The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition

The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition

Objective: The minor allele (A) of the rs373863828 variant (p.Arg457Gln) in CREBRF is restricted to indigenous peoples of the Pacific islands (including New Zealand Māori and peoples of Polynesia), with a frequency of up to 25% in these populations. This allele associates with a large increase in bo...

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Bibliographic Details
Main Authors: Kate Lee, Sanaz Vakili, Hannah J. Burden, Shannon Adams, Greg C. Smith, Braydon Kulatea, Morag Wright-McNaughton, Danielle Sword, Conor Watene-O’Sullivan, Robert D. Atiola, Ryan G. Paul, Lindsay D. Plank, Prasanna Kallingappa, Frances King, Phillip Wilcox, Tony R. Merriman, Jeremy D. Krebs, Rosemary M. Hall, Rinki Murphy, Troy L. Merry, Peter R. Shepherd
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Molecular Metabolism
Subjects:
Body mass index
Obesity
Body composition
Genetics
Type-2 diabetes
Myostatin
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822000333

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http://www.sciencedirect.com/science/article/pii/S2212877822000333

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