SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes

SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes

Abstract Background Prognosis of esophageal squamous cell carcinoma (ESCC) patients is poor and the concurrent chemoradiation therapy (CCRT) provided to ESCC patients often failed due to resistance. Therefore, development of biomarkers for predicting CCRT response is immensely important. In this stu...

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Bibliographic Details
Main Authors: I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai, Yi-Ching Wang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Biomedical Science
Subjects:
SOX17
Transcription regulation
Resistance
DNA repair
Concurrent chemoradiation therapy
Esophageal cancer
Online Access:http://link.springer.com/article/10.1186/s12929-019-0510-4

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