Sustainable and selective synthesis of benzimidazole scaffolds using deep eutectic solvents

Sustainable and selective synthesis of benzimidazole scaffolds using deep eutectic solvents

In the present article, the catalytic activity of Zr based DESs (DES 1-DES 3) and Ce based DESs (DES 4-DES 7) was compared for the synthesis of benzimidazole derivatives. Among the seven DESs, excellent conversion was observed for DES 1 (formed from ZrOCl2·8H2O and urea at 1:5 ratio). This might be...

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Bibliographic Details
Main Authors: M. Shaibuna, K. Hiba, A.M. Shebitha, Muhammed Jeneesh Kariyottu Kuniyil, P.B. Sherly mole, K. Sreekumar
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Green and Sustainable Chemistry
Subjects:
Deep eutectic solvents
Recyclable catalyst
Benzimidazole synthesis
Substituent effect
Online Access:http://www.sciencedirect.com/science/article/pii/S2666086522000273
Description
Summary:In the present article, the catalytic activity of Zr based DESs (DES 1-DES 3) and Ce based DESs (DES 4-DES 7) was compared for the synthesis of benzimidazole derivatives. Among the seven DESs, excellent conversion was observed for DES 1 (formed from ZrOCl2·8H2O and urea at 1:5 ratio). This might be due to the higher acidity and lower viscosity of DES 1 compared to others. The present method was found to be efficient for the synthesis of 2-substituted benzimidazoles with interesting characteristics such as easy preparation of the catalyst, high product yield, simple reaction procedure and the reusability of the catalyst. It is for the first time, a recyclable and selective protocol for the synthesis of benzimidazoles using deep eutectic solvent was reported.
ISSN:2666-0865

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