Molecular targets of pomegranate (Punica granatum) in preventing cancer metastasis
Metastasis is the primary cause of mortality and morbidity among cancer patients and accounts for about 90% of cancer deaths. The most common types of treatment for cancer metastasis are chemotherapy and radiotherapy. However, such therapy has many serious side effects that could diminish the qualit...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-09-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | http://ijbms.mums.ac.ir/article_13550_a5f09726edfbd03dabedbbf690457a8a.pdf |
| _version_ | 1818326740096778240 |
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| author | Naghmeh Ahmadiankia |
| author_facet | Naghmeh Ahmadiankia |
| author_sort | Naghmeh Ahmadiankia |
| collection | DOAJ |
| description | Metastasis is the primary cause of mortality and morbidity among cancer patients and accounts for about 90% of cancer deaths. The most common types of treatment for cancer metastasis are chemotherapy and radiotherapy. However, such therapy has many serious side effects that could diminish the quality of life in patients. There is increased appreciation by the scientific community that natural compounds can be potential weapons in fighting against cancer. Interestingly, much evidence shows that pomegranate (Punica granatum) has great potential to inhibit tumor growth and metastasis. In this review, we discussed the molecular targets of pomegranate, specifically, those that are prerequisite for cancer metastasis. The search was performed in Google Scholar, Medline, Scopus, and PubMed using keywords such as metastasis, pomegranate, and signaling pathways. Some of the most important papers from the search results were included. Based on recent studies, some molecules, including those involved in cell-cell and cell-extracellular matrix adhesions, are affected by pomegranate. The other targets of pomegranate are modulators of cytoskeleton dynamics and regulators of cancer cell anoikis and chemotaxis. Furthermore, the antimetastatic effect of pomegranate may be attributed to molecular changes of the extracellular matrix. Pro-inflammatory and pro-angiogenic molecules are the other targets of pomegranate regarding cancer metastasis. A wide variety of molecules can be targeted by pomegranate to suppress tumor metastasis. A better understanding of the molecules regulated by pomegranate is needed to provide a rational basis for its clinical application. |
| first_indexed | 2024-12-13T12:05:10Z |
| format | Article |
| id | doaj.art-b868b53b1a80470fb322c60188c1033c |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-13T12:05:10Z |
| publishDate | 2019-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-b868b53b1a80470fb322c60188c1033c2022-12-21T23:46:59ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742019-09-0122997798810.22038/ijbms.2019.34653.821713550Molecular targets of pomegranate (Punica granatum) in preventing cancer metastasisNaghmeh Ahmadiankia0Cancer Prevention Research Center, Shahroud University of Medical Sciences, Shahroud, IranMetastasis is the primary cause of mortality and morbidity among cancer patients and accounts for about 90% of cancer deaths. The most common types of treatment for cancer metastasis are chemotherapy and radiotherapy. However, such therapy has many serious side effects that could diminish the quality of life in patients. There is increased appreciation by the scientific community that natural compounds can be potential weapons in fighting against cancer. Interestingly, much evidence shows that pomegranate (Punica granatum) has great potential to inhibit tumor growth and metastasis. In this review, we discussed the molecular targets of pomegranate, specifically, those that are prerequisite for cancer metastasis. The search was performed in Google Scholar, Medline, Scopus, and PubMed using keywords such as metastasis, pomegranate, and signaling pathways. Some of the most important papers from the search results were included. Based on recent studies, some molecules, including those involved in cell-cell and cell-extracellular matrix adhesions, are affected by pomegranate. The other targets of pomegranate are modulators of cytoskeleton dynamics and regulators of cancer cell anoikis and chemotaxis. Furthermore, the antimetastatic effect of pomegranate may be attributed to molecular changes of the extracellular matrix. Pro-inflammatory and pro-angiogenic molecules are the other targets of pomegranate regarding cancer metastasis. A wide variety of molecules can be targeted by pomegranate to suppress tumor metastasis. A better understanding of the molecules regulated by pomegranate is needed to provide a rational basis for its clinical application.http://ijbms.mums.ac.ir/article_13550_a5f09726edfbd03dabedbbf690457a8a.pdfAnoikisCell adhesionChemotaxisCytoskeleton dynamicsExtracellular matrixMetastasisPhytochemicalsPomegranate |
| spellingShingle | Naghmeh Ahmadiankia Molecular targets of pomegranate (Punica granatum) in preventing cancer metastasis Iranian Journal of Basic Medical Sciences Anoikis Cell adhesion Chemotaxis Cytoskeleton dynamics Extracellular matrix Metastasis Phytochemicals Pomegranate |
| title | Molecular targets of pomegranate (Punica granatum) in preventing cancer metastasis |
| title_full | Molecular targets of pomegranate (Punica granatum) in preventing cancer metastasis |
| title_fullStr | Molecular targets of pomegranate (Punica granatum) in preventing cancer metastasis |
| title_full_unstemmed | Molecular targets of pomegranate (Punica granatum) in preventing cancer metastasis |
| title_short | Molecular targets of pomegranate (Punica granatum) in preventing cancer metastasis |
| title_sort | molecular targets of pomegranate punica granatum in preventing cancer metastasis |
| topic | Anoikis Cell adhesion Chemotaxis Cytoskeleton dynamics Extracellular matrix Metastasis Phytochemicals Pomegranate |
| url | http://ijbms.mums.ac.ir/article_13550_a5f09726edfbd03dabedbbf690457a8a.pdf |
| work_keys_str_mv | AT naghmehahmadiankia moleculartargetsofpomegranatepunicagranatuminpreventingcancermetastasis |