Associations of Stress and Appetite Hormones with Binge Eating in Females with Anorexia Nervosa after Weight Restoration: A Longitudinal Study
Binge eating is a transdiagnostic eating disorder symptom that can occur in patients with anorexia nervosa (AN), persisting after weight restoration, and impeding their recovery. However, little is known about the biological predictors of binge eating after AN weight restoration. The goals of this e...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/10/1020 |
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| author | Ya-Ke Wu Kimberly A. Brownley Anna M. Bardone-Cone Cynthia M. Bulik Jessica H. Baker |
| author_facet | Ya-Ke Wu Kimberly A. Brownley Anna M. Bardone-Cone Cynthia M. Bulik Jessica H. Baker |
| author_sort | Ya-Ke Wu |
| collection | DOAJ |
| description | Binge eating is a transdiagnostic eating disorder symptom that can occur in patients with anorexia nervosa (AN), persisting after weight restoration, and impeding their recovery. However, little is known about the biological predictors of binge eating after AN weight restoration. The goals of this exploratory study of 73 females with AN were: (1) to examine changes in cortisol, the adrenocorticotropic hormone, norepinephrine, ghrelin (total and active), and leptin levels across the admission, discharge, and 3 months post-discharge from the inpatient AN weight restoration; and (2) to determine whether the target hormones were associated with objective or subjective binge eating (OBE or SBE). The participants completed the self-reported Eating Disorder Examination Questionnaire, Beck Anxiety Inventory, and Beck Depression Inventory-II, and provided fasting whole blood samples for hormone assays. The results showed significant changes in body mass index (BMI), cortisol, total ghrelin, and leptin levels over the three time points. The cortisol levels at admission and discharge were significantly associated with the number of SBE episodes at 3 months post-discharge. Findings suggest the need to replicate and confirm the role of cortisol in predicting the emergence of SBE and uncover the mechanisms underlying SBE and cortisol to prevent SBE and its negative consequences. |
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| format | Article |
| id | doaj.art-b84e16d96c9342dfa2c3709fce1432a9 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T06:28:13Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-b84e16d96c9342dfa2c3709fce1432a92023-11-22T18:49:22ZengMDPI AGJournal of Personalized Medicine2075-44262021-10-011110102010.3390/jpm11101020Associations of Stress and Appetite Hormones with Binge Eating in Females with Anorexia Nervosa after Weight Restoration: A Longitudinal StudyYa-Ke Wu0Kimberly A. Brownley1Anna M. Bardone-Cone2Cynthia M. Bulik3Jessica H. Baker4School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USABinge eating is a transdiagnostic eating disorder symptom that can occur in patients with anorexia nervosa (AN), persisting after weight restoration, and impeding their recovery. However, little is known about the biological predictors of binge eating after AN weight restoration. The goals of this exploratory study of 73 females with AN were: (1) to examine changes in cortisol, the adrenocorticotropic hormone, norepinephrine, ghrelin (total and active), and leptin levels across the admission, discharge, and 3 months post-discharge from the inpatient AN weight restoration; and (2) to determine whether the target hormones were associated with objective or subjective binge eating (OBE or SBE). The participants completed the self-reported Eating Disorder Examination Questionnaire, Beck Anxiety Inventory, and Beck Depression Inventory-II, and provided fasting whole blood samples for hormone assays. The results showed significant changes in body mass index (BMI), cortisol, total ghrelin, and leptin levels over the three time points. The cortisol levels at admission and discharge were significantly associated with the number of SBE episodes at 3 months post-discharge. Findings suggest the need to replicate and confirm the role of cortisol in predicting the emergence of SBE and uncover the mechanisms underlying SBE and cortisol to prevent SBE and its negative consequences.https://www.mdpi.com/2075-4426/11/10/1020loss of control eatingrenourishmentstress hormonesappetite hormones |
| spellingShingle | Ya-Ke Wu Kimberly A. Brownley Anna M. Bardone-Cone Cynthia M. Bulik Jessica H. Baker Associations of Stress and Appetite Hormones with Binge Eating in Females with Anorexia Nervosa after Weight Restoration: A Longitudinal Study Journal of Personalized Medicine loss of control eating renourishment stress hormones appetite hormones |
| title | Associations of Stress and Appetite Hormones with Binge Eating in Females with Anorexia Nervosa after Weight Restoration: A Longitudinal Study |
| title_full | Associations of Stress and Appetite Hormones with Binge Eating in Females with Anorexia Nervosa after Weight Restoration: A Longitudinal Study |
| title_fullStr | Associations of Stress and Appetite Hormones with Binge Eating in Females with Anorexia Nervosa after Weight Restoration: A Longitudinal Study |
| title_full_unstemmed | Associations of Stress and Appetite Hormones with Binge Eating in Females with Anorexia Nervosa after Weight Restoration: A Longitudinal Study |
| title_short | Associations of Stress and Appetite Hormones with Binge Eating in Females with Anorexia Nervosa after Weight Restoration: A Longitudinal Study |
| title_sort | associations of stress and appetite hormones with binge eating in females with anorexia nervosa after weight restoration a longitudinal study |
| topic | loss of control eating renourishment stress hormones appetite hormones |
| url | https://www.mdpi.com/2075-4426/11/10/1020 |
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