Insulin is a key modulator of fetoplacental endothelium metabolic disturbances in gestational diabetes mellitus

Insulin is a key modulator of fetoplacental endothelium metabolic disturbances in gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is a disease of the mother that associates with altered fetoplacental vascular function. GDM–associated maternal hyperglycaemia result in fetal hyperglycaemia, a condition that leads to fetal hyperinsulinemia and altered L-arginine transport and synthesis of nitri...

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Bibliographic Details
Main Authors: Luis eSobrevia, Rocío eSalsoso, Bárbara eFuenzalida, Eric eBarros, Lilian eToledo, Carolina ePizarro, Luis eSilva, Mario eSubiabre, Roberto eVillalobos, Joaquín eAraos, Fernando eToledo, Marcelo eGonzalez, Jaime eGutiérrez, Marcelo eFarías, Fabian ePardo, Indira eChiarello, Andrea eLeiva
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Physiology
Subjects:
Endoplasmic Reticulum Stress
Endothelium
Insulin
Lipids
Placenta
Angiogenesis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00119/full

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