The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal study
Acquired immune deficiency syndrome infection can lead to cognitive dysfunction represented by changes in the default mode network. Most recent studies have been cross-sectional and thus have not revealed dynamic changes in the default mode network following acquired immune deficiency syndrome infec...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1542;epage=1547;aulast=Tang |
| _version_ | 1828065958120390656 |
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| author | Zhen-Chao Tang Jiao-Jiao Liu Xue-Tong Ding Dan Liu Hong-Wei Qiao Xiao-Jie Huang Hui Zhang Jie Tian Hong-Jun Li |
| author_facet | Zhen-Chao Tang Jiao-Jiao Liu Xue-Tong Ding Dan Liu Hong-Wei Qiao Xiao-Jie Huang Hui Zhang Jie Tian Hong-Jun Li |
| author_sort | Zhen-Chao Tang |
| collection | DOAJ |
| description | Acquired immune deficiency syndrome infection can lead to cognitive dysfunction represented by changes in the default mode network. Most recent studies have been cross-sectional and thus have not revealed dynamic changes in the default mode network following acquired immune deficiency syndrome infection and antiretroviral therapy. Specifically, when brain imaging data at only one time point are analyzed, determining the duration at which the default mode network is the most effective following antiretroviral therapy after the occurrence of acquired immune deficiency syndrome. However, because infection times and other factors are often uncertain, longitudinal studies cannot be conducted directly in the clinic. Therefore, in this study, we performed a longitudinal study on the dynamic changes in the default mode network over time in a rhesus monkey model of simian immunodeficiency virus infection. We found marked changes in default mode network connectivity in 11 pairs of regions of interest at baseline and 10 days and 4 weeks after virus inoculation. Significant interactions between treatment and time were observed in the default mode network connectivity of regions of interest pairs area 31/V6.R and area 8/frontal eye field (FEF). L, area 8/FEF.L and caudal temporal parietal occipital area (TPOC).R, and area 31/V6.R and TPOC.L. ART administered 4 weeks after infection not only interrupted the progress of simian immunodeficiency virus infection but also preserved brain function to a large extent. These findings suggest that the default mode network is affected in the early stage of simian immunodeficiency virus infection and that it may serve as a potential biomarker for early changes in brain function and an objective indicator for making early clinical intervention decisions. |
| first_indexed | 2024-04-10T23:23:25Z |
| format | Article |
| id | doaj.art-b84cad65470349cfbd60716ad03f2118 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-10T23:23:25Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-b84cad65470349cfbd60716ad03f21182023-01-12T13:29:30ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742023-01-011871542154710.4103/1673-5374.360244The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal studyZhen-Chao TangJiao-Jiao LiuXue-Tong DingDan LiuHong-Wei QiaoXiao-Jie HuangHui ZhangJie TianHong-Jun LiAcquired immune deficiency syndrome infection can lead to cognitive dysfunction represented by changes in the default mode network. Most recent studies have been cross-sectional and thus have not revealed dynamic changes in the default mode network following acquired immune deficiency syndrome infection and antiretroviral therapy. Specifically, when brain imaging data at only one time point are analyzed, determining the duration at which the default mode network is the most effective following antiretroviral therapy after the occurrence of acquired immune deficiency syndrome. However, because infection times and other factors are often uncertain, longitudinal studies cannot be conducted directly in the clinic. Therefore, in this study, we performed a longitudinal study on the dynamic changes in the default mode network over time in a rhesus monkey model of simian immunodeficiency virus infection. We found marked changes in default mode network connectivity in 11 pairs of regions of interest at baseline and 10 days and 4 weeks after virus inoculation. Significant interactions between treatment and time were observed in the default mode network connectivity of regions of interest pairs area 31/V6.R and area 8/frontal eye field (FEF). L, area 8/FEF.L and caudal temporal parietal occipital area (TPOC).R, and area 31/V6.R and TPOC.L. ART administered 4 weeks after infection not only interrupted the progress of simian immunodeficiency virus infection but also preserved brain function to a large extent. These findings suggest that the default mode network is affected in the early stage of simian immunodeficiency virus infection and that it may serve as a potential biomarker for early changes in brain function and an objective indicator for making early clinical intervention decisions.http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1542;epage=1547;aulast=Tangacquired immune deficiency syndrome; analysis of variance; antiretroviral therapy; default mode network; functional magnetic resonance imaging; human immunodeficiency virus; longitudinal study; rhesus monkeys; simian immunodeficiency virus; siv-mac239 |
| spellingShingle | Zhen-Chao Tang Jiao-Jiao Liu Xue-Tong Ding Dan Liu Hong-Wei Qiao Xiao-Jie Huang Hui Zhang Jie Tian Hong-Jun Li The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal study Neural Regeneration Research acquired immune deficiency syndrome; analysis of variance; antiretroviral therapy; default mode network; functional magnetic resonance imaging; human immunodeficiency virus; longitudinal study; rhesus monkeys; simian immunodeficiency virus; siv-mac239 |
| title | The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal study |
| title_full | The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal study |
| title_fullStr | The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal study |
| title_full_unstemmed | The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal study |
| title_short | The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal study |
| title_sort | default mode network is affected in the early stage of simian immunodeficiency virus infection a longitudinal study |
| topic | acquired immune deficiency syndrome; analysis of variance; antiretroviral therapy; default mode network; functional magnetic resonance imaging; human immunodeficiency virus; longitudinal study; rhesus monkeys; simian immunodeficiency virus; siv-mac239 |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1542;epage=1547;aulast=Tang |
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