Screening Novel Vaccine Candidates for Leishmania Donovani by Combining Differential Proteomics and Immunoinformatics Analysis

Screening Novel Vaccine Candidates for Leishmania Donovani by Combining Differential Proteomics and Immunoinformatics Analysis

Visceral leishmaniasis (VL), also known as kala-azar, is the most dangerous form of leishmaniasis. Currently no effective vaccine is available for clinical use. Since the pathogenicity of different Leishmania strains is inconsistent, the differentially expressed proteins in Leishmania strains may pl...

Full description

Bibliographic Details
Main Authors:	Jianhui Zhang, Jiao Li, Kaifeng Hu, Qi Zhou, Xiaoxiao Chen, Jinlei He, Shuangshuang Yin, Yangjian Chi, Xuechun Liao, Yuying Xiao, Hanxiao Qin, Zhiwan Zheng, Jianping Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Immunology
Subjects:	Leishmania donovani vaccine immunoinformatics differentially expressed protein epitope prediction
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.902066/full

Similar Items

In-silico design of an immunoinformatics based multi-epitope vaccine against Leishmania donovani
by: Subhadip Saha, et al.
Published: (2022-08-01)

Genetic diversity analysis of Chinese Leishmania isolates and development of L. donovani complex-specific markers by RAPD
by: Dongmei Yuan, et al.
Published: (2021-05-01)

Integrative genomic, proteomic and phenotypic studies of Leishmania donovani strains revealed genetic features associated with virulence and antimony-resistance
by: Zhiwan Zheng, et al.
Published: (2020-10-01)

Active cutaneous leishmaniasis in Brazil, induced by Leishmania donovani chagasi
by: M. P. Oliveira Neto, et al.
Published: (1986-09-01)

First report of cutaneous leishmaniasis caused by Leishmania donovani in Ethiopia
by: Gashaw Azanaw Amare, et al.
Published: (2023-12-01)

Infecção experimental de Calomys callosus (Rodentia-Cricetidae) com Leishmania donovani chagasi (Laison, 1982) Experimental infection of Calomys callosus (Rodentia-Cricetidae) with Leishmania donovani
by: Dalva A. Mello, et al.
Published: (1984-08-01)

Structure and Antiparasitic Activity Relationship of Alkylphosphocholine Analogues against <i>Leishmania donovani</i>
by: Humera Ahmed, et al.
Published: (2020-07-01)

Sesamol Induces Apoptosis-Like Cell Death in Leishmania donovani
by: Rahat Ali, et al.
Published: (2021-10-01)

Prevalence of Leishmania donovani Infection in Humans and Dogs in Gadarif State, Sudan: A Diagnostic Comparison
by: Ahmed Osman Ahmed Abdalla, et al.
Published: (2024-03-01)

Leishmania donovani Exploits Tunneling Nanotubes for Dissemination and Propagation of B Cell Activation
by: Tanja Stögerer, et al.
Published: (2023-08-01)

Source Tracing of Leishmania donovani in Emerging Foci of Visceral Leishmaniasis, Western Nepal
by: Pieter Monsieurs, et al.
Published: (2024-03-01)

Randomized, double-blind study on intralesional metronidazole versus intralesional sodium stibogluconate in Leishmania donovani cutaneous leishmaniasis
by: Vijani N. Somaratne, et al.
Published: (2019-01-01)

Global genome diversity of the Leishmania donovani complex
by: Susanne U Franssen, et al.
Published: (2020-03-01)

In vitro evaluation, in silico studies and toxicological assay of some xanthones as potential Leishmania donovani inhibitors
by: Marwa S. Osman, et al.
Published: (2022-01-01)

“Immunoinformatic Identification of T-Cell and B-Cell Epitopes From Giardia lamblia Immunogenic Proteins as Candidates to Develop Peptide-Based Vaccines Against Giardiasis”
by: Thania Garzon, et al.
Published: (2021-10-01)

Immunoinformatics Evaluation of a Fusion Protein Composed of Leishmania infantum LiHyV and Phlebotomus kandelakii Apyrase as a Vaccine Candidate against Visceral Leishmaniasis
by: Shima Fayaz, et al.
Published: (2022-05-01)

