A micellar on-pathway intermediate step explains the kinetics of prion amyloid formation.
In a previous work by Alvarez-Martinez et al. (2011), the authors pointed out some fallacies in the mainstream interpretation of the prion amyloid formation. It appeared necessary to propose an original hypothesis able to reconcile the in vitro data with the predictions of a mathematical model descr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-08-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC4125056?pdf=render |
| _version_ | 1811269825202225152 |
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| author | Erwan Hingant Pascaline Fontes Maria Teresa Alvarez-Martinez Jacques-Damien Arnaud Jean-Pierre Liautard Laurent Pujo-Menjouet |
| author_facet | Erwan Hingant Pascaline Fontes Maria Teresa Alvarez-Martinez Jacques-Damien Arnaud Jean-Pierre Liautard Laurent Pujo-Menjouet |
| author_sort | Erwan Hingant |
| collection | DOAJ |
| description | In a previous work by Alvarez-Martinez et al. (2011), the authors pointed out some fallacies in the mainstream interpretation of the prion amyloid formation. It appeared necessary to propose an original hypothesis able to reconcile the in vitro data with the predictions of a mathematical model describing the problem. Here, a model is developed accordingly with the hypothesis that an intermediate on-pathway leads to the conformation of the prion protein into an amyloid competent isoform thanks to a structure, called micelles, formed from hydrodynamic interaction. The authors also compare data to the prediction of their model and propose a new hypothesis for the formation of infectious prion amyloids. |
| first_indexed | 2024-04-12T21:48:57Z |
| format | Article |
| id | doaj.art-b865c0f123a84a3097055e648c76773d |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-04-12T21:48:57Z |
| publishDate | 2014-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-b865c0f123a84a3097055e648c76773d2022-12-22T03:15:32ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582014-08-01108e100373510.1371/journal.pcbi.1003735A micellar on-pathway intermediate step explains the kinetics of prion amyloid formation.Erwan HingantPascaline FontesMaria Teresa Alvarez-MartinezJacques-Damien ArnaudJean-Pierre LiautardLaurent Pujo-MenjouetIn a previous work by Alvarez-Martinez et al. (2011), the authors pointed out some fallacies in the mainstream interpretation of the prion amyloid formation. It appeared necessary to propose an original hypothesis able to reconcile the in vitro data with the predictions of a mathematical model describing the problem. Here, a model is developed accordingly with the hypothesis that an intermediate on-pathway leads to the conformation of the prion protein into an amyloid competent isoform thanks to a structure, called micelles, formed from hydrodynamic interaction. The authors also compare data to the prediction of their model and propose a new hypothesis for the formation of infectious prion amyloids.http://europepmc.org/articles/PMC4125056?pdf=render |
| spellingShingle | Erwan Hingant Pascaline Fontes Maria Teresa Alvarez-Martinez Jacques-Damien Arnaud Jean-Pierre Liautard Laurent Pujo-Menjouet A micellar on-pathway intermediate step explains the kinetics of prion amyloid formation. PLoS Computational Biology |
| title | A micellar on-pathway intermediate step explains the kinetics of prion amyloid formation. |
| title_full | A micellar on-pathway intermediate step explains the kinetics of prion amyloid formation. |
| title_fullStr | A micellar on-pathway intermediate step explains the kinetics of prion amyloid formation. |
| title_full_unstemmed | A micellar on-pathway intermediate step explains the kinetics of prion amyloid formation. |
| title_short | A micellar on-pathway intermediate step explains the kinetics of prion amyloid formation. |
| title_sort | micellar on pathway intermediate step explains the kinetics of prion amyloid formation |
| url | http://europepmc.org/articles/PMC4125056?pdf=render |
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