p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs
Normal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and expansion to promote liver tu...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16616-8 |
| _version_ | 1828972445809246208 |
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| author | Hye Yeon Choi Hifzur R. Siddique Mengmei Zheng Yi Kou Da-Wei Yeh Tatsuya Machida Chia-Lin Chen Dinesh Babu Uthaya Kumar Vasu Punj Peleg Winer Alejandro Pita Linda Sher Stanley M. Tahara Ratna B. Ray Chengyu Liang Lin Chen Hidekazu Tsukamoto Keigo Machida |
| author_facet | Hye Yeon Choi Hifzur R. Siddique Mengmei Zheng Yi Kou Da-Wei Yeh Tatsuya Machida Chia-Lin Chen Dinesh Babu Uthaya Kumar Vasu Punj Peleg Winer Alejandro Pita Linda Sher Stanley M. Tahara Ratna B. Ray Chengyu Liang Lin Chen Hidekazu Tsukamoto Keigo Machida |
| author_sort | Hye Yeon Choi |
| collection | DOAJ |
| description | Normal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and expansion to promote liver tumorigenesis. |
| first_indexed | 2024-12-14T13:28:15Z |
| format | Article |
| id | doaj.art-b860fba9de8448de8c15f0811ec7cae9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:28:15Z |
| publishDate | 2020-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b860fba9de8448de8c15f0811ec7cae92022-12-21T22:59:46ZengNature PortfolioNature Communications2041-17232020-06-0111111610.1038/s41467-020-16616-8p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICsHye Yeon Choi0Hifzur R. Siddique1Mengmei Zheng2Yi Kou3Da-Wei Yeh4Tatsuya Machida5Chia-Lin Chen6Dinesh Babu Uthaya Kumar7Vasu Punj8Peleg Winer9Alejandro Pita10Linda Sher11Stanley M. Tahara12Ratna B. Ray13Chengyu Liang14Lin Chen15Hidekazu Tsukamoto16Keigo Machida17Department of Molecular Microbiology and Immunology, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaDepartment of Chemistry and Biological Sciences, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaDepartment of Medicine, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaDepartment of Surgery, University of Southern CaliforniaDepartment of Surgery, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaSaint Louis UniversityDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaDepartment of Chemistry and Biological Sciences, University of Southern CaliforniaDepartment of Pathology, Keck School of Medicine, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaNormal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and expansion to promote liver tumorigenesis.https://doi.org/10.1038/s41467-020-16616-8 |
| spellingShingle | Hye Yeon Choi Hifzur R. Siddique Mengmei Zheng Yi Kou Da-Wei Yeh Tatsuya Machida Chia-Lin Chen Dinesh Babu Uthaya Kumar Vasu Punj Peleg Winer Alejandro Pita Linda Sher Stanley M. Tahara Ratna B. Ray Chengyu Liang Lin Chen Hidekazu Tsukamoto Keigo Machida p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs Nature Communications |
| title | p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs |
| title_full | p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs |
| title_fullStr | p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs |
| title_full_unstemmed | p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs |
| title_short | p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs |
| title_sort | p53 destabilizing protein skews asymmetric division and enhances notch activation to direct self renewal of tics |
| url | https://doi.org/10.1038/s41467-020-16616-8 |
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