Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review
Abstract A 75‐year‐old woman presented at our hospital with bilateral visual impairment. Ophthalmological examination revealed multiple choroidal tumours. Chest computed tomography revealed a tumour shadow in the right lower lobe and multiple lymph node metastases in the mediastinum and pulmonary hi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.1262 |
| _version_ | 1797344905082699776 |
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| author | Takahiro Matsuyama Masashi Oniwa Kentaro Tsuruzono Shunsuke Yasuda Mikiko Yone Yuya Tomioka Akifumi Uchida Hideo Mitsuyama Shingo Kubota Takayuki Suetsugu Keiko Mizuno Hiromasa Inoue |
| author_facet | Takahiro Matsuyama Masashi Oniwa Kentaro Tsuruzono Shunsuke Yasuda Mikiko Yone Yuya Tomioka Akifumi Uchida Hideo Mitsuyama Shingo Kubota Takayuki Suetsugu Keiko Mizuno Hiromasa Inoue |
| author_sort | Takahiro Matsuyama |
| collection | DOAJ |
| description | Abstract A 75‐year‐old woman presented at our hospital with bilateral visual impairment. Ophthalmological examination revealed multiple choroidal tumours. Chest computed tomography revealed a tumour shadow in the right lower lobe and multiple lymph node metastases in the mediastinum and pulmonary hilum. Following a detailed examination, the patient was diagnosed with primary lung adenocarcinoma (cT1cN3M1c Stage IVB) with choroid metastases. The tumour proportion score of programmed death ligand 1 (PD‐L1) was 1% and EGFR exon 20 insertion mutations were also detected. The patient was administered combination chemotherapy with nivolumab and ipilimumab. Primary lung and metastatic tumours, including the choroid, were reduced, and visual disturbances improved completely. Herein, we describe a rare case in which a combination of chemotherapy with nivolumab and ipilimumab significantly reduced vision loss due to choroidal metastasis. |
| first_indexed | 2024-03-08T11:10:42Z |
| format | Article |
| id | doaj.art-b84839b5c62a42d09c3245c86a03923a |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-03-08T11:10:42Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-b84839b5c62a42d09c3245c86a03923a2024-01-26T11:13:00ZengWileyRespirology Case Reports2051-33802024-01-01121n/an/a10.1002/rcr2.1262Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature reviewTakahiro Matsuyama0Masashi Oniwa1Kentaro Tsuruzono2Shunsuke Yasuda3Mikiko Yone4Yuya Tomioka5Akifumi Uchida6Hideo Mitsuyama7Shingo Kubota8Takayuki Suetsugu9Keiko Mizuno10Hiromasa Inoue11Department of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima JapanAbstract A 75‐year‐old woman presented at our hospital with bilateral visual impairment. Ophthalmological examination revealed multiple choroidal tumours. Chest computed tomography revealed a tumour shadow in the right lower lobe and multiple lymph node metastases in the mediastinum and pulmonary hilum. Following a detailed examination, the patient was diagnosed with primary lung adenocarcinoma (cT1cN3M1c Stage IVB) with choroid metastases. The tumour proportion score of programmed death ligand 1 (PD‐L1) was 1% and EGFR exon 20 insertion mutations were also detected. The patient was administered combination chemotherapy with nivolumab and ipilimumab. Primary lung and metastatic tumours, including the choroid, were reduced, and visual disturbances improved completely. Herein, we describe a rare case in which a combination of chemotherapy with nivolumab and ipilimumab significantly reduced vision loss due to choroidal metastasis.https://doi.org/10.1002/rcr2.1262choroidal metastasisipilimumabnivolumabnon‐small cell lung cancervision loss |
| spellingShingle | Takahiro Matsuyama Masashi Oniwa Kentaro Tsuruzono Shunsuke Yasuda Mikiko Yone Yuya Tomioka Akifumi Uchida Hideo Mitsuyama Shingo Kubota Takayuki Suetsugu Keiko Mizuno Hiromasa Inoue Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review Respirology Case Reports choroidal metastasis ipilimumab nivolumab non‐small cell lung cancer vision loss |
| title | Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review |
| title_full | Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review |
| title_fullStr | Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review |
| title_full_unstemmed | Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review |
| title_short | Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review |
| title_sort | improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis a case report and literature review |
| topic | choroidal metastasis ipilimumab nivolumab non‐small cell lung cancer vision loss |
| url | https://doi.org/10.1002/rcr2.1262 |
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