Polymerase chain reaction detection of LeishmaniaDNA in skin biopsy samples in Sri Lanka where the causative agent of cutaneous leishmaniasis is Leishmania donovani
by: Shalindra Ranasinghe, et al.
Published: (2015-12-01)

Subcellular localization studies of LdBPK_070020, a conserved protein of Leishmania donovani
by: Ruchika Bhardwaj, et al.
Published: (2016-01-01)

Leishmania donovani Infection with Atypical Cutaneous Manifestations, Himachal Pradesh, India, 2014–2018
by: Lovlesh Thakur, et al.
Published: (2020-08-01)

Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in <italic toggle="yes">Leishmania donovani</italic>
by: Eugenia Bifeld, et al.
Published: (2018-10-01)

Leishmania donovani infection in Eastern Sudan: Comparing direct agglutination and rK39 rapid test for diagnosis-a retrospective study
by: Elfadil Abass
Published: (2020-01-01)

Immunoinformatics Studies and Design of a Potential Multi-Epitope Peptide Vaccine to Combat the Fatal Visceral Leishmaniasis
by: Olugbenga Samson Onile, et al.
Published: (2022-09-01)

Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles
by: Alessio Nocentini, et al.
Published: (2018-01-01)

Immunoinformatics Approach for Epitope-Based Vaccine Design: Key Steps for Breast Cancer Vaccine
by: Aisyah Fitriannisa Prawiningrum, et al.
Published: (2022-11-01)

Developing a multiepitope vaccine against dengue virus in Bangladesh using immunoinformatics approach
by: Sajidur Rahman Akash, et al.
Published: (2023-04-01)

A multiepitope vaccine candidate against infectious bursal disease virus using immunoinformatics-based reverse vaccinology approach
by: Irfan Gul, et al.
Published: (2023-01-01)

The first documentation of the immune response to cutaneous leishmaniasis caused by Leishmania donovani in Sri Lanka.
by: D. Atapattu, et al.
Published: (2017-10-01)

Leishmania donovani Growth Inhibitors from Pathogen Box Compounds of Medicine for Malaria Venture
by: Tadele M, et al.
Published: (2020-03-01)

T-cell epitope vaccine design by immunoinformatics
by: Atanas Patronov, et al.
Published: (2013-01-01)

Immunoinformatic analysis of glycoprotein from bovine ephemeral fever virus
by: Mehran Bakhshesh, et al.
Published: (2018-01-01)

Leishmania donovani Transmission Cycle Associated with Human Infection, Phlebotomus alexandri Sand Flies, and Hare Blood Meals, Israel
by: Liora Studentsky, et al.
Published: (2023-05-01)

Rational repurposing, synthesis, in vitro and in silico studies of chromone-peptidyl hybrids as potential agents against Leishmania donovani
by: Ahmed H. E. Hassan, et al.
Published: (2023-12-01)

Leptomonas seymouri Co-infection in Cutaneous Leishmaniasis Cases Caused by Leishmania donovani From Himachal Pradesh, India
by: Lovlesh Thakur, et al.
Published: (2020-07-01)

An Insight for the Future Development of Diagnostic Tool by Exploiting Novel Leishmania Donovani Recombinant Hypothetical Protein
by: Fauzia Jamal, et al.
Published: (2018-11-01)

Leishmania donovani induced increase in macrophage Bcl-2 favors parasite survival
by: Rajeev Kumar Pandey, et al.
Published: (2016-10-01)

Increased amphiregulin expression by CD4+ T cells from individuals with asymptomatic Leishmania donovani infection
by: Siddharth Sankar Singh, et al.
Published: (2022-01-01)

In vitro and in vivo immunomodulatory properties of octyl-β-d-galactofuranoside during Leishmania donovani infection
by: Hélène Guegan, et al.
Published: (2019-12-01)

Discovering conserved epitopes of Monkeypox: Novel immunoinformatic and machine learning approaches
by: Mohammad Izadi, et al.
Published: (2024-02-01)

The FML (Fucose Mannose Ligand) of Leishmania donovani: a new tool in diagnosis, prognosis, transfusional control and vaccination against human kala-azar
by: Claris B. Palatnik de Sousa, et al.
Published: (1996-04-01)

Low prevalence of <it>Leishmania donovani</it> infection among the blood donors in kala-azar endemic areas of Bangladesh
by: Huda M Mamun, et al.
Published: (2013-02-01)