Inflammasomes as Targets for Adjuvants
Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which stimulate the adaptive immune...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/9/4/252 |
| _version_ | 1797571977259515904 |
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| author | Konstantin Ivanov Ekaterina Garanina Albert Rizvanov Svetlana Khaiboullina |
| author_facet | Konstantin Ivanov Ekaterina Garanina Albert Rizvanov Svetlana Khaiboullina |
| author_sort | Konstantin Ivanov |
| collection | DOAJ |
| description | Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which stimulate the adaptive immune system. Inflammasomes activators can be used as adjuvants to provide and maintain the strength of the immune response. This review is focused on the mechanisms of action and the effects of adjuvants on inflammasomes. The therapeutic and prophylaxis significance of inflammasomes in infectious diseases is also discussed. |
| first_indexed | 2024-03-10T20:48:10Z |
| format | Article |
| id | doaj.art-b854317f266749feb2767268fbc0102b |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T20:48:10Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-b854317f266749feb2767268fbc0102b2023-11-19T20:09:35ZengMDPI AGPathogens2076-08172020-03-019425210.3390/pathogens9040252Inflammasomes as Targets for AdjuvantsKonstantin Ivanov0Ekaterina Garanina1Albert Rizvanov2Svetlana Khaiboullina3Kazan Federal University, 420008 Kazan, RussiaKazan Federal University, 420008 Kazan, RussiaKazan Federal University, 420008 Kazan, RussiaKazan Federal University, 420008 Kazan, RussiaInflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which stimulate the adaptive immune system. Inflammasomes activators can be used as adjuvants to provide and maintain the strength of the immune response. This review is focused on the mechanisms of action and the effects of adjuvants on inflammasomes. The therapeutic and prophylaxis significance of inflammasomes in infectious diseases is also discussed.https://www.mdpi.com/2076-0817/9/4/252vaccinesadjuvantsinflammasomesinnate immunitycytokines |
| spellingShingle | Konstantin Ivanov Ekaterina Garanina Albert Rizvanov Svetlana Khaiboullina Inflammasomes as Targets for Adjuvants Pathogens vaccines adjuvants inflammasomes innate immunity cytokines |
| title | Inflammasomes as Targets for Adjuvants |
| title_full | Inflammasomes as Targets for Adjuvants |
| title_fullStr | Inflammasomes as Targets for Adjuvants |
| title_full_unstemmed | Inflammasomes as Targets for Adjuvants |
| title_short | Inflammasomes as Targets for Adjuvants |
| title_sort | inflammasomes as targets for adjuvants |
| topic | vaccines adjuvants inflammasomes innate immunity cytokines |
| url | https://www.mdpi.com/2076-0817/9/4/252 |
| work_keys_str_mv | AT konstantinivanov inflammasomesastargetsforadjuvants AT ekaterinagaranina inflammasomesastargetsforadjuvants AT albertrizvanov inflammasomesastargetsforadjuvants AT svetlanakhaiboullina inflammasomesastargetsforadjuvants |