzees point towards a human origin of these bacteria. Transmission of these bacteria is of concern because – in contrast to HRSV and HMPV - S. pneumoniae can become part of the nasopharyngeal flora, contributing to the severity of respiratory disease progression. Furthermore these bacteria have the potential to spread to other individuals in the community and ultimately into the population. Targeted vaccination programs could be used to vaccinate habituated great apes but also human populations around great ape habitats, bringing health benefits to both humans and wild great apes.https://doi.org/10.1038/s41598-017-14769-z |
| spellingShingle | Sophie Köndgen Sebastien Calvignac-Spencer Kim Grützmacher Verena Keil Kerstin Mätz-Rensing Kathrin Nowak Sonja Metzger John Kiyang Antina Lübke-Becker Tobias Deschner Roman M. Wittig Felix Lankester Fabian H. Leendertz Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations Scientific Reports |
| title | Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations |
| title_full | Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations |
| title_fullStr | Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations |
| title_full_unstemmed | Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations |
| title_short | Evidence for Human Streptococcus pneumoniae in wild and captive chimpanzees: A potential threat to wild populations |
| title_sort | evidence for human streptococcus pneumoniae in wild and captive chimpanzees a potential threat to wild populations |
| url | https://doi.org/10.1038/s41598-017-14769-z |
| work_keys_str_mv | AT sophiekondgen evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT sebastiencalvignacspencer evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT kimgrutzmacher evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT verenakeil evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT kerstinmatzrensing evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT kathrinnowak evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT sonjametzger evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT johnkiyang evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT antinalubkebecker evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT tobiasdeschner evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT romanmwittig evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT felixlankester evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations AT fabianhleendertz evidenceforhumanstreptococcuspneumoniaeinwildandcaptivechimpanzeesapotentialthreattowildpopulations |