Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model
Chronic, subclinical inflammation was often observed in the diabetic wound area, causing inadequate and delayed wound-healing effects by failing to initiate cell migration, proliferation, and extracellular matrix deposition. Therefore, we presented macrophage-derived exosomes (Exos) and explored the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1669617 |
| _version_ | 1818008734465523712 |
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| author | Mengdie Li Tao Wang He Tian Guohua Wei Liang Zhao Yijie Shi |
| author_facet | Mengdie Li Tao Wang He Tian Guohua Wei Liang Zhao Yijie Shi |
| author_sort | Mengdie Li |
| collection | DOAJ |
| description | Chronic, subclinical inflammation was often observed in the diabetic wound area, causing inadequate and delayed wound-healing effects by failing to initiate cell migration, proliferation, and extracellular matrix deposition. Therefore, we presented macrophage-derived exosomes (Exos) and explored their potential for inhibiting inflammation and accelerating diabetic wound healing in a skin defect, diabetic rat model. A thorough investigation demonstrated that Exos exerted anti-inflammatory effects by inhibiting the secretion of pro-inflammatory enzymes and cytokines. Furthermore, they accelerated the wound-healing process by inducing endothelial cell proliferation and migration to improve angiogenesis and re-epithelialization in diabetic wounds. |
| first_indexed | 2024-04-14T05:34:00Z |
| format | Article |
| id | doaj.art-b8570f42b40b41d69acac1deda46f140 |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-04-14T05:34:00Z |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-b8570f42b40b41d69acac1deda46f1402022-12-22T02:09:43ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2019-12-014713793380310.1080/21691401.2019.1669617Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat modelMengdie Li0Tao Wang1He Tian2Guohua Wei3Liang Zhao4Yijie Shi5School of Pharmacy, Jinzhou Medical University, Jinzhou, P R ChinaSchool of Pharmacy, Jinzhou Medical University, Jinzhou, P R ChinaDepartment of Histology and Embryology, Jinzhou Medical University, Jinzhou, P R ChinaDepartment of Pathology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, P R ChinaSchool of Pharmacy, Jinzhou Medical University, Jinzhou, P R ChinaSchool of Pharmacy, Jinzhou Medical University, Jinzhou, P R ChinaChronic, subclinical inflammation was often observed in the diabetic wound area, causing inadequate and delayed wound-healing effects by failing to initiate cell migration, proliferation, and extracellular matrix deposition. Therefore, we presented macrophage-derived exosomes (Exos) and explored their potential for inhibiting inflammation and accelerating diabetic wound healing in a skin defect, diabetic rat model. A thorough investigation demonstrated that Exos exerted anti-inflammatory effects by inhibiting the secretion of pro-inflammatory enzymes and cytokines. Furthermore, they accelerated the wound-healing process by inducing endothelial cell proliferation and migration to improve angiogenesis and re-epithelialization in diabetic wounds.https://www.tandfonline.com/doi/10.1080/21691401.2019.1669617Diabetesinflammationwound healingexosomesangiogenesis |
| spellingShingle | Mengdie Li Tao Wang He Tian Guohua Wei Liang Zhao Yijie Shi Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model Artificial Cells, Nanomedicine, and Biotechnology Diabetes inflammation wound healing exosomes angiogenesis |
| title | Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model |
| title_full | Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model |
| title_fullStr | Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model |
| title_full_unstemmed | Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model |
| title_short | Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model |
| title_sort | macrophage derived exosomes accelerate wound healing through their anti inflammation effects in a diabetic rat model |
| topic | Diabetes inflammation wound healing exosomes angiogenesis |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1669617 |
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