The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study
Type 1 diabetes mellitus (T1DM) represents one of the most frequent chronic illnesses affecting children. The early diagnosis of this disease is crucial, as it plays a key role in preventing the development of a life-threatening acute complication: diabetic ketoacidosis. The etiopathogenetic role of...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/6/551 |
| _version_ | 1797530269524164608 |
|---|---|
| author | Anca Andreea Boboc Carmen Nicoleta Novac Maria Teodora Ilie Mara Ioana Ieșanu Felicia Galoș Mihaela Bălgrădean Elena Camelia Berghea Marcela Daniela Ionescu |
| author_facet | Anca Andreea Boboc Carmen Nicoleta Novac Maria Teodora Ilie Mara Ioana Ieșanu Felicia Galoș Mihaela Bălgrădean Elena Camelia Berghea Marcela Daniela Ionescu |
| author_sort | Anca Andreea Boboc |
| collection | DOAJ |
| description | Type 1 diabetes mellitus (T1DM) represents one of the most frequent chronic illnesses affecting children. The early diagnosis of this disease is crucial, as it plays a key role in preventing the development of a life-threatening acute complication: diabetic ketoacidosis. The etiopathogenetic role of viral infections has long been suggested and emerging data are pointing towards a complex bidirectional relationship between diabetes and COVID-19. The aim of this study is to assess the impact of the COVID-19 pandemic on the incidence and severity of new T1DM cases in children in Romania. We analyzed the differences between a group of 312 patients diagnosed with T1DM in the period 2003–2019 and a group of 147 children diagnosed during the pandemic. The data were investigated using statistical analysis of a series of relevant variables. The total number of newly diagnosed T1DM increased by 30.08% in the period March 2020–February 2021 compared to the previous years. The patients in the pandemic group had a higher mean age at the onset of T1DM, were less frequently living in an urban area, and presented a higher mean value of HbA1c. Diabetic ketoacidosis at the onset of T1DM was 67.40% more frequent, and a higher percentage of these patients presented with a severe form. The duration of T1DM symptoms did not differ significantly between the two groups. A number of 8 patients associated SARS-CoV-2 infection at the time of T1DM diagnosis. |
| first_indexed | 2024-03-10T10:26:38Z |
| format | Article |
| id | doaj.art-b84bc7e13935480a84272f26f8e8f762 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T10:26:38Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-b84bc7e13935480a84272f26f8e8f7622023-11-21T23:58:32ZengMDPI AGJournal of Personalized Medicine2075-44262021-06-0111655110.3390/jpm11060551The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort StudyAnca Andreea Boboc0Carmen Nicoleta Novac1Maria Teodora Ilie2Mara Ioana Ieșanu3Felicia Galoș4Mihaela Bălgrădean5Elena Camelia Berghea6Marcela Daniela Ionescu7Marie Curie Emergency Children’s Hospital, 041451 Bucharest, RomaniaMarie Curie Emergency Children’s Hospital, 041451 Bucharest, RomaniaMarie Curie Emergency Children’s Hospital, 041451 Bucharest, RomaniaMarie Curie Emergency Children’s Hospital, 041451 Bucharest, RomaniaMarie Curie Emergency Children’s Hospital, 041451 Bucharest, RomaniaMarie Curie Emergency Children’s Hospital, 041451 Bucharest, RomaniaMarie Curie Emergency Children’s Hospital, 041451 Bucharest, RomaniaMarie Curie Emergency Children’s Hospital, 041451 Bucharest, RomaniaType 1 diabetes mellitus (T1DM) represents one of the most frequent chronic illnesses affecting children. The early diagnosis of this disease is crucial, as it plays a key role in preventing the development of a life-threatening acute complication: diabetic ketoacidosis. The etiopathogenetic role of viral infections has long been suggested and emerging data are pointing towards a complex bidirectional relationship between diabetes and COVID-19. The aim of this study is to assess the impact of the COVID-19 pandemic on the incidence and severity of new T1DM cases in children in Romania. We analyzed the differences between a group of 312 patients diagnosed with T1DM in the period 2003–2019 and a group of 147 children diagnosed during the pandemic. The data were investigated using statistical analysis of a series of relevant variables. The total number of newly diagnosed T1DM increased by 30.08% in the period March 2020–February 2021 compared to the previous years. The patients in the pandemic group had a higher mean age at the onset of T1DM, were less frequently living in an urban area, and presented a higher mean value of HbA1c. Diabetic ketoacidosis at the onset of T1DM was 67.40% more frequent, and a higher percentage of these patients presented with a severe form. The duration of T1DM symptoms did not differ significantly between the two groups. A number of 8 patients associated SARS-CoV-2 infection at the time of T1DM diagnosis.https://www.mdpi.com/2075-4426/11/6/551early diagnosistype 1 diabetes mellituschildrenCOVID-19epidemicsdiabetic ketoacidosis |
| spellingShingle | Anca Andreea Boboc Carmen Nicoleta Novac Maria Teodora Ilie Mara Ioana Ieșanu Felicia Galoș Mihaela Bălgrădean Elena Camelia Berghea Marcela Daniela Ionescu The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study Journal of Personalized Medicine early diagnosis type 1 diabetes mellitus children COVID-19 epidemics diabetic ketoacidosis |
| title | The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study |
| title_full | The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study |
| title_fullStr | The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study |
| title_full_unstemmed | The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study |
| title_short | The Impact of SARS-CoV-2 Pandemic on the New Cases of T1DM in Children. A Single-Centre Cohort Study |
| title_sort | impact of sars cov 2 pandemic on the new cases of t1dm in children a single centre cohort study |
| topic | early diagnosis type 1 diabetes mellitus children COVID-19 epidemics diabetic ketoacidosis |
| url | https://www.mdpi.com/2075-4426/11/6/551 |
| work_keys_str_mv | AT ancaandreeaboboc theimpactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT carmennicoletanovac theimpactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT mariateodorailie theimpactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT maraioanaiesanu theimpactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT feliciagalos theimpactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT mihaelabalgradean theimpactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT elenacameliaberghea theimpactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT marceladanielaionescu theimpactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT ancaandreeaboboc impactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT carmennicoletanovac impactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT mariateodorailie impactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT maraioanaiesanu impactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT feliciagalos impactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT mihaelabalgradean impactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT elenacameliaberghea impactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy AT marceladanielaionescu impactofsarscov2pandemiconthenewcasesoft1dminchildrenasinglecentrecohortstudy |