IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS
Mesenchymal stromal or stem cells (MSC) represent a population of primitive fibroblastlike cells that are able to differentiate into cellular lineages of connective tissue (osteocytes, chondrocytes, adipocytes), skeletal muscles, and blood vessels. The review deals with contemporary views concerning...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-08-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/677 |
| _version_ | 1797198041911918592 |
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| author | V. B. Klimovich |
| author_facet | V. B. Klimovich |
| author_sort | V. B. Klimovich |
| collection | DOAJ |
| description | Mesenchymal stromal or stem cells (MSC) represent a population of primitive fibroblastlike cells that are able to differentiate into cellular lineages of connective tissue (osteocytes, chondrocytes, adipocytes), skeletal muscles, and blood vessels. The review deals with contemporary views concerning descent, immunophenotype and immunogenicity of MSC. The studies over last decade revealed an ability of MSC to function as immunomodulatory populations which may suppress innate immunity factors (dendritic cells, natural killers, complement), as well as T-helpers and cytotoxic T-lymphocytes, along with activation of regulatory T lymphocytes (Treg). Special attention is given to analysis of conflicting data about influence of MSC on functions of B-lymphocytes and plasma cells in experimental settings, both in vitro and in vivo conditions. Data presently available are insufficient to explain the controversions revealed. In future investigations, it is necessary to consider attribution of B-cells to B1a, B1b, or B2 subpopulations as well as possible presence of poorly studied regulatory B-cells. It is also important also to take into account potential heterogeneity of initial MSC populations being isolated according to previously approved protocols. (Med. Immunol., 2014, vol. 16, N 2, pp 107-126) |
| first_indexed | 2024-03-08T05:50:02Z |
| format | Article |
| id | doaj.art-b86856e30d5846bdb08cc4c250524e5c |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:34Z |
| publishDate | 2014-08-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-b86856e30d5846bdb08cc4c250524e5c2024-04-22T13:07:39ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-08-0116210712610.15789/1563-0625-2014-2-107-126674IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLSV. B. Klimovich0Russian Research Center for Radiology and Surgical Technologies, Ministry of Health Care, St. PetersburgMesenchymal stromal or stem cells (MSC) represent a population of primitive fibroblastlike cells that are able to differentiate into cellular lineages of connective tissue (osteocytes, chondrocytes, adipocytes), skeletal muscles, and blood vessels. The review deals with contemporary views concerning descent, immunophenotype and immunogenicity of MSC. The studies over last decade revealed an ability of MSC to function as immunomodulatory populations which may suppress innate immunity factors (dendritic cells, natural killers, complement), as well as T-helpers and cytotoxic T-lymphocytes, along with activation of regulatory T lymphocytes (Treg). Special attention is given to analysis of conflicting data about influence of MSC on functions of B-lymphocytes and plasma cells in experimental settings, both in vitro and in vivo conditions. Data presently available are insufficient to explain the controversions revealed. In future investigations, it is necessary to consider attribution of B-cells to B1a, B1b, or B2 subpopulations as well as possible presence of poorly studied regulatory B-cells. It is also important also to take into account potential heterogeneity of initial MSC populations being isolated according to previously approved protocols. (Med. Immunol., 2014, vol. 16, N 2, pp 107-126)https://www.mimmun.ru/mimmun/article/view/677mesenchymal stem cellsimmunomodulationcellular therapy |
| spellingShingle | V. B. Klimovich IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS Медицинская иммунология mesenchymal stem cells immunomodulation cellular therapy |
| title | IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS |
| title_full | IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS |
| title_fullStr | IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS |
| title_full_unstemmed | IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS |
| title_short | IMMUNOMODULATORY ACTIVITY OF MESENCHIMAL STROMAL (STEM) CELLS |
| title_sort | immunomodulatory activity of mesenchimal stromal stem cells |
| topic | mesenchymal stem cells immunomodulation cellular therapy |
| url | https://www.mimmun.ru/mimmun/article/view/677 |
| work_keys_str_mv | AT vbklimovich immunomodulatoryactivityofmesenchimalstromalstemcells |