The efficacy and safety of selective COX-2 inhibitors for postoperative pain management in patients after total knee/hip arthroplasty: a meta-analysis
Abstract Background Many selective cyclooxygenase (COX-2) inhibitors are currently used in clinical practice. COX-2 inhibitors have good anti-inflammatory, analgesic, antipyretic effects, and gastrointestinal safety. However, the analgesic effects and adverse reactions of COX-2 after total knee/hip...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-020-1569-z |
| _version_ | 1817997358199209984 |
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| author | Mingyang Jiang Huachu Deng Xuxu Chen Yunni Lin Xiaoyong Xie Zhandong Bo |
| author_facet | Mingyang Jiang Huachu Deng Xuxu Chen Yunni Lin Xiaoyong Xie Zhandong Bo |
| author_sort | Mingyang Jiang |
| collection | DOAJ |
| description | Abstract Background Many selective cyclooxygenase (COX-2) inhibitors are currently used in clinical practice. COX-2 inhibitors have good anti-inflammatory, analgesic, antipyretic effects, and gastrointestinal safety. However, the analgesic effects and adverse reactions of COX-2 after total knee/hip arthroplasty (TKA/THA) are not fully known. Objective To evaluate the efficacy and safety of selective COX-2 inhibitors in postoperative pain management in patients receiving TKA/THA. Methods Randomized controlled trials (RCTs) were retrieved from medical literature databases. Risk ratios (RR) Std mean difference (SMD) and 95% confidence intervals (CI) were calculated to analyze the primary and safety endpoints. Results In total, 18 articles (23 trial comparisons) were retrieved comprising 3104 patients. Among them, 1910 patients (61.5%) were randomized to the experimental group whereas 1194 patients (38.5%) were randomized to the control group. The primary endpoints were the patients’ VAS score at rest or on ambulation (within 3 days). We found that VAS score in patients that received selective COX-2 inhibitor was significantly lower compared to those of the control group. Conclusion This meta-analysis shows that selective COX-2 inhibitor therapy is effective, safe, and reliable in relieving postoperative pain of THA/TKA. |
| first_indexed | 2024-04-14T02:36:57Z |
| format | Article |
| id | doaj.art-b84b7324ee33403d94823b14aa61d774 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-14T02:36:57Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-b84b7324ee33403d94823b14aa61d7742022-12-22T02:17:22ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2020-02-0115111210.1186/s13018-020-1569-zThe efficacy and safety of selective COX-2 inhibitors for postoperative pain management in patients after total knee/hip arthroplasty: a meta-analysisMingyang Jiang0Huachu Deng1Xuxu Chen2Yunni Lin3Xiaoyong Xie4Zhandong Bo5Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical UniversityGuangxi Medical UniversityGuangxi Medical UniversityGuangxi Medical UniversityGuangxi Medical UniversityDepartment of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical UniversityAbstract Background Many selective cyclooxygenase (COX-2) inhibitors are currently used in clinical practice. COX-2 inhibitors have good anti-inflammatory, analgesic, antipyretic effects, and gastrointestinal safety. However, the analgesic effects and adverse reactions of COX-2 after total knee/hip arthroplasty (TKA/THA) are not fully known. Objective To evaluate the efficacy and safety of selective COX-2 inhibitors in postoperative pain management in patients receiving TKA/THA. Methods Randomized controlled trials (RCTs) were retrieved from medical literature databases. Risk ratios (RR) Std mean difference (SMD) and 95% confidence intervals (CI) were calculated to analyze the primary and safety endpoints. Results In total, 18 articles (23 trial comparisons) were retrieved comprising 3104 patients. Among them, 1910 patients (61.5%) were randomized to the experimental group whereas 1194 patients (38.5%) were randomized to the control group. The primary endpoints were the patients’ VAS score at rest or on ambulation (within 3 days). We found that VAS score in patients that received selective COX-2 inhibitor was significantly lower compared to those of the control group. Conclusion This meta-analysis shows that selective COX-2 inhibitor therapy is effective, safe, and reliable in relieving postoperative pain of THA/TKA.https://doi.org/10.1186/s13018-020-1569-zSelective COX-2 inhibitorTotal knee arthroplastyTotal hip arthroplastyMeta-analysis |
| spellingShingle | Mingyang Jiang Huachu Deng Xuxu Chen Yunni Lin Xiaoyong Xie Zhandong Bo The efficacy and safety of selective COX-2 inhibitors for postoperative pain management in patients after total knee/hip arthroplasty: a meta-analysis Journal of Orthopaedic Surgery and Research Selective COX-2 inhibitor Total knee arthroplasty Total hip arthroplasty Meta-analysis |
| title | The efficacy and safety of selective COX-2 inhibitors for postoperative pain management in patients after total knee/hip arthroplasty: a meta-analysis |
| title_full | The efficacy and safety of selective COX-2 inhibitors for postoperative pain management in patients after total knee/hip arthroplasty: a meta-analysis |
| title_fullStr | The efficacy and safety of selective COX-2 inhibitors for postoperative pain management in patients after total knee/hip arthroplasty: a meta-analysis |
| title_full_unstemmed | The efficacy and safety of selective COX-2 inhibitors for postoperative pain management in patients after total knee/hip arthroplasty: a meta-analysis |
| title_short | The efficacy and safety of selective COX-2 inhibitors for postoperative pain management in patients after total knee/hip arthroplasty: a meta-analysis |
| title_sort | efficacy and safety of selective cox 2 inhibitors for postoperative pain management in patients after total knee hip arthroplasty a meta analysis |
| topic | Selective COX-2 inhibitor Total knee arthroplasty Total hip arthroplasty Meta-analysis |
| url | https://doi.org/10.1186/s13018-020-1569-z |
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