Prognostic value of optical flow ratio for cardiovascular outcomes in patients after percutaneous coronary stent implantation
BackgroundThe relationship between the optical flow ratio (OFR) and clinical outcomes in patients with coronary artery disease (CAD) after percutaneous coronary stent implantation (PCI) remains unknown.ObjectiveTo examine the correlation between post-PCI OFR and clinical outcomes in patients with CA...
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| Format: | Article |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1247053/full |
| _version_ | 1827589559932682240 |
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| author | Tianyu Hu Qinghua Qiu Nianjin Xie Mingming Sun Qianjun Jia Meiping Huang |
| author_facet | Tianyu Hu Qinghua Qiu Nianjin Xie Mingming Sun Qianjun Jia Meiping Huang |
| author_sort | Tianyu Hu |
| collection | DOAJ |
| description | BackgroundThe relationship between the optical flow ratio (OFR) and clinical outcomes in patients with coronary artery disease (CAD) after percutaneous coronary stent implantation (PCI) remains unknown.ObjectiveTo examine the correlation between post-PCI OFR and clinical outcomes in patients with CAD following PCI.MethodsPatients who underwent optical coherence tomography (OCT) guided PCI at Guangdong Provincial People's Hospital were retrospectively and continuously enrolled. Clinical data, post-PCI OCT characteristics, and OFR measurements were collected and analyzed to identify predictors of target vessel failure (TVF) after PCI.ResultsAmong 354 enrolled patients, 26 suffered TVF during a median follow-up of 484 (IQR: 400–774) days. Post-PCI OFR was significantly lower in the TVF group than in the non-TVF group (0.89 vs. 0.93; P = 0.001). In multivariable Cox regression analysis, post-PCI OFR (HR per 0.1 increase: 0.60; 95% CI: 0.41–0.89; P = 0.011), large stent edge dissection (HR: 3.85; 95% CI: 1.51–9.84; P = 0.005) and thin-cap fibroatheroma (TCFA) (HR: 2.95; 95% CI: 1.19–7.35; P = 0.020) in the non-stented segment were independently associated with TVF. In addition, the inclusion of post-PCI OFR to baseline characteristics and post-PCI OCT findings improved the predictive power of the model to distinguish subsequent TVF after PCI (0.838 vs. 0.796; P = 0.028).ConclusionThe post-PCI OFR serves as an independent determinant of risk for TVF in individuals with CAD after PCI. The inclusion of post-PCI OFR assessments, alongside baseline characteristics and post-PCI OCT findings, substantially enhances the capacity to differentiate the subsequent manifestation of TVF in CAD patients following PCI. |
| first_indexed | 2024-03-09T01:04:02Z |
| format | Article |
| id | doaj.art-b85d9f3f28ac4db6beaa11e743a873e7 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-09T01:04:02Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b85d9f3f28ac4db6beaa11e743a873e72023-12-11T14:07:40ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-12-011010.3389/fcvm.2023.12470531247053Prognostic value of optical flow ratio for cardiovascular outcomes in patients after percutaneous coronary stent implantationTianyu Hu0Qinghua Qiu1Nianjin Xie2Mingming Sun3Qianjun Jia4Meiping Huang5Department of Catheterization Lab, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, ChinaDepartment of Catheterization Lab, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, ChinaDepartment of Catheterization Lab, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, ChinaDepartment of Catheterization Lab, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, ChinaDepartment of Catheterization Lab, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, ChinaBackgroundThe relationship between the optical flow ratio (OFR) and clinical outcomes in patients with coronary artery disease (CAD) after percutaneous coronary stent implantation (PCI) remains unknown.ObjectiveTo examine the correlation between post-PCI OFR and clinical outcomes in patients with CAD following PCI.MethodsPatients who underwent optical coherence tomography (OCT) guided PCI at Guangdong Provincial People's Hospital were retrospectively and continuously enrolled. Clinical data, post-PCI OCT characteristics, and OFR measurements were collected and analyzed to identify predictors of target vessel failure (TVF) after PCI.ResultsAmong 354 enrolled patients, 26 suffered TVF during a median follow-up of 484 (IQR: 400–774) days. Post-PCI OFR was significantly lower in the TVF group than in the non-TVF group (0.89 vs. 0.93; P = 0.001). In multivariable Cox regression analysis, post-PCI OFR (HR per 0.1 increase: 0.60; 95% CI: 0.41–0.89; P = 0.011), large stent edge dissection (HR: 3.85; 95% CI: 1.51–9.84; P = 0.005) and thin-cap fibroatheroma (TCFA) (HR: 2.95; 95% CI: 1.19–7.35; P = 0.020) in the non-stented segment were independently associated with TVF. In addition, the inclusion of post-PCI OFR to baseline characteristics and post-PCI OCT findings improved the predictive power of the model to distinguish subsequent TVF after PCI (0.838 vs. 0.796; P = 0.028).ConclusionThe post-PCI OFR serves as an independent determinant of risk for TVF in individuals with CAD after PCI. The inclusion of post-PCI OFR assessments, alongside baseline characteristics and post-PCI OCT findings, substantially enhances the capacity to differentiate the subsequent manifestation of TVF in CAD patients following PCI.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1247053/fullcoronary artery diseaseoptical coherence tomographyoptical flow ratiopercutaneous coronary stent implantationtarget vessel failure |
| spellingShingle | Tianyu Hu Qinghua Qiu Nianjin Xie Mingming Sun Qianjun Jia Meiping Huang Prognostic value of optical flow ratio for cardiovascular outcomes in patients after percutaneous coronary stent implantation Frontiers in Cardiovascular Medicine coronary artery disease optical coherence tomography optical flow ratio percutaneous coronary stent implantation target vessel failure |
| title | Prognostic value of optical flow ratio for cardiovascular outcomes in patients after percutaneous coronary stent implantation |
| title_full | Prognostic value of optical flow ratio for cardiovascular outcomes in patients after percutaneous coronary stent implantation |
| title_fullStr | Prognostic value of optical flow ratio for cardiovascular outcomes in patients after percutaneous coronary stent implantation |
| title_full_unstemmed | Prognostic value of optical flow ratio for cardiovascular outcomes in patients after percutaneous coronary stent implantation |
| title_short | Prognostic value of optical flow ratio for cardiovascular outcomes in patients after percutaneous coronary stent implantation |
| title_sort | prognostic value of optical flow ratio for cardiovascular outcomes in patients after percutaneous coronary stent implantation |
| topic | coronary artery disease optical coherence tomography optical flow ratio percutaneous coronary stent implantation target vessel failure |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1247053/full |
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