The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury
Ischemia-reperfusion injury (IRI) is considered an inherent component involved in liver transplantation, which induce early organ dysfunction and failure. And the accumulating evidences indicate that the activation of host innate immune system, especially hepatic macrophages, play a pivotal role in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.905423/full |
| _version_ | 1818471036914499584 |
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| author | Tong Wu Cheng Zhang Tianfeng Shao Jianzhong Chen Diyu Chen |
| author_facet | Tong Wu Cheng Zhang Tianfeng Shao Jianzhong Chen Diyu Chen |
| author_sort | Tong Wu |
| collection | DOAJ |
| description | Ischemia-reperfusion injury (IRI) is considered an inherent component involved in liver transplantation, which induce early organ dysfunction and failure. And the accumulating evidences indicate that the activation of host innate immune system, especially hepatic macrophages, play a pivotal role in the progression of LIRI. Inflammasomes is a kind of intracellular multimolecular complexes that actively participate in the innate immune responses and proinflammatory signaling pathways. Among them, NLRP3 inflammasome is the best characterized and correspond to regulate caspase-1 activation and the secretion of proinflammatory cytokines in response to various pathogen-derived as well as danger-associated signals. Additionally, NLRP3 is highly expressed in hepatic macrophages, and the assembly of NLRP3 inflammasome could lead to LIRI, which makes it a promising therapeutic target. However, detailed mechanisms about NLRP3 inflammasome involving in the hepatic macrophages-related LIRI is rarely summarized. Here, we review the potential role of the NLRP3 inflammasome pathway of hepatic macrophages in LIRI, with highlights on currently available therapeutic options. |
| first_indexed | 2024-04-13T21:45:41Z |
| format | Article |
| id | doaj.art-b85ab429134d408d87b5af7db2a15e25 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T21:45:41Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b85ab429134d408d87b5af7db2a15e252022-12-22T02:28:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-06-011310.3389/fimmu.2022.905423905423The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion InjuryTong Wu0Cheng Zhang1Tianfeng Shao2Jianzhong Chen3Diyu Chen4School of Medicine, Zhejiang University, Hangzhou, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of General Practice, Shaoxing Yuecheng District Tashan Street Community Health Service Center, Shaoxing, ChinaInstitute of Immunology, School of Medicine, Zhejiang University, Hangzhou, ChinaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaIschemia-reperfusion injury (IRI) is considered an inherent component involved in liver transplantation, which induce early organ dysfunction and failure. And the accumulating evidences indicate that the activation of host innate immune system, especially hepatic macrophages, play a pivotal role in the progression of LIRI. Inflammasomes is a kind of intracellular multimolecular complexes that actively participate in the innate immune responses and proinflammatory signaling pathways. Among them, NLRP3 inflammasome is the best characterized and correspond to regulate caspase-1 activation and the secretion of proinflammatory cytokines in response to various pathogen-derived as well as danger-associated signals. Additionally, NLRP3 is highly expressed in hepatic macrophages, and the assembly of NLRP3 inflammasome could lead to LIRI, which makes it a promising therapeutic target. However, detailed mechanisms about NLRP3 inflammasome involving in the hepatic macrophages-related LIRI is rarely summarized. Here, we review the potential role of the NLRP3 inflammasome pathway of hepatic macrophages in LIRI, with highlights on currently available therapeutic options.https://www.frontiersin.org/articles/10.3389/fimmu.2022.905423/fullinflammasomeNLRP3ischemia reperfusion injuryhepatic macrophageliver transplantation |
| spellingShingle | Tong Wu Cheng Zhang Tianfeng Shao Jianzhong Chen Diyu Chen The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury Frontiers in Immunology inflammasome NLRP3 ischemia reperfusion injury hepatic macrophage liver transplantation |
| title | The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury |
| title_full | The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury |
| title_fullStr | The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury |
| title_full_unstemmed | The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury |
| title_short | The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury |
| title_sort | role of nlrp3 inflammasome activation pathway of hepatic macrophages in liver ischemia reperfusion injury |
| topic | inflammasome NLRP3 ischemia reperfusion injury hepatic macrophage liver transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.905423/full |
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