Geriatric nutritional risk index predicts all-cause mortality in the oldest-old patients with acute coronary syndrome: A 10-year cohort study
Background and objectiveNutritional status assessment in acute coronary syndrome (ACS) patients has been neglected for a long time. The geriatric nutritional risk index (GNRI) is a sensitive indicator for assessing the nutritional status of the elderly. This study aims to explore the association bet...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1129978/full |
| _version_ | 1811159001688178688 |
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| author | Ying Li Ying Li Jian Shen Jian Shen Xiaoling Hou Yongkang Su Yang Jiao Yang Jiao Jihang Wang Jihang Wang Henan Liu Henan Liu Zhenhong Fu Zhenhong Fu |
| author_facet | Ying Li Ying Li Jian Shen Jian Shen Xiaoling Hou Yongkang Su Yang Jiao Yang Jiao Jihang Wang Jihang Wang Henan Liu Henan Liu Zhenhong Fu Zhenhong Fu |
| author_sort | Ying Li |
| collection | DOAJ |
| description | Background and objectiveNutritional status assessment in acute coronary syndrome (ACS) patients has been neglected for a long time. The geriatric nutritional risk index (GNRI) is a sensitive indicator for assessing the nutritional status of the elderly. This study aims to explore the association between GNRI and all-cause mortality in the oldest-old patients with ACS.MethodsThe patients who met the inclusion criteria were consecutively enrolled from January 2006 to December 2012. Clinical data were collected on admission, and all subjects were followed after being discharged. The nutritional status was evaluated using GNRI. The relationship between GNRI and all-cause mortality was assessed by using different analyses.ResultsA total of 662 patients with a mean age of 81.87 ± 2.14 years old were included in our study, and followed (median: 63 months, IQR 51–71). Patients whose GNRI ≤ 98 were reported as at risk of malnutrition (31.11%, n = 206). In multivariable analysis, we found that for each SD increase in GNRI, the risk of all-cause mortality lowered by 23%, and the HR for GNRI ≤ 98 was 1.39 (95% CI 1.04–1.86). After stratifying patients into three groups by tertiles of GNRI, we found that the HRs for tertile 2 and tertile 3 were 1.49 (95% CI 1.02–2.19) and 1.74 (95% CI 1.22–2.50), respectively. The trend test revealed a dose–response relationship between GNRI and all-cause mortality in the oldest-old with ACS. Lastly, in subgroup analyses, we found a reliable association between GNRI and all-cause mortality.ConclusionMalnutrition is common in the oldest-old patients with ACS, and GNRI could predict their long-term all-cause mortality in a dose-dependent manner. GNRI may be a prospective index for risk-stratification and secondary-prevention in the oldest-old patients with ACS. |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T05:33:46Z |
| publishDate | 2023-03-01 |
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| spelling | doaj.art-b865fb89bc614663828a85e1c1844da02023-03-07T05:14:24ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-03-011010.3389/fnut.2023.11299781129978Geriatric nutritional risk index predicts all-cause mortality in the oldest-old patients with acute coronary syndrome: A 10-year cohort studyYing Li0Ying Li1Jian Shen2Jian Shen3Xiaoling Hou4Yongkang Su5Yang Jiao6Yang Jiao7Jihang Wang8Jihang Wang9Henan Liu10Henan Liu11Zhenhong Fu12Zhenhong Fu13Senior Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, ChinaChinese PLA Medical School, Beijing, ChinaSenior Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, ChinaChinese PLA Medical School, Beijing, ChinaSenior Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, ChinaChinese PLA Medical School, Beijing, ChinaSenior Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, ChinaChinese PLA Medical School, Beijing, ChinaChinese PLA Medical School, Beijing, ChinaDepartment of Cardiology, Hainan Hospital, Chinese PLA General Hospital, Sanya, ChinaSenior Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, ChinaChinese PLA Medical School, Beijing, ChinaSenior Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, ChinaChinese PLA Medical School, Beijing, ChinaBackground and objectiveNutritional status assessment in acute coronary syndrome (ACS) patients has been neglected for a long time. The geriatric nutritional risk index (GNRI) is a sensitive indicator for assessing the nutritional status of the elderly. This study aims to explore the association between GNRI and all-cause mortality in the oldest-old patients with ACS.MethodsThe patients who met the inclusion criteria were consecutively enrolled from January 2006 to December 2012. Clinical data were collected on admission, and all subjects were followed after being discharged. The nutritional status was evaluated using GNRI. The relationship between GNRI and all-cause mortality was assessed by using different analyses.ResultsA total of 662 patients with a mean age of 81.87 ± 2.14 years old were included in our study, and followed (median: 63 months, IQR 51–71). Patients whose GNRI ≤ 98 were reported as at risk of malnutrition (31.11%, n = 206). In multivariable analysis, we found that for each SD increase in GNRI, the risk of all-cause mortality lowered by 23%, and the HR for GNRI ≤ 98 was 1.39 (95% CI 1.04–1.86). After stratifying patients into three groups by tertiles of GNRI, we found that the HRs for tertile 2 and tertile 3 were 1.49 (95% CI 1.02–2.19) and 1.74 (95% CI 1.22–2.50), respectively. The trend test revealed a dose–response relationship between GNRI and all-cause mortality in the oldest-old with ACS. Lastly, in subgroup analyses, we found a reliable association between GNRI and all-cause mortality.ConclusionMalnutrition is common in the oldest-old patients with ACS, and GNRI could predict their long-term all-cause mortality in a dose-dependent manner. GNRI may be a prospective index for risk-stratification and secondary-prevention in the oldest-old patients with ACS.https://www.frontiersin.org/articles/10.3389/fnut.2023.1129978/fulloldest oldacute coronary syndromemalnutritionGNRImortality |
| spellingShingle | Ying Li Ying Li Jian Shen Jian Shen Xiaoling Hou Yongkang Su Yang Jiao Yang Jiao Jihang Wang Jihang Wang Henan Liu Henan Liu Zhenhong Fu Zhenhong Fu Geriatric nutritional risk index predicts all-cause mortality in the oldest-old patients with acute coronary syndrome: A 10-year cohort study Frontiers in Nutrition oldest old acute coronary syndrome malnutrition GNRI mortality |
| title | Geriatric nutritional risk index predicts all-cause mortality in the oldest-old patients with acute coronary syndrome: A 10-year cohort study |
| title_full | Geriatric nutritional risk index predicts all-cause mortality in the oldest-old patients with acute coronary syndrome: A 10-year cohort study |
| title_fullStr | Geriatric nutritional risk index predicts all-cause mortality in the oldest-old patients with acute coronary syndrome: A 10-year cohort study |
| title_full_unstemmed | Geriatric nutritional risk index predicts all-cause mortality in the oldest-old patients with acute coronary syndrome: A 10-year cohort study |
| title_short | Geriatric nutritional risk index predicts all-cause mortality in the oldest-old patients with acute coronary syndrome: A 10-year cohort study |
| title_sort | geriatric nutritional risk index predicts all cause mortality in the oldest old patients with acute coronary syndrome a 10 year cohort study |
| topic | oldest old acute coronary syndrome malnutrition GNRI mortality |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1129978/full |
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