LECTINS IN ANTI-CANCER STRATEGIES
The published during last few years data concerning communicative role of lectins (proteins and their complexes which recognize carbohydrates, glycoconjugates and their patterns) in on-duty supporting and increasing anticancer status of human immunity are analyzed. Examples of lectin-(glycoconjug...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2018-07-01
|
| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/652 |
| _version_ | 1826853358421409792 |
|---|---|
| author | M. V. Lakhtin V. M. Lakhtin V. A. Aleshkin M. S. Afanasiev S. S. Afanasiev |
| author_facet | M. V. Lakhtin V. M. Lakhtin V. A. Aleshkin M. S. Afanasiev S. S. Afanasiev |
| author_sort | M. V. Lakhtin |
| collection | DOAJ |
| description | The published during last few years data concerning communicative role of lectins (proteins and their complexes which recognize carbohydrates, glycoconjugates and their patterns) in on-duty supporting and increasing anticancer status of human immunity are analyzed. Examples of lectin-(glycoconjugate pattern) strategies, approaches and tactic variants in study and development of anticancer treatments, principle variants of therapy, possible vaccines in 35 cases of blood connected tumors (leukemia, lymphomas, others), solid tumors (carcinomas, sarcoma, cancers of vaginal biotopes, prostate, bladder, colon, other intestinal compartments, pancreas, liver, kidneys, others) and cancer cell lines are described and systemized. The list of mostly used communicative lectins (pattern recognition receptors, their soluble forms, other soluble lectins possessing specificities of importance) involving in key intercellular cascades and pathway co-functioning is presented. The regulation of resulting expression of distinct active lectins (available and hetero/di/oligomeric forms) and their interaction to adequate glycoconjugate patterns as well as influence distribution of co-functioning lectins and antigens CD between populations and subpopulations of antigen-presented cells (dendritic cells cDC, mDC, moDC, pDC; macrophages M2 and M1), mucosal M-cells, NK-cells play key role for choice and development of anticancer complex procedures increasing innate and innate-coupled immune responses. Prospects of (receptor lectin)-dependent intercellular communications and targeting glycoconjugate constructions into innate immunity cells for therapy of cancer and development of anticancer vaccines are evaluated and discussed. |
| first_indexed | 2024-03-08T12:17:19Z |
| format | Article |
| id | doaj.art-b848644ad4744ae1a6a8b0fa3f45c915 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2025-02-16T17:24:08Z |
| publishDate | 2018-07-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-b848644ad4744ae1a6a8b0fa3f45c9152025-01-27T16:48:54ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962018-07-0134697710.29413/ABS.2018-3.4.11644LECTINS IN ANTI-CANCER STRATEGIESM. V. Lakhtin0V. M. Lakhtin1V. A. Aleshkin2M. S. Afanasiev3S. S. Afanasiev4G.N. Gabrichevsky Research Institute for Epidemiology and MicrobiologyG.N. Gabrichevsky Research Institute for Epidemiology and MicrobiologyG.N. Gabrichevsky Research Institute for Epidemiology and MicrobiologyThe First Sechenov Moscow State Medical UniversityG.N. Gabrichevsky Research Institute for Epidemiology and MicrobiologyThe published during last few years data concerning communicative role of lectins (proteins and their complexes which recognize carbohydrates, glycoconjugates and their patterns) in on-duty supporting and increasing anticancer status of human immunity are analyzed. Examples of lectin-(glycoconjugate pattern) strategies, approaches and tactic variants in study and development of anticancer treatments, principle variants of therapy, possible vaccines in 35 cases of blood connected tumors (leukemia, lymphomas, others), solid tumors (carcinomas, sarcoma, cancers of vaginal biotopes, prostate, bladder, colon, other intestinal compartments, pancreas, liver, kidneys, others) and cancer cell lines are described and systemized. The list of mostly used communicative lectins (pattern recognition receptors, their soluble forms, other soluble lectins possessing specificities of importance) involving in key intercellular cascades and pathway co-functioning is presented. The regulation of resulting expression of distinct active lectins (available and hetero/di/oligomeric forms) and their interaction to adequate glycoconjugate patterns as well as influence distribution of co-functioning lectins and antigens CD between populations and subpopulations of antigen-presented cells (dendritic cells cDC, mDC, moDC, pDC; macrophages M2 and M1), mucosal M-cells, NK-cells play key role for choice and development of anticancer complex procedures increasing innate and innate-coupled immune responses. Prospects of (receptor lectin)-dependent intercellular communications and targeting glycoconjugate constructions into innate immunity cells for therapy of cancer and development of anticancer vaccines are evaluated and discussed.https://www.actabiomedica.ru/jour/article/view/652malignant tumorsreceptor lectinsglycoconjugatesadjuvantscell targetingdendritic cellsmacrophagesm-cellsnk-cellscell subpopulationsinnate immunityanticancer therapyanticancer v accines |
| spellingShingle | M. V. Lakhtin V. M. Lakhtin V. A. Aleshkin M. S. Afanasiev S. S. Afanasiev LECTINS IN ANTI-CANCER STRATEGIES Acta Biomedica Scientifica malignant tumors receptor lectins glycoconjugates adjuvants cell targeting dendritic cells macrophages m-cells nk-cells cell subpopulations innate immunity anticancer therapy anticancer v accines |
| title | LECTINS IN ANTI-CANCER STRATEGIES |
| title_full | LECTINS IN ANTI-CANCER STRATEGIES |
| title_fullStr | LECTINS IN ANTI-CANCER STRATEGIES |
| title_full_unstemmed | LECTINS IN ANTI-CANCER STRATEGIES |
| title_short | LECTINS IN ANTI-CANCER STRATEGIES |
| title_sort | lectins in anti cancer strategies |
| topic | malignant tumors receptor lectins glycoconjugates adjuvants cell targeting dendritic cells macrophages m-cells nk-cells cell subpopulations innate immunity anticancer therapy anticancer v accines |
| url | https://www.actabiomedica.ru/jour/article/view/652 |
| work_keys_str_mv | AT mvlakhtin lectinsinanticancerstrategies AT vmlakhtin lectinsinanticancerstrategies AT vaaleshkin lectinsinanticancerstrategies AT msafanasiev lectinsinanticancerstrategies AT ssafanasiev lectinsinanticancerstrategies |