Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents
Abstract Limited evidence is available regarding the association of methyl donor nutrients and adolescents’ metabolic health. Therefore, we investigated the relation between a combination of methyl donor nutrients and metabolic health status of overweight and obese Iranian adolescents. In this cross...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-21602-9 |
| _version_ | 1828723308247384064 |
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| author | Donya Poursalehi Keyhan Lotfi Saeideh Mirzaei Ali Asadi Masoumeh Akhlaghi Parvane Saneei |
| author_facet | Donya Poursalehi Keyhan Lotfi Saeideh Mirzaei Ali Asadi Masoumeh Akhlaghi Parvane Saneei |
| author_sort | Donya Poursalehi |
| collection | DOAJ |
| description | Abstract Limited evidence is available regarding the association of methyl donor nutrients and adolescents’ metabolic health. Therefore, we investigated the relation between a combination of methyl donor nutrients and metabolic health status of overweight and obese Iranian adolescents. In this cross-sectional study, 203 overweight/obese adolescents were included, using a multistage cluster random-sampling method. Dietary intakes were assessed by a validated food frequency questionnaire. Methyl donor nutrient score (MDNS) was constructed based on deciles of vitamins B2, B6, B9, B12, methionine, choline and betaine. Glycemic profile, lipid profile, blood pressure and anthropometric indices were collected. Participants were classified as metabolically healthy obese or unhealthy obese (MUO) based on International Diabetes Federation (IDF) and IDF/Homeostasis Model Assessment Insulin Resistance (HOMA-IR) definitions. Mean age of adolescents was 13.98 $$\pm$$ ± 1.61 y and 50.2% of them was girls. After controlling all of the confounders, individuals in the top tertile of MDNS, had lower odds of MUO (OR 0.36; 95% CI 0.13–0.95) according to IFD criteria. Considering IDF/HOMA-IR criteria, an inverse marginally significant association was observed between the highest tertile of MDNS and odds of MUO (OR 0.36; 95% CI 0.12–1.02) in the fully-adjusted model. Furthermore, significant inverse association was found between each unit increase in MDNS and odds of MUO based on IDF criteria, but not for IDF/HOMA-IR definition. We found that overweight/obese adolescents with higher dietary intakes of methyl donor nutrients were less likely to be metabolically unhealthy. Further studies are needed to confirm the findings. |
| first_indexed | 2024-04-12T12:47:34Z |
| format | Article |
| id | doaj.art-b854a7ed8e054b67923040f4f58161e4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T12:47:34Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b854a7ed8e054b67923040f4f58161e42022-12-22T03:32:34ZengNature PortfolioScientific Reports2045-23222022-10-0112111010.1038/s41598-022-21602-9Association between methyl donor nutrients and metabolic health status in overweight and obese adolescentsDonya Poursalehi0Keyhan Lotfi1Saeideh Mirzaei2Ali Asadi3Masoumeh Akhlaghi4Parvane Saneei5Students’ Scientific Research Center, Isfahan University of Medical SciencesDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical SciencesDepartment of Exercise Physiology, School of Physical Education and Sport Sciences, University of TehranDepartment of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical SciencesDepartment of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical SciencesAbstract Limited evidence is available regarding the association of methyl donor nutrients and adolescents’ metabolic health. Therefore, we investigated the relation between a combination of methyl donor nutrients and metabolic health status of overweight and obese Iranian adolescents. In this cross-sectional study, 203 overweight/obese adolescents were included, using a multistage cluster random-sampling method. Dietary intakes were assessed by a validated food frequency questionnaire. Methyl donor nutrient score (MDNS) was constructed based on deciles of vitamins B2, B6, B9, B12, methionine, choline and betaine. Glycemic profile, lipid profile, blood pressure and anthropometric indices were collected. Participants were classified as metabolically healthy obese or unhealthy obese (MUO) based on International Diabetes Federation (IDF) and IDF/Homeostasis Model Assessment Insulin Resistance (HOMA-IR) definitions. Mean age of adolescents was 13.98 $$\pm$$ ± 1.61 y and 50.2% of them was girls. After controlling all of the confounders, individuals in the top tertile of MDNS, had lower odds of MUO (OR 0.36; 95% CI 0.13–0.95) according to IFD criteria. Considering IDF/HOMA-IR criteria, an inverse marginally significant association was observed between the highest tertile of MDNS and odds of MUO (OR 0.36; 95% CI 0.12–1.02) in the fully-adjusted model. Furthermore, significant inverse association was found between each unit increase in MDNS and odds of MUO based on IDF criteria, but not for IDF/HOMA-IR definition. We found that overweight/obese adolescents with higher dietary intakes of methyl donor nutrients were less likely to be metabolically unhealthy. Further studies are needed to confirm the findings.https://doi.org/10.1038/s41598-022-21602-9 |
| spellingShingle | Donya Poursalehi Keyhan Lotfi Saeideh Mirzaei Ali Asadi Masoumeh Akhlaghi Parvane Saneei Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents Scientific Reports |
| title | Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents |
| title_full | Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents |
| title_fullStr | Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents |
| title_full_unstemmed | Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents |
| title_short | Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents |
| title_sort | association between methyl donor nutrients and metabolic health status in overweight and obese adolescents |
| url | https://doi.org/10.1038/s41598-022-21602-9 |
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