Design, Synthesis and Biological Evaluation of Jahanyne Analogs as Cell Cycle Arrest Inducers
Jahanyne, a lipopeptide with a unique terminal alkynyl and OEP (2-(1-oxo-ethyl)-pyrrolidine) moiety, exhibits anticancer activity. We synthesized jahanyne and analogs modified at the OEP moiety, employing an α-fluoromethyl ketone (FMK) strategy. Preliminary bioassays indicated that compound...
Main Authors: | Baijun Ye, Jianmiao Gong, Qiuying Li, Shiqi Bao, Xuemei Zhang, Jing Chen, Qing Meng, Bolin Chen, Peng Jiang, Liang Wang, Yue Chen |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-03-01
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Series: | Marine Drugs |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-3397/18/3/176 |
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