A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols

A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols

ABSTRACT Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However, FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making FLC fungicidal in combination with adjuvants is a promising strategy to avoid FLC resistance and eliminat...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Hui Lu, Wanqian Li, Malcolm Whiteway, Hongkang Wang, Shuo Zhu, Zhe Ji, Yanru Feng, Lan Yan, Ting Fang, Liping Li, Tingjunhong Ni, Xiaolong Zhang, Quanzhen Lv, Zichao Ding, Lijuan Qiu, Dazhi Zhang, Yuanying Jiang
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: American Society for Microbiology 2023-02-01
Σειρά:mBio
Θέματα:
fluconazole tolerance
Erg251
small molecule inhibitor
fluconazole adjuvant
Candida albicans
Διαθέσιμο Online:https://journals.asm.org/doi/10.1128/mbio.02639-22

Διαδίκτυο

https://journals.asm.org/doi/10.1128/mbio.02639-22

